https://hypermuscles.com/ Thu, 21 May 2026 17:02:43 +0000 MyBB https://hypermuscles.com/showthread.php?tid=9918 Thu, 12 Jan 2023 13:15:04 +0000 01dragonslayer]]> https://hypermuscles.com/showthread.php?tid=9918
This post is just a simple guide for first time insulin users to follow in a safe, and effective manner.

The type of insulin I’m talking about is Humalog

I urge you to invest in a glucometer. This will give you a close estimation of where your BG(Blood Glucose) levels are (Safe Zone 70-90,but independent upon each individual).You want to take in adequate amounts of carbs, but not too much. As the excess will be stored as fat. And yes, if you aren’t careful, you can add quite a bit of excess body fat. As you’ll see in my dosing example below, we drop carbs slightly as to not to acquire excess BF.

You need to know the signs of hypoglycemia:
The body's biochemical response to hypoglycemia usually starts when sugars are in the high/mid 60's. At this point, the liver releases its stores and the hormones such as glugagon, cortisol, growth hormone and epinephrine, all increase. In many patients, this process occurs without any clinical symptoms.
While there is some degree of variability among people, most will usually develop symptoms suggestive of hypoglycemia when blood glucose levels are lowered to the mid 50's. The first set of symptoms are called neuro-genic (or sympathetic) because they relate to the nervous system's response to hypoglycemia. People may experience any of the following;
• nervousness,
• sweating,
• intense hunger,
• trembling,
• weakness,
• palpitations, and
• often have trouble speaking
To educated yourself further here’s a link http://www.medicinenet.com/hypoglycemia/article.htm

Never go to sleep while slin is active, nor take hot showers, sauna’s, nor tan.


As you already might know. The basic rule is 10g waxy maize to 1 iu of Insulin. Now the trick is to get in tune with your body so to take advantage of the insulin spike, which allows nutrients to be shuttled to the muscle cells rapidly, doing so without taking in excess carbs which equates to body fat.



Below is a 30 day cycle(which is recommended) for Insulin. I don’t use Insulin on off days from the gym. Some like to use Insulin on off days in the morning to fight off the catabolic state we’re in upon awakening. I feel upon awakening in the morning a shake consisting of Whey/ Dextrose would be sufficient, or better yet, SOLID FOOD, to bring you out of this catabolic state from fasting over an 8 hour period while sleeping.


I’ll use the 5 day training split as an example here. That will give you 20 days “on” slin.



Day 1 : 5 iu slin/50g Dextrose

Day 2 : 5 iu slin/50g Dextrose

Day 3 : 5 iu slin/50g Dextrose


Congratulations!! You’ve survived thus far. I assume (hope) you’ve been monitoring your BG levels. You probably have noticed that you are in the higher range using 50g of Dextrose PWO. Now it’s time to drop the carbs slightly. Don’t fret. This should be more than ample amounts (of carbs) to get you through to your PWO meal.



Day 4 : 5 iu slin/40g Dextrose

Day 5 : 5 iu slin/40g Dextrose



At this point you should have a good idea of how you react with Insulin in terms of BG levels vs. carb intake .



Let’s up the dose……



Day 6 : 6 iu slin/50g Dextrose

Day 7 : 6 iu slin/50g Dextrose

By this point in time you should be feeling good( ie; more confident),but still respectful to Insulin. Let’s test the waters for 3 days to give you the feel of things. By that I mean we’ll drop the carb intake slightly so you can find a comfortable ratio in regards to iu’s vs. carbs per gram.



Day 8 : 6 iu slin/40g Dextrose

Day 9 : 6 iu slin/40g Dextrose

Day 10 : 6 iu slin/40g Dextrose


Now, the above ratio’s are safe and effective. You can stop right here and continue on for the next 10 days at the above doses/ratio’s. Or you can move forward slightly.



Day 11 : 7 iu slin/50g Dextrose

Day 12 : 7 iu slin/50g Dextrose

Day 13 : 7 iu slin/50g Dextrose

Day 14 : 7 iu slin/50g Dextrose

Day 15 : & iu slin/50g Dextrose

If you felt confident with the above protocol. You could experiment on days 14-15 and drop your Dextrose to 40g.If you do so, please monitor your BG levels every 15 minutes or so. And have glucose tabs, or another source of quick carbs handy (like orange juice) to stave off any possible signs of hypoglycemia. Don’t panic should this happen, just drink a glass of orange juice, or similar, and in 10 minutes the symptoms will have subsided.



Ok, on to your final week.



Day 16 : 8 iu slin/60g Dextrose

Day 17 : 8 iu slin/60g Dextrose

Day 18 : 8 iu slin/60g Dextrose

Day 19 : 8 iu slin/60g Dextrose

Day 20 : 8 iu slin/60g Dextrose


Congratulations! You just completed your first cycle/experience with Insulin in a safe an effective manner. I stopped at 8 iu’s, Being that is enough to get your feet wet with the drug. You can experiment later on. This was simply a guide.



One last thing. Guys ask “Which way is better?” To take your Whey/ Dextrose in one shake, or Dextrose first, and whey 15 minutes later”?

Bottom line is, it’s just preference. But I do prefer to take my Dextrose first with creatine, BCAA, Luecine, then 15 minutes later have a whey isolate shake.1.5 hrs later have your PWO meal.


~RR]]>
This post is just a simple guide for first time insulin users to follow in a safe, and effective manner.

The type of insulin I’m talking about is Humalog

I urge you to invest in a glucometer. This will give you a close estimation of where your BG(Blood Glucose) levels are (Safe Zone 70-90,but independent upon each individual).You want to take in adequate amounts of carbs, but not too much. As the excess will be stored as fat. And yes, if you aren’t careful, you can add quite a bit of excess body fat. As you’ll see in my dosing example below, we drop carbs slightly as to not to acquire excess BF.

You need to know the signs of hypoglycemia:
The body's biochemical response to hypoglycemia usually starts when sugars are in the high/mid 60's. At this point, the liver releases its stores and the hormones such as glugagon, cortisol, growth hormone and epinephrine, all increase. In many patients, this process occurs without any clinical symptoms.
While there is some degree of variability among people, most will usually develop symptoms suggestive of hypoglycemia when blood glucose levels are lowered to the mid 50's. The first set of symptoms are called neuro-genic (or sympathetic) because they relate to the nervous system's response to hypoglycemia. People may experience any of the following;
• nervousness,
• sweating,
• intense hunger,
• trembling,
• weakness,
• palpitations, and
• often have trouble speaking
To educated yourself further here’s a link http://www.medicinenet.com/hypoglycemia/article.htm

Never go to sleep while slin is active, nor take hot showers, sauna’s, nor tan.


As you already might know. The basic rule is 10g waxy maize to 1 iu of Insulin. Now the trick is to get in tune with your body so to take advantage of the insulin spike, which allows nutrients to be shuttled to the muscle cells rapidly, doing so without taking in excess carbs which equates to body fat.



Below is a 30 day cycle(which is recommended) for Insulin. I don’t use Insulin on off days from the gym. Some like to use Insulin on off days in the morning to fight off the catabolic state we’re in upon awakening. I feel upon awakening in the morning a shake consisting of Whey/ Dextrose would be sufficient, or better yet, SOLID FOOD, to bring you out of this catabolic state from fasting over an 8 hour period while sleeping.


I’ll use the 5 day training split as an example here. That will give you 20 days “on” slin.



Day 1 : 5 iu slin/50g Dextrose

Day 2 : 5 iu slin/50g Dextrose

Day 3 : 5 iu slin/50g Dextrose


Congratulations!! You’ve survived thus far. I assume (hope) you’ve been monitoring your BG levels. You probably have noticed that you are in the higher range using 50g of Dextrose PWO. Now it’s time to drop the carbs slightly. Don’t fret. This should be more than ample amounts (of carbs) to get you through to your PWO meal.



Day 4 : 5 iu slin/40g Dextrose

Day 5 : 5 iu slin/40g Dextrose



At this point you should have a good idea of how you react with Insulin in terms of BG levels vs. carb intake .



Let’s up the dose……



Day 6 : 6 iu slin/50g Dextrose

Day 7 : 6 iu slin/50g Dextrose

By this point in time you should be feeling good( ie; more confident),but still respectful to Insulin. Let’s test the waters for 3 days to give you the feel of things. By that I mean we’ll drop the carb intake slightly so you can find a comfortable ratio in regards to iu’s vs. carbs per gram.



Day 8 : 6 iu slin/40g Dextrose

Day 9 : 6 iu slin/40g Dextrose

Day 10 : 6 iu slin/40g Dextrose


Now, the above ratio’s are safe and effective. You can stop right here and continue on for the next 10 days at the above doses/ratio’s. Or you can move forward slightly.



Day 11 : 7 iu slin/50g Dextrose

Day 12 : 7 iu slin/50g Dextrose

Day 13 : 7 iu slin/50g Dextrose

Day 14 : 7 iu slin/50g Dextrose

Day 15 : & iu slin/50g Dextrose

If you felt confident with the above protocol. You could experiment on days 14-15 and drop your Dextrose to 40g.If you do so, please monitor your BG levels every 15 minutes or so. And have glucose tabs, or another source of quick carbs handy (like orange juice) to stave off any possible signs of hypoglycemia. Don’t panic should this happen, just drink a glass of orange juice, or similar, and in 10 minutes the symptoms will have subsided.



Ok, on to your final week.



Day 16 : 8 iu slin/60g Dextrose

Day 17 : 8 iu slin/60g Dextrose

Day 18 : 8 iu slin/60g Dextrose

Day 19 : 8 iu slin/60g Dextrose

Day 20 : 8 iu slin/60g Dextrose


Congratulations! You just completed your first cycle/experience with Insulin in a safe an effective manner. I stopped at 8 iu’s, Being that is enough to get your feet wet with the drug. You can experiment later on. This was simply a guide.



One last thing. Guys ask “Which way is better?” To take your Whey/ Dextrose in one shake, or Dextrose first, and whey 15 minutes later”?

Bottom line is, it’s just preference. But I do prefer to take my Dextrose first with creatine, BCAA, Luecine, then 15 minutes later have a whey isolate shake.1.5 hrs later have your PWO meal.


~RR]]> https://hypermuscles.com/showthread.php?tid=9912 Wed, 11 Jan 2023 14:57:25 +0000 01dragonslayer]]> https://hypermuscles.com/showthread.php?tid=9912
First off, let me say that if you do not know the process by which to reconstitute a peptide, you should not be playing with HGH. HGH is too expensive to be the first "peptide" you use. I put it in quotes because my research showed HGH does not fall into the definition of being a peptide, yet the reconstitution of it is done by the same method as the other peptides. I will not bore you all with the methodology of how to reconstitute the HGH and instead concentrate on the choice of water alone.

There are basically 5 kinds of water available: BAC Water Benzyl Alcohol (which I will call BAC-BA), BAC Water Sodium Chloride (which I will call BAC-SC), Saline Water, Sterile Water, and Tap Water. I will discuss each of them, below:

Tap Water: If you even consider using tap water at all, you should put down all your needles and never inject yourself again. You WILL get infections from tap water.
Sterile Water: If you plan on injecting all of the HGH shortly after reconstituting it, this should be your primary choice, at least according to Somatropin (which is a HGH manufacturer in Canada).
Saline Water: This water is not much different from Sterile Water other than the addition of salt to make the water the same H as that in your body and to provide some anti-bacterial properties. This should make the shots less painful and last just a little longer. You should treat it the same as Sterile Water for lifespan (use immediately).
BAC-SC: This is the recommended water to use for reconstitution, if you are not going to be using all the reconstituted HGH right way. This water contains sodium chloride 9 mg, benzyl alcohol 0.9%, and hydrochloric acid or sodium hydroxide for pH adjustment. The pH should be 5. This allows the reconstituted water to last up to 28 days in the fridge, or be frozen for a year prior to use.
BAC-BA: This water is NOT recommended as the pH is 5.7, which is slightly to alkaline for the fragile HGH. It does not mean it is guaranteed to destroy your gear, but why risk it?


To recap, if you are going to use all the reconstituted HGH the same day you make it, Sterile Water or Saline Water are both good choices. If you are going to store some HGH for use later, you must use BA-SC (Bacteriostatic Water with 0.9% Sodium Chloride). Do not use Tap Water or BAC-BA (Bacteriostatic Water with 0.9% Benzyl Alcohol).]]>
First off, let me say that if you do not know the process by which to reconstitute a peptide, you should not be playing with HGH. HGH is too expensive to be the first "peptide" you use. I put it in quotes because my research showed HGH does not fall into the definition of being a peptide, yet the reconstitution of it is done by the same method as the other peptides. I will not bore you all with the methodology of how to reconstitute the HGH and instead concentrate on the choice of water alone.

There are basically 5 kinds of water available: BAC Water Benzyl Alcohol (which I will call BAC-BA), BAC Water Sodium Chloride (which I will call BAC-SC), Saline Water, Sterile Water, and Tap Water. I will discuss each of them, below:

Tap Water: If you even consider using tap water at all, you should put down all your needles and never inject yourself again. You WILL get infections from tap water.
Sterile Water: If you plan on injecting all of the HGH shortly after reconstituting it, this should be your primary choice, at least according to Somatropin (which is a HGH manufacturer in Canada).
Saline Water: This water is not much different from Sterile Water other than the addition of salt to make the water the same H as that in your body and to provide some anti-bacterial properties. This should make the shots less painful and last just a little longer. You should treat it the same as Sterile Water for lifespan (use immediately).
BAC-SC: This is the recommended water to use for reconstitution, if you are not going to be using all the reconstituted HGH right way. This water contains sodium chloride 9 mg, benzyl alcohol 0.9%, and hydrochloric acid or sodium hydroxide for pH adjustment. The pH should be 5. This allows the reconstituted water to last up to 28 days in the fridge, or be frozen for a year prior to use.
BAC-BA: This water is NOT recommended as the pH is 5.7, which is slightly to alkaline for the fragile HGH. It does not mean it is guaranteed to destroy your gear, but why risk it?


To recap, if you are going to use all the reconstituted HGH the same day you make it, Sterile Water or Saline Water are both good choices. If you are going to store some HGH for use later, you must use BA-SC (Bacteriostatic Water with 0.9% Sodium Chloride). Do not use Tap Water or BAC-BA (Bacteriostatic Water with 0.9% Benzyl Alcohol).]]> https://hypermuscles.com/showthread.php?tid=9870 Sat, 07 Jan 2023 14:12:25 +0000 01dragonslayer]]> https://hypermuscles.com/showthread.php?tid=9870
Hgh bodybuilder

Bodybuilding With HGH
By Michael Stanford

Bodybuilding with HGH
The Human Growth Hormone (HGH) is produced in the human body, and in several other species as well, by the pituitary gland located at the back side of the brain. Since HGH is responsible in several ways for proper growth by increasing lean muscle mass, lipolysis, strength, and endurance bodybuilding with HGH is a natural consequence.

Falling HGH levels
HGH is one of the few hormones in our body that has tremendous impact on our physical and mental abilities. However, HGH production begins to go into decline starting from somewhere after the 30th year, though technicaly its production peaks at the age of 21. With increasing age the level of HGH keeps falling at the rate of 15% every 10 years.

Synthetic and Natural HGH
Some individuals opt for synthetic HGH in order to make up for this natural deficiency but that is not really the best choice. There are several HGH boosting supplements available that stimulate the body to make more HGH. These supplements are ideal for bodybuilders. Once you start taking HGH boosters you will experience a tremendous boost in muscle mass. Bodybuilding with HGH is also helpful when you wish to gain size quickly.

Normal HGH
In a normal human body the production of new muscle cells stops after puberty. For the rest of your life the quantity of muscle cells is determined by your genetic structure and the only option left for you is to either train to increase the size or to use steroids. HGH is the only for of supplement that can actually grow new muscle cells. This is helpful if the genetic predisposition is towards excessive lack of muscle density. HGH can help you achieve the minimum recommended muscle mass for a human adult.

Benefits of HGH
Another aspect of HGH is that it keeps metabolism and energy levels quite high. Both these factors result in increased ability to burn fat. Bodybuilding with HGH is good because the only weight increase is because of increase lean muscle mass and not fat. HGH also works more gradually. Unlike steroids that result in rapid gains, HGH boosters cause lean muscle mass gain of 2 pounds in 2-3 weeks. Another difference is that steroids mostly cause an increase in water weight whereas HGH causes an increase in lean muscle mass only.]]>
Hgh bodybuilder

Bodybuilding With HGH
By Michael Stanford

Bodybuilding with HGH
The Human Growth Hormone (HGH) is produced in the human body, and in several other species as well, by the pituitary gland located at the back side of the brain. Since HGH is responsible in several ways for proper growth by increasing lean muscle mass, lipolysis, strength, and endurance bodybuilding with HGH is a natural consequence.

Falling HGH levels
HGH is one of the few hormones in our body that has tremendous impact on our physical and mental abilities. However, HGH production begins to go into decline starting from somewhere after the 30th year, though technicaly its production peaks at the age of 21. With increasing age the level of HGH keeps falling at the rate of 15% every 10 years.

Synthetic and Natural HGH
Some individuals opt for synthetic HGH in order to make up for this natural deficiency but that is not really the best choice. There are several HGH boosting supplements available that stimulate the body to make more HGH. These supplements are ideal for bodybuilders. Once you start taking HGH boosters you will experience a tremendous boost in muscle mass. Bodybuilding with HGH is also helpful when you wish to gain size quickly.

Normal HGH
In a normal human body the production of new muscle cells stops after puberty. For the rest of your life the quantity of muscle cells is determined by your genetic structure and the only option left for you is to either train to increase the size or to use steroids. HGH is the only for of supplement that can actually grow new muscle cells. This is helpful if the genetic predisposition is towards excessive lack of muscle density. HGH can help you achieve the minimum recommended muscle mass for a human adult.

Benefits of HGH
Another aspect of HGH is that it keeps metabolism and energy levels quite high. Both these factors result in increased ability to burn fat. Bodybuilding with HGH is good because the only weight increase is because of increase lean muscle mass and not fat. HGH also works more gradually. Unlike steroids that result in rapid gains, HGH boosters cause lean muscle mass gain of 2 pounds in 2-3 weeks. Another difference is that steroids mostly cause an increase in water weight whereas HGH causes an increase in lean muscle mass only.]]> https://hypermuscles.com/showthread.php?tid=9523 Wed, 07 Dec 2022 18:24:14 +0000 01dragonslayer]]> https://hypermuscles.com/showthread.php?tid=9523
Insulin physiology

It is often stated that the primary benefit of insulin in bodybuilding is that it increases the uptake of glucose into muscle and further that this movement of glucose is insulin dependent. But that is not exactly true. It may not be widely known but it is clearly established that insulin is NOT needed for glucose uptake and utilisation in man and therefore glucose uptake is NOT insulin dependent.

There is a sufficient population of glucose transporters in all cell membranes at all times to ensure enough glucose uptake to satisfy the cell’s respiration, even in the absence of insulin. Insulin can and does increase the number of these transporters in some cells but glucose uptake is never truly insulin dependent.

Stimulatory & Inhibiting actions

Through stimulating the translocation or movement of 'Glut 4' glucose transporters from the cytoplasm of muscle and adipose tissue to the cell membrane insulin increases the rate of glucose uptake to values greater than the uptake that takes place in the basal state without insulin.

When insulin is administered to people with diabetes who are fasting, blood glucose concentration falls. It is generally assumed that this is because insulin increases glucose uptake into tissues, particularly muscle. In fact this is NOT the case and is another error arising from extrapolating from in vitro rat data. It has been shown quite unequivocally that insulin at concentrations that are within the normal physiological range lowers blood glucose through inhibiting hepatic glucose production without stimulating peripheral glucose uptake. As hepatic glucose output is 'switched off' by the inhibiting action of insulin, glucose concentration falls and glucose uptake actually decreases. Contrary to most textbooks and previous teaching, glucose uptake is therefore actually increased in uncontrolled diabetes and decreased by insulin administration.

When insulin is given to patients with uncontrolled diabetes it switches off a number of metabolic processes (lipolysis, proteolysis, ketogenesis and gluconeogenesis) by a similar inhibiting action. The result is that free fatty acid (FFA) concentrations fall effectively to zero within minutes and ketogenesis inevitably stops through lack of substrate. It takes a while for the ketones to clear from the circulation, as the 'body load' is massive as they are water and fat soluble and distribute within body water and body fat. Since both ketones and FFA compete with glucose as energy substrate at the point of entry of substrates into the Krebs cycle,glucose metabolism increases inevitably as FFA and ketone levels fall (despite the concomitant fall in plasma glucose concentration).

Thus insulin increases glucose metabolism more through reducing FFA and ketone levels than it does through recruiting more glucose transporters into the muscle cell membrane.

NOTE: The above was taken from:

Mechanism of action of insulin in diabetic patients: a dose-related effect on glucose production and utilisation, Brown P, Tompkins C, Juul S & Sonksen PH, British Medical Journal 1978 1239–1242.

Anabolic effect

Through facilitating glucose entry into cells in amounts greater than needed for cellular respiration insulin will stimulate glycogen formation.

It is possible to increase muscle bulk and performance not only through increasing muscle glycogen stores on a "chronic" basis but also to increase muscle bulk through inhibition of muscle protein breakdown. Just as insulin has an inhibiting action in inhibiting glucose breakdown in muscle glycogen, it also has an equally important inhibiting action in inhibitingprotein breakdown.

The evidence now indicates that insulin does NOT stimulate protein synthesis directly (this process is under the control of growth hormone (GH) and insulin-like growth factor-I (IGF-I)). It has long been known that insulin-treated patients with diabetes have an increase in lean body mass when compared with matched controls. This results from insulin's inhibition ofprotein breakdown in muscle tissue.

Growth Hormone Anabolic Actions

GH’s major action is to stimulate protein synthesis. It is at least as powerful as testosterone in this effect and, as they both operate through distinct pathways, their individual effects are additive or possibly even synergistic. In addition to stimulating protein synthesis, GH simultaneously mobilises fat by a direct lipolytic action. Together, these two effects are responsible for the 'partitioning' action of GH whereby it diverts nutritional calories toprotein synthesis, possibly through using the energy derived from its lipolytic action. It most likely stimulates protein synthesis through mobilisation of amino acid transporters in a manner analogous to insulin and glucose transporters.

IGF-I also acts directly to stimulate protein synthesis but it has a weaker lipolytic action. GH, IGF-I and insulin thus act in concert to stimulate protein synthesis.

GH and IGF-I act in a promoting manner to stimulate protein synthesis while insulin acts in its characteristic inhibiting manner to inhibit protein breakdown. Thus they are synergistic in their powerful anabolic action.

Insulin is essential for the anabolic action of GH. GH administration in the absence of adequate insulin reserves (as during fasting or in Type 1 diabetes) is in fact catabolic and its lipolytic and ketogenic properties can induce diabetic ketoacidosis. Thus GH and insulin are closely linked in normal physiology and it is of great interest to see that athletes have discovered ways in which this normal physiological dependence can be exploited to enhance performance.

NOTE: The above was "lifted" with little change from parts of:

HORMONES AND SPORT: Insulin, growth hormone and sport, P H Sonksen, Journal of Endocrinology (2001) 170, 13–25

Boosting Insulin Naturally
I understand not wanting to use exogenously administered insulin. Does this mean you would lose out on insulin's contribution to GH induced anabolism?

No...you can achieve what would amount to a couple iu of Hum-R by using glucose & leucine. The two work synergistically to spike insulin.

About 3.5 grams of Leucine was sufficient to double the insulin response to 25grams of glucose. See below:

Leucine, when ingested with glucose, synergistically stimulates insulin secretion and lowers blood glucose, Dionysia Kalogeropoulou, Metabolism Clinical and Experimental 57 (2008) 1747–1752

Thereafter, they received 25 g glucose or 1 mmol/kg lean body mass leucine or 1 mmol/kg lean body mass leucine plus 25 g glucose in random order. Serum leucine, glucose, insulin, glucagon, and alpha-amino nitrogen concentrations were measured at various times during a 2.5-hour period after ingestion of the test meal. The amount of leucine provided was equivalent to that present in a high-protein meal, that is, that approximately present in a 350-g steak. After leucine ingestion, the leucine concentration increased 7-fold; and the alpha-amino nitrogen concentration increased by 16%. Ingested leucine did not affect the serum glucose concentration. When leucine was ingested with glucose, it reduced the 2.5-hour glucose area response by 50%. Leucine, when ingested alone, increased the serum insulin area response modestly. However, it increased the insulin area response to glucose by an additional 66%; that is, it almost doubled the response. Ingested leucine stimulated an increase in glucagon. Ingested glucose decreased it. When ingested together, the net effect was essentially no change in glucagon area. In summary, leucine at a dose equivalent to that present in a highprotein meal, had little effect on serum glucose or insulin concentrations but did increase the glucagon concentration. When leucine was ingested with glucose, it attenuated the serum glucose response and strongly stimulated additional insulin secretion. Leucine also attenuated the decrease in glucagon expected when glucose alone is ingested. The data suggest that a rise in glucose concentration is necessary for leucine to stimulate significant insulin secretion. This in turn reduces the glucose response to ingested glucose.]]>
Insulin physiology

It is often stated that the primary benefit of insulin in bodybuilding is that it increases the uptake of glucose into muscle and further that this movement of glucose is insulin dependent. But that is not exactly true. It may not be widely known but it is clearly established that insulin is NOT needed for glucose uptake and utilisation in man and therefore glucose uptake is NOT insulin dependent.

There is a sufficient population of glucose transporters in all cell membranes at all times to ensure enough glucose uptake to satisfy the cell’s respiration, even in the absence of insulin. Insulin can and does increase the number of these transporters in some cells but glucose uptake is never truly insulin dependent.

Stimulatory & Inhibiting actions

Through stimulating the translocation or movement of 'Glut 4' glucose transporters from the cytoplasm of muscle and adipose tissue to the cell membrane insulin increases the rate of glucose uptake to values greater than the uptake that takes place in the basal state without insulin.

When insulin is administered to people with diabetes who are fasting, blood glucose concentration falls. It is generally assumed that this is because insulin increases glucose uptake into tissues, particularly muscle. In fact this is NOT the case and is another error arising from extrapolating from in vitro rat data. It has been shown quite unequivocally that insulin at concentrations that are within the normal physiological range lowers blood glucose through inhibiting hepatic glucose production without stimulating peripheral glucose uptake. As hepatic glucose output is 'switched off' by the inhibiting action of insulin, glucose concentration falls and glucose uptake actually decreases. Contrary to most textbooks and previous teaching, glucose uptake is therefore actually increased in uncontrolled diabetes and decreased by insulin administration.

When insulin is given to patients with uncontrolled diabetes it switches off a number of metabolic processes (lipolysis, proteolysis, ketogenesis and gluconeogenesis) by a similar inhibiting action. The result is that free fatty acid (FFA) concentrations fall effectively to zero within minutes and ketogenesis inevitably stops through lack of substrate. It takes a while for the ketones to clear from the circulation, as the 'body load' is massive as they are water and fat soluble and distribute within body water and body fat. Since both ketones and FFA compete with glucose as energy substrate at the point of entry of substrates into the Krebs cycle,glucose metabolism increases inevitably as FFA and ketone levels fall (despite the concomitant fall in plasma glucose concentration).

Thus insulin increases glucose metabolism more through reducing FFA and ketone levels than it does through recruiting more glucose transporters into the muscle cell membrane.

NOTE: The above was taken from:

Mechanism of action of insulin in diabetic patients: a dose-related effect on glucose production and utilisation, Brown P, Tompkins C, Juul S & Sonksen PH, British Medical Journal 1978 1239–1242.

Anabolic effect

Through facilitating glucose entry into cells in amounts greater than needed for cellular respiration insulin will stimulate glycogen formation.

It is possible to increase muscle bulk and performance not only through increasing muscle glycogen stores on a "chronic" basis but also to increase muscle bulk through inhibition of muscle protein breakdown. Just as insulin has an inhibiting action in inhibiting glucose breakdown in muscle glycogen, it also has an equally important inhibiting action in inhibitingprotein breakdown.

The evidence now indicates that insulin does NOT stimulate protein synthesis directly (this process is under the control of growth hormone (GH) and insulin-like growth factor-I (IGF-I)). It has long been known that insulin-treated patients with diabetes have an increase in lean body mass when compared with matched controls. This results from insulin's inhibition ofprotein breakdown in muscle tissue.

Growth Hormone Anabolic Actions

GH’s major action is to stimulate protein synthesis. It is at least as powerful as testosterone in this effect and, as they both operate through distinct pathways, their individual effects are additive or possibly even synergistic. In addition to stimulating protein synthesis, GH simultaneously mobilises fat by a direct lipolytic action. Together, these two effects are responsible for the 'partitioning' action of GH whereby it diverts nutritional calories toprotein synthesis, possibly through using the energy derived from its lipolytic action. It most likely stimulates protein synthesis through mobilisation of amino acid transporters in a manner analogous to insulin and glucose transporters.

IGF-I also acts directly to stimulate protein synthesis but it has a weaker lipolytic action. GH, IGF-I and insulin thus act in concert to stimulate protein synthesis.

GH and IGF-I act in a promoting manner to stimulate protein synthesis while insulin acts in its characteristic inhibiting manner to inhibit protein breakdown. Thus they are synergistic in their powerful anabolic action.

Insulin is essential for the anabolic action of GH. GH administration in the absence of adequate insulin reserves (as during fasting or in Type 1 diabetes) is in fact catabolic and its lipolytic and ketogenic properties can induce diabetic ketoacidosis. Thus GH and insulin are closely linked in normal physiology and it is of great interest to see that athletes have discovered ways in which this normal physiological dependence can be exploited to enhance performance.

NOTE: The above was "lifted" with little change from parts of:

HORMONES AND SPORT: Insulin, growth hormone and sport, P H Sonksen, Journal of Endocrinology (2001) 170, 13–25

Boosting Insulin Naturally
I understand not wanting to use exogenously administered insulin. Does this mean you would lose out on insulin's contribution to GH induced anabolism?

No...you can achieve what would amount to a couple iu of Hum-R by using glucose & leucine. The two work synergistically to spike insulin.

About 3.5 grams of Leucine was sufficient to double the insulin response to 25grams of glucose. See below:

Leucine, when ingested with glucose, synergistically stimulates insulin secretion and lowers blood glucose, Dionysia Kalogeropoulou, Metabolism Clinical and Experimental 57 (2008) 1747–1752

Thereafter, they received 25 g glucose or 1 mmol/kg lean body mass leucine or 1 mmol/kg lean body mass leucine plus 25 g glucose in random order. Serum leucine, glucose, insulin, glucagon, and alpha-amino nitrogen concentrations were measured at various times during a 2.5-hour period after ingestion of the test meal. The amount of leucine provided was equivalent to that present in a high-protein meal, that is, that approximately present in a 350-g steak. After leucine ingestion, the leucine concentration increased 7-fold; and the alpha-amino nitrogen concentration increased by 16%. Ingested leucine did not affect the serum glucose concentration. When leucine was ingested with glucose, it reduced the 2.5-hour glucose area response by 50%. Leucine, when ingested alone, increased the serum insulin area response modestly. However, it increased the insulin area response to glucose by an additional 66%; that is, it almost doubled the response. Ingested leucine stimulated an increase in glucagon. Ingested glucose decreased it. When ingested together, the net effect was essentially no change in glucagon area. In summary, leucine at a dose equivalent to that present in a highprotein meal, had little effect on serum glucose or insulin concentrations but did increase the glucagon concentration. When leucine was ingested with glucose, it attenuated the serum glucose response and strongly stimulated additional insulin secretion. Leucine also attenuated the decrease in glucagon expected when glucose alone is ingested. The data suggest that a rise in glucose concentration is necessary for leucine to stimulate significant insulin secretion. This in turn reduces the glucose response to ingested glucose.]]> https://hypermuscles.com/showthread.php?tid=9498 Mon, 05 Dec 2022 21:53:37 +0000 01dragonslayer]]> https://hypermuscles.com/showthread.php?tid=9498
Growth Hormone Releasing Hormone (GHRH)- Released by the brain to tell your bodies growth hormone storage cells (somatotrophs) to release growth hormone.

Somatostatin- Acts as the "off switch" and tells your cells (somatotrophs) to cease growth hormone release.

Ghrelin- Created in the stomach, this hunger derived hormone reduces Somatostatins "off switch" effect and encourages the brain to release more GHRH.

If GHRH is always around the somatotrophs (GH storing cells) are constantly releasing and unable to store GH. This results in a constant dribble or "bleed" of GH rather than a big pulse. Growing, development, and maturity requires GH to be released in a pulsatile manner.

This is where Somatostatin comes into play. It instructs your somatotrophs to cease the GH release allowing them to begin storing and stockpiling GH. However if Somatostatin is always present the body would never release enough GH to function. What if GHRH and Somatostatin are trying to work at the same time? For the most part Somatostatin is stronger and no GH will be released.

Further benefiting this hormonal seesaw is Ghrelin. When Ghrelin makes its way up to the brain it makes it easier for GHRH to do it's job by suppressing Somatostatins effects. It is possible for Ghrelin on its own to cause a GH release even with a high Somatostatin presence. However, GHRH and Ghrelin together have a synergistic GH effect, meaning that the spike of GH released is larger than could have been produced by each on their own.

Synthetic forms of Ghrelin exist known as Growth Hormone Releasing Peptides (GHRP's) and act in the same way that natural Ghrelin does.

Growth Hormone Releasing Hormones (GHRH):
CJC-1295

CJC-1293

GRF(1-29)

Sermorelin

Modified GRF(1-29)

Which GHRH?
GRF(1-29) and Sermorelin are essentially the same thing. Sermorelin just being the name of a FDA-approved version of GRF(1-29). The issue here is that these are easily rendered ineffective within minutes of injecting due to destruction by blood enzymes (unless you could pin directly into your pituitary gland). What remains of the list are analogs, or altered versions, of the original GRF(1-29).

Using an anolog that is able to survive blood enzymes for around 30 minutes is ideal

CJC-1293 is GRF(1-29) with 1 amino acid swap plus the Drug Affinity Complex (DAC). DAC acts as a velcro holding the amino acids together for a longer period of time. The single amino acid swap makes the analog peptide stronger but not by enough. The half-life is maybe double GRF(1-29) in humans. So 5 minutes of half-life.

CJC-1295 is GRF(1-29) with 4 amino acid alterations and the Drug Affinity Complex (DAC). This version is extra strong and will last more than 30 minutes and the DAC increases the half-life even more by preventing breakdown by blood enzymes.

Here is the interesting part: You do not want to use any of the CJC's. The first (CJC-1293) does not survive long enough after injection and the second (CJC-1295) survives for too long and is always around preventing Somatostatin from stopping GH release resulting in a GH bleed.

What do you want to use? You want an analog that utilizes those 4 amino acid swaps and mantains the ability to still be broken down after those 30 or so minutes. This is known as Modfied GRF(1-29).

**There is debate as to whether or not CJC-1295 without DAC is the same as Mod GRF(1-29)

Growth Hormone Releasing Peptides, Ghrelin-mimetics (GHRP):
GHRP-6

GHRP-2

Ipamorelin

Hexarelin

Which GHRP?
Hexarelin is the strongest in the family known to give the biggest pulse of all. Will create prolactin and cortisol side effects. Desensitization will happen regardless of the dose.

GHRP-2 has the second strongest GH release, lower hunger effect, and no gastric motility. GHRP-2 will result in the most bang for your buck. This is a second generation GHRP. Usage of this peptide can also come with elevated levels of cortisol and prolactin. Desensitization is unclear if used beyond saturation dose.

GHRP-6 has the second strongest GH release. It can cause an intense hunger effect and gastric motility. This is a first generation GHRP. Slightly creates prolactin and cortisol issues. Desensitization does not occur.

Ipamorelin does not release as much GH as other GHRPs, but at very large doses was shown to give a large release of GH without desensitization. Has no almost no hunger effect. This mildest in the bunch, but does not create prolactin or cortisol.

Dosing Schedules
Injecting a GHRH on its own is not very effective since you are unable to know when your bodies somatostatin is active. Because of this you'll need to pick a GHRP to be paired with your GHRH of choice. This ensures that Somatostatin, if present, will be suppressed and the two peptides will synergistically amplify the natural GH pulse.

Dosing is going to be mostly dependent on your goals and it is generally recommended to asses your tolerance before diving right into multiple doses per day. Starting slow and gradually increasing to multiple doses per day may alleviate some side effects

Note: a saturation dose is defined as 1mcg/kg of bodyweight or 100mcg, the latter being the most commonly used (except in Hexarelin in which 200mcg is considered the saturation dose). Some minority of people have sleep interruption rather than better sleep from pre-bed dosing. Often a move from GHRP-6, GHRP-2, or Hexarelin to the smoother Ipamorelin will remedy this. If not moving the pre-bed dose to the morning often does.

Minimalist- Dosing below saturation levels pre-bed i.e.: ~50mcg each of a GHRP and GHRH

Pre-bed Saturation- 100mcg of each GHRP (except Hexarelin) and GHRH. Results in better overall health, recovery and well being. This is a solid general anti- aging protocol.

Pre-bed & Post Workout Saturation Dose- PWO serves protein metabolism well and increases protein synthesis. Twice a day saturation doses has increased recovery, contribution to anabolism, injury healing, better well being and serious anti-aging properties.

Pre-bed, PWO, and Morning Saturation Doses- The morning dose, when fasted, engages the release of fatty acids which can be burned off for energy during activity. Three saturation doses per day further increases anabolism and decreases catabolism. Local growth factors will rise including systemic IGF-1, but within physiological levels, resulting in no enhanced health dangers, no abnormal organ or structural growth.

There are more advanced dosing protocols but for simplicity they have been left out of this text.

Administration
For best results doses should be administered on an empty stomach (2 or so hours after eating) or with only protein in the stomach. Fats and Carbs blunt the bodies GH release. So, administer your dose, wait 20 minutes for the GH pulse to reach its peak and then you can eat Carbs or fats without having to worry about blunting the GH pulse. If dosing multiple times per day allow at least 3 hours between administrations.]]>
Growth Hormone Releasing Hormone (GHRH)- Released by the brain to tell your bodies growth hormone storage cells (somatotrophs) to release growth hormone.

Somatostatin- Acts as the "off switch" and tells your cells (somatotrophs) to cease growth hormone release.

Ghrelin- Created in the stomach, this hunger derived hormone reduces Somatostatins "off switch" effect and encourages the brain to release more GHRH.

If GHRH is always around the somatotrophs (GH storing cells) are constantly releasing and unable to store GH. This results in a constant dribble or "bleed" of GH rather than a big pulse. Growing, development, and maturity requires GH to be released in a pulsatile manner.

This is where Somatostatin comes into play. It instructs your somatotrophs to cease the GH release allowing them to begin storing and stockpiling GH. However if Somatostatin is always present the body would never release enough GH to function. What if GHRH and Somatostatin are trying to work at the same time? For the most part Somatostatin is stronger and no GH will be released.

Further benefiting this hormonal seesaw is Ghrelin. When Ghrelin makes its way up to the brain it makes it easier for GHRH to do it's job by suppressing Somatostatins effects. It is possible for Ghrelin on its own to cause a GH release even with a high Somatostatin presence. However, GHRH and Ghrelin together have a synergistic GH effect, meaning that the spike of GH released is larger than could have been produced by each on their own.

Synthetic forms of Ghrelin exist known as Growth Hormone Releasing Peptides (GHRP's) and act in the same way that natural Ghrelin does.

Growth Hormone Releasing Hormones (GHRH):
CJC-1295

CJC-1293

GRF(1-29)

Sermorelin

Modified GRF(1-29)

Which GHRH?
GRF(1-29) and Sermorelin are essentially the same thing. Sermorelin just being the name of a FDA-approved version of GRF(1-29). The issue here is that these are easily rendered ineffective within minutes of injecting due to destruction by blood enzymes (unless you could pin directly into your pituitary gland). What remains of the list are analogs, or altered versions, of the original GRF(1-29).

Using an anolog that is able to survive blood enzymes for around 30 minutes is ideal

CJC-1293 is GRF(1-29) with 1 amino acid swap plus the Drug Affinity Complex (DAC). DAC acts as a velcro holding the amino acids together for a longer period of time. The single amino acid swap makes the analog peptide stronger but not by enough. The half-life is maybe double GRF(1-29) in humans. So 5 minutes of half-life.

CJC-1295 is GRF(1-29) with 4 amino acid alterations and the Drug Affinity Complex (DAC). This version is extra strong and will last more than 30 minutes and the DAC increases the half-life even more by preventing breakdown by blood enzymes.

Here is the interesting part: You do not want to use any of the CJC's. The first (CJC-1293) does not survive long enough after injection and the second (CJC-1295) survives for too long and is always around preventing Somatostatin from stopping GH release resulting in a GH bleed.

What do you want to use? You want an analog that utilizes those 4 amino acid swaps and mantains the ability to still be broken down after those 30 or so minutes. This is known as Modfied GRF(1-29).

**There is debate as to whether or not CJC-1295 without DAC is the same as Mod GRF(1-29)

Growth Hormone Releasing Peptides, Ghrelin-mimetics (GHRP):
GHRP-6

GHRP-2

Ipamorelin

Hexarelin

Which GHRP?
Hexarelin is the strongest in the family known to give the biggest pulse of all. Will create prolactin and cortisol side effects. Desensitization will happen regardless of the dose.

GHRP-2 has the second strongest GH release, lower hunger effect, and no gastric motility. GHRP-2 will result in the most bang for your buck. This is a second generation GHRP. Usage of this peptide can also come with elevated levels of cortisol and prolactin. Desensitization is unclear if used beyond saturation dose.

GHRP-6 has the second strongest GH release. It can cause an intense hunger effect and gastric motility. This is a first generation GHRP. Slightly creates prolactin and cortisol issues. Desensitization does not occur.

Ipamorelin does not release as much GH as other GHRPs, but at very large doses was shown to give a large release of GH without desensitization. Has no almost no hunger effect. This mildest in the bunch, but does not create prolactin or cortisol.

Dosing Schedules
Injecting a GHRH on its own is not very effective since you are unable to know when your bodies somatostatin is active. Because of this you'll need to pick a GHRP to be paired with your GHRH of choice. This ensures that Somatostatin, if present, will be suppressed and the two peptides will synergistically amplify the natural GH pulse.

Dosing is going to be mostly dependent on your goals and it is generally recommended to asses your tolerance before diving right into multiple doses per day. Starting slow and gradually increasing to multiple doses per day may alleviate some side effects

Note: a saturation dose is defined as 1mcg/kg of bodyweight or 100mcg, the latter being the most commonly used (except in Hexarelin in which 200mcg is considered the saturation dose). Some minority of people have sleep interruption rather than better sleep from pre-bed dosing. Often a move from GHRP-6, GHRP-2, or Hexarelin to the smoother Ipamorelin will remedy this. If not moving the pre-bed dose to the morning often does.

Minimalist- Dosing below saturation levels pre-bed i.e.: ~50mcg each of a GHRP and GHRH

Pre-bed Saturation- 100mcg of each GHRP (except Hexarelin) and GHRH. Results in better overall health, recovery and well being. This is a solid general anti- aging protocol.

Pre-bed & Post Workout Saturation Dose- PWO serves protein metabolism well and increases protein synthesis. Twice a day saturation doses has increased recovery, contribution to anabolism, injury healing, better well being and serious anti-aging properties.

Pre-bed, PWO, and Morning Saturation Doses- The morning dose, when fasted, engages the release of fatty acids which can be burned off for energy during activity. Three saturation doses per day further increases anabolism and decreases catabolism. Local growth factors will rise including systemic IGF-1, but within physiological levels, resulting in no enhanced health dangers, no abnormal organ or structural growth.

There are more advanced dosing protocols but for simplicity they have been left out of this text.

Administration
For best results doses should be administered on an empty stomach (2 or so hours after eating) or with only protein in the stomach. Fats and Carbs blunt the bodies GH release. So, administer your dose, wait 20 minutes for the GH pulse to reach its peak and then you can eat Carbs or fats without having to worry about blunting the GH pulse. If dosing multiple times per day allow at least 3 hours between administrations.]]> https://hypermuscles.com/showthread.php?tid=9425 Sat, 26 Nov 2022 14:13:27 +0000 01dragonslayer]]> https://hypermuscles.com/showthread.php?tid=9425 Active Life: Varies by injection method

Human Growth Hormone is a proteinaceous hormone made up of a chain of 191 amino acids and is produced by the pituitary gland. It is responsible for the protein deposition, growth of tissues, and the breakdown of subcutaneous fat stores. Human growth hormone is produced in its highest levels during adolescence, as should be no surprise since this is when the majority of a person's body growth occurs. In adulthood, growth hormone still circulates in the body but at much lower levels. The primary medical purpose for administration of human growth hormone is for those that suffer from a deficiency of the hormone during their adolescence so that normal growth can occur. However in recent years the popularity of human growth hormone has surged as a means to treat age-related degenerative conditions, as well as other so-called "anti-aging" therapies.

Human growth hormone first became available in the 1980's. At first it was extracted from the pituitary glands of cadavers. This practice was discontinued however when it was determined that administration of the hormone that was collected this way was linked to the spread of a fatal brain disease. All of the human growth hormone that is now produced is synthetic.

In terms of the use of human growth hormone for strength athletes and bodybuilders, the effects are two fold. First, it has been demonstrated that consistent administration of human growth hormone can help to promote loss of body fat. In part this is due to the ability of the compound to cause cells in the body to increase the rate with which they utilize fats while also decreasing the rate that carbohydrates are used. This fat loss is achieved because of the ability of growth hormone to stimulate triglyceride hydrolysis in adipose tissue as well2 .

In conjunction with this, human growth hormone helps to promote the movement of amino acids through cell membranes. This, along with the fact that growth hormone promotes the growth of the cells in the body and increases the rate at which these cells divide and multiple, obviously indicates that it is also capable of enhancing anabolism if used at appropriate doses.

Many users also have an interest in using human growth hormone for the ability of the compound to help heal existing injuries and prevent new ones from occurring. There is some evidence that growth hormone can help to promote the production of new and regeneration of damaged cartilage when used in conjunction with insulin-like growth factor. It is actually the insulin-like growth factor that stimulates the production of cartilage. Insulin-like growth factor is released from the liver in response to circulating growth hormone3 .

It has also been demonstrated that human growth hormone has positive effects on erythropoeisis, i.e. the manufacture of red blood cells4 . This effect should help to improve the endurance of an athlete and may also help to promote anabolism. To the degree with which this effect will occur in users varies quite widely, but all users should show some improvement.

Use/Dosing
Human growth hormone is primarily secreted in rhythmic pulses during sleep. This occurs by the mechanism of Growth Hormone Releasing Hormone and Somatostatin being released in an alternating fashion. For the most part users will want to mimic the natural release of growth hormone, while also not disrupting the body's natural production of the hormone. This is often a delicate balance.

Dosing Schedule
In terms of a dosing schedule for the compound, there is some controversy as to the best method for fat loss/anabolism. It is thought by many that daily dosing is of primary importance when using human growth hormone due to the extremely short active life of the drug. Blood concentrations of the hormone reach their peak within two to six hours of the injection, with the half life being only twenty to thirty minutes3 . This of course makes it impossible to maintain stable blood levels of the compound.

However a stable level of the hormone is seemingly unnecessary as this does not occur naturally when the body produces the hormone. In fact there is some research that indicates that administration of the hormone every other day, instead of injections every day, may result in a more efficient use of the hormone. In a study using children ranging in ages of two to four, it was demonstrated that administration of the compound every other day, as opposed to every day, resulted in more growth in the children giving this dosing schedule5 . One theory as to why this may occur is that injections every other day may simulate the natural pulsile frequency of growth hormone secretion. This would also allow the growth hormone receptors in the body recover from the surge of growth hormone that would be circulating and then be better able to make use of the next dose that is administered the next day.

The only problem with the above theory is that it has never been tested in terms of its effect on muscle growth and/or fat loss, only in the height growth in extremely young children. For the most part strength athletes and bodybuilders have administered growth hormone every day and have achieved good results. This method would seemingly provide a user with a consistent wave of growth hormone throughout their cycle and allow the body to utilize it rather efficiently.

Another common practice among users is to run growth hormone for five days and then take one or two days off, or some other similar schedule. This would seemingly be "splitting the difference" between the two dosing schedules outlined above (as well as save money), but there is no research to indicate that it is of any significant benefit either way.

As for the time of day a user should inject human growth hormone, it would be least disruptive to the natural release of the hormone to administer it sometime early in the day. If a user were to inject it close to when they were going to sleep, this would surely negate any natural release of growth hormone, something that a user would obviously want to avoid. There is no standard to which most adhere to when deciding how close to going to sleep that they will administer growth hormone, however mid-afternoon should be early enough that it does not interfere with the natural release of the hormone during sleep.

Dosages
In terms of dosages needed to see specific results, there is primarily only anecdotal evidence to be relied upon when it comes to fat loss and an anabolic response. The relevant research does not discuss these effects in any great scope. However, most users have indicated that doses of approximately two to four international units (2-4 iu) per day in men will usually produce a noticeable loss of body fat in most users. In terms of getting an anabolic response, the experience of users vary considerably. For the most part it can be concluded that most users will need to administer larger doses than needed to experience fat loss if they wish to see a noticeable anabolic response from human growth hormone. How much more varies from individual to individual. There are some users who have indicated that using extremely large doses of the hormone has resulted in dramatic gains in muscle mass, but often these doses are cost prohibitive for most. Individuals will likely have to experiment themselves to find a level that they are comfortable with, as well as what they can afford.]]> Active Life: Varies by injection method

Human Growth Hormone is a proteinaceous hormone made up of a chain of 191 amino acids and is produced by the pituitary gland. It is responsible for the protein deposition, growth of tissues, and the breakdown of subcutaneous fat stores. Human growth hormone is produced in its highest levels during adolescence, as should be no surprise since this is when the majority of a person's body growth occurs. In adulthood, growth hormone still circulates in the body but at much lower levels. The primary medical purpose for administration of human growth hormone is for those that suffer from a deficiency of the hormone during their adolescence so that normal growth can occur. However in recent years the popularity of human growth hormone has surged as a means to treat age-related degenerative conditions, as well as other so-called "anti-aging" therapies.

Human growth hormone first became available in the 1980's. At first it was extracted from the pituitary glands of cadavers. This practice was discontinued however when it was determined that administration of the hormone that was collected this way was linked to the spread of a fatal brain disease. All of the human growth hormone that is now produced is synthetic.

In terms of the use of human growth hormone for strength athletes and bodybuilders, the effects are two fold. First, it has been demonstrated that consistent administration of human growth hormone can help to promote loss of body fat. In part this is due to the ability of the compound to cause cells in the body to increase the rate with which they utilize fats while also decreasing the rate that carbohydrates are used. This fat loss is achieved because of the ability of growth hormone to stimulate triglyceride hydrolysis in adipose tissue as well2 .

In conjunction with this, human growth hormone helps to promote the movement of amino acids through cell membranes. This, along with the fact that growth hormone promotes the growth of the cells in the body and increases the rate at which these cells divide and multiple, obviously indicates that it is also capable of enhancing anabolism if used at appropriate doses.

Many users also have an interest in using human growth hormone for the ability of the compound to help heal existing injuries and prevent new ones from occurring. There is some evidence that growth hormone can help to promote the production of new and regeneration of damaged cartilage when used in conjunction with insulin-like growth factor. It is actually the insulin-like growth factor that stimulates the production of cartilage. Insulin-like growth factor is released from the liver in response to circulating growth hormone3 .

It has also been demonstrated that human growth hormone has positive effects on erythropoeisis, i.e. the manufacture of red blood cells4 . This effect should help to improve the endurance of an athlete and may also help to promote anabolism. To the degree with which this effect will occur in users varies quite widely, but all users should show some improvement.

Use/Dosing
Human growth hormone is primarily secreted in rhythmic pulses during sleep. This occurs by the mechanism of Growth Hormone Releasing Hormone and Somatostatin being released in an alternating fashion. For the most part users will want to mimic the natural release of growth hormone, while also not disrupting the body's natural production of the hormone. This is often a delicate balance.

Dosing Schedule
In terms of a dosing schedule for the compound, there is some controversy as to the best method for fat loss/anabolism. It is thought by many that daily dosing is of primary importance when using human growth hormone due to the extremely short active life of the drug. Blood concentrations of the hormone reach their peak within two to six hours of the injection, with the half life being only twenty to thirty minutes3 . This of course makes it impossible to maintain stable blood levels of the compound.

However a stable level of the hormone is seemingly unnecessary as this does not occur naturally when the body produces the hormone. In fact there is some research that indicates that administration of the hormone every other day, instead of injections every day, may result in a more efficient use of the hormone. In a study using children ranging in ages of two to four, it was demonstrated that administration of the compound every other day, as opposed to every day, resulted in more growth in the children giving this dosing schedule5 . One theory as to why this may occur is that injections every other day may simulate the natural pulsile frequency of growth hormone secretion. This would also allow the growth hormone receptors in the body recover from the surge of growth hormone that would be circulating and then be better able to make use of the next dose that is administered the next day.

The only problem with the above theory is that it has never been tested in terms of its effect on muscle growth and/or fat loss, only in the height growth in extremely young children. For the most part strength athletes and bodybuilders have administered growth hormone every day and have achieved good results. This method would seemingly provide a user with a consistent wave of growth hormone throughout their cycle and allow the body to utilize it rather efficiently.

Another common practice among users is to run growth hormone for five days and then take one or two days off, or some other similar schedule. This would seemingly be "splitting the difference" between the two dosing schedules outlined above (as well as save money), but there is no research to indicate that it is of any significant benefit either way.

As for the time of day a user should inject human growth hormone, it would be least disruptive to the natural release of the hormone to administer it sometime early in the day. If a user were to inject it close to when they were going to sleep, this would surely negate any natural release of growth hormone, something that a user would obviously want to avoid. There is no standard to which most adhere to when deciding how close to going to sleep that they will administer growth hormone, however mid-afternoon should be early enough that it does not interfere with the natural release of the hormone during sleep.

Dosages
In terms of dosages needed to see specific results, there is primarily only anecdotal evidence to be relied upon when it comes to fat loss and an anabolic response. The relevant research does not discuss these effects in any great scope. However, most users have indicated that doses of approximately two to four international units (2-4 iu) per day in men will usually produce a noticeable loss of body fat in most users. In terms of getting an anabolic response, the experience of users vary considerably. For the most part it can be concluded that most users will need to administer larger doses than needed to experience fat loss if they wish to see a noticeable anabolic response from human growth hormone. How much more varies from individual to individual. There are some users who have indicated that using extremely large doses of the hormone has resulted in dramatic gains in muscle mass, but often these doses are cost prohibitive for most. Individuals will likely have to experiment themselves to find a level that they are comfortable with, as well as what they can afford.]]> https://hypermuscles.com/showthread.php?tid=9242 Sun, 18 Oct 2020 03:16:51 +0000 BidoBandito]]> https://hypermuscles.com/showthread.php?tid=9242 https://hypermuscles.com/showthread.php?tid=8997 Sat, 30 Nov 2019 14:55:53 +0000 dfwtp]]> https://hypermuscles.com/showthread.php?tid=8997
some say it doesnt matter how why, just get it in
others say, details matter
some say use with insulin?

what everyone say]]>
some say it doesnt matter how why, just get it in
others say, details matter
some say use with insulin?

what everyone say]]> https://hypermuscles.com/showthread.php?tid=8918 Mon, 09 Sep 2019 14:45:00 +0000 dreambig]]> https://hypermuscles.com/showthread.php?tid=8918 https://hypermuscles.com/showthread.php?tid=8914 Thu, 05 Sep 2019 01:41:41 +0000 tj805]]> https://hypermuscles.com/showthread.php?tid=8914 guidelines that I acquired from another forum. I found these to be extremely informative and beneficial. I can not take credit for any of the research associated with these profiles. Therefore, I must stress the importance of doing your own research. These protocols and guidelines are strictly for educational purposes. I do not condone the use of illicit substances, nor am I qualified physician to give medical advice. Use at your own risk!]]> guidelines that I acquired from another forum. I found these to be extremely informative and beneficial. I can not take credit for any of the research associated with these profiles. Therefore, I must stress the importance of doing your own research. These protocols and guidelines are strictly for educational purposes. I do not condone the use of illicit substances, nor am I qualified physician to give medical advice. Use at your own risk!]]> https://hypermuscles.com/showthread.php?tid=8794 Fri, 15 Mar 2019 10:38:26 +0000 admin1]]> https://hypermuscles.com/showthread.php?tid=8794 This is not mine article but was taken from web.


HGH mixing (reconstitution) instruction:

Remove the plastic cap from the top of the vial and clean the rubber with a medical alcohol pad/swab. Take and insulin syringe and pull 1 ml of water (100 markings) into it. Note: regardless of how much water you use (be it 1ml or 2ml) the mixture still has the same overall strength. Water is just a transport method for the HGH. If you used double amount of water when reconstituting the HGH, you would have to use double amount of mixture when injecting yourself to get the same dose. People usually use 1ml because it fits fully into a standard insulin type syringe.


You now have 1ml of water in the syringe. Push the needle through the rubber cap of the vial, but position it sideways so that the water will slide down the inside wall of the vial. Do not inject directly into the powder with force, rather let the water slide out slowly.


Majority of the white powder will dissolve within seconds, but there will be some lumps left over. Do not shake the vial in an attempt to get them to dissolve. If you are in a hurry, you can gently roll the vial between your fingers. If you do this for a few minutes all of the powder will dissolve. Alternatively you can let the vial sit in the refrigerator for 15 - 30 minutes. By that time the somatropin will dissolve completely.


Before pulling the liquid HGH into the insulin syringe, give the vial a few turns between your fingers to gently mix the solution. The HGH vials are under vacuum (negative air pressure) which makes it harder to pull the liquid out. To relieve the vacuum inject a full syringe of air into the top of the vial (do not make the liquid bubble).


Some people use a new syringe for each injection, others pull the entire content of the HGH vial into the syringe and reuse it several times until it's empty. The choice is yours.]]> This is not mine article but was taken from web.


HGH mixing (reconstitution) instruction:

Remove the plastic cap from the top of the vial and clean the rubber with a medical alcohol pad/swab. Take and insulin syringe and pull 1 ml of water (100 markings) into it. Note: regardless of how much water you use (be it 1ml or 2ml) the mixture still has the same overall strength. Water is just a transport method for the HGH. If you used double amount of water when reconstituting the HGH, you would have to use double amount of mixture when injecting yourself to get the same dose. People usually use 1ml because it fits fully into a standard insulin type syringe.


You now have 1ml of water in the syringe. Push the needle through the rubber cap of the vial, but position it sideways so that the water will slide down the inside wall of the vial. Do not inject directly into the powder with force, rather let the water slide out slowly.


Majority of the white powder will dissolve within seconds, but there will be some lumps left over. Do not shake the vial in an attempt to get them to dissolve. If you are in a hurry, you can gently roll the vial between your fingers. If you do this for a few minutes all of the powder will dissolve. Alternatively you can let the vial sit in the refrigerator for 15 - 30 minutes. By that time the somatropin will dissolve completely.


Before pulling the liquid HGH into the insulin syringe, give the vial a few turns between your fingers to gently mix the solution. The HGH vials are under vacuum (negative air pressure) which makes it harder to pull the liquid out. To relieve the vacuum inject a full syringe of air into the top of the vial (do not make the liquid bubble).


Some people use a new syringe for each injection, others pull the entire content of the HGH vial into the syringe and reuse it several times until it's empty. The choice is yours.]]> https://hypermuscles.com/showthread.php?tid=8779 Mon, 25 Feb 2019 01:31:09 +0000 01dragonslayer]]> https://hypermuscles.com/showthread.php?tid=8779
HGH may not provide quick satisfaction, but there's a reason why many people use this compound: it works!

HGH provides a number of positive changes in your health and overall life. Of course, you'll no doubt be curious as to when these changes will occur. Here's a look at when you'll begin seeing noticeable results with each benefit.

Fat Loss
Human growth hormone is one of the most-powerful drugs you can use with regard to fat loss. A 1990 study appearing in the New England Journal of Medicine shows that participants lost 14% body fat and gained 8.8% lean muscle after using HGH for several months.

Additional research presented at the 1999 Endocrine Society conference shows that patients lost 13% body fat and gained 4% lean muscle through HGH. This same study also revealed that human growth hormone burns over twice as much fat as taking testosterone!

You should see noticeable fat-loss results from this drug in as little as a few weeks. But studies show that it'll take you a few months before experiencing HGH's dramatic fat-burning effects.

Muscle Gain
HGH doesn't have the incredible anabolic properties of steroids. But it does help you gain significant muscle through indirect means, such as faster workout recovery and increased IGF-1 production.

You should begin noticing a change in your muscle composition by the second month of use. These changes will appear more-pronounced as you burn fat with HGH too.

Healing Injuries
One of this drug's best use cases is speeding up injury recovery. A 2010 Danish study revealed that HGH can heal damaged ligaments and tendons at a six-fold rate, thanks to increased collagen synthesis. This compound can also cause rapid recovery from bone fractures and lower back injuries.

Healing from injuries can take time, so it's difficult to put an exact timetable on when you'll experience this benefit. But clearly, HGH will help you get back to full speed much quicker than letting injuries heal naturally.

More Energy
Many human growth hormone users feel a surge of energy and stamina while they're on the drug. On average, you should begin feeling more energetic after just 1-2 weeks of HGH usage.

This high-energy state will become enhanced as you experience other HGH benefits, such as fat loss, more muscle mass, better sleep quality, and faster workout recovery.

Improved Skin
HGH is well touted for its anti-aging benefits. And while you won't suddenly look 20 years younger just because you're on human growth hormone, you can expect a better appearance over time.

Human growth hormone works to regenerate your skin cells, thus restoring your skin's thickness and firmness. In turn, this staves off wrinkles and sagging skin.

You should experience firmer skin after 2-3 months of use, along with reductions in cellulite and other aging signs after 4-6 months.

Better Sleep Quality
An adequate HGH level helps you fall asleep faster and get more restful sleep. This is a cycle, because deep sleep allows your body to produce more natural growth hormone.

If you're having trouble getting rest, then using HGH helps you attain better sleep quality. You'll experience this benefit after just a few weeks of using the drug.

Enhanced Mood
Low growth hormone contributes to wild mood swings and poor cognitive function. HGH remedies this problem by bringing your growth hormone level back into balance and helping you maintain a positive mood.

Research shows that 18 patients who took HGH for just six weeks improved their mood and cognitive function considerably. Therefore, you should experience this benefit in several weeks' time.

Is It Worth Waiting for HGH Benefits?
The HGH advantages that I've covered here can take anywhere from a few weeks to several months to kick in. Much of how quickly you receive the benefits depends upon your dosage size.

But even with higher doses, you shouldn’t expect HGH's perks to happen overnight. That said, you may wonder if it's worth waiting for the results.

The answer is yes, it is worth waiting. This is especially true when considering that HGH can do things for your body that don't occur naturally — at least not within any reasonable time frame.

Your body produces less natural growth hormone as you age. This makes it harder to burn fat, build muscle, sleep, heal injuries, and maintain a good mood. But using synthetic growth hormone helps you maintain a healthy lifestyle and excel in your pursuits, even as you get older.

HGH also offers tremendous athletic benefits over time, including more IGF-1 production (leading to more muscle), faster workout recovery, and accelerated fat burning.

Of course, patience is the key when using human growth hormone. As long as you can wait for the benefits, then you'll truly appreciate what this drug has to offer.]]>
HGH may not provide quick satisfaction, but there's a reason why many people use this compound: it works!

HGH provides a number of positive changes in your health and overall life. Of course, you'll no doubt be curious as to when these changes will occur. Here's a look at when you'll begin seeing noticeable results with each benefit.

Fat Loss
Human growth hormone is one of the most-powerful drugs you can use with regard to fat loss. A 1990 study appearing in the New England Journal of Medicine shows that participants lost 14% body fat and gained 8.8% lean muscle after using HGH for several months.

Additional research presented at the 1999 Endocrine Society conference shows that patients lost 13% body fat and gained 4% lean muscle through HGH. This same study also revealed that human growth hormone burns over twice as much fat as taking testosterone!

You should see noticeable fat-loss results from this drug in as little as a few weeks. But studies show that it'll take you a few months before experiencing HGH's dramatic fat-burning effects.

Muscle Gain
HGH doesn't have the incredible anabolic properties of steroids. But it does help you gain significant muscle through indirect means, such as faster workout recovery and increased IGF-1 production.

You should begin noticing a change in your muscle composition by the second month of use. These changes will appear more-pronounced as you burn fat with HGH too.

Healing Injuries
One of this drug's best use cases is speeding up injury recovery. A 2010 Danish study revealed that HGH can heal damaged ligaments and tendons at a six-fold rate, thanks to increased collagen synthesis. This compound can also cause rapid recovery from bone fractures and lower back injuries.

Healing from injuries can take time, so it's difficult to put an exact timetable on when you'll experience this benefit. But clearly, HGH will help you get back to full speed much quicker than letting injuries heal naturally.

More Energy
Many human growth hormone users feel a surge of energy and stamina while they're on the drug. On average, you should begin feeling more energetic after just 1-2 weeks of HGH usage.

This high-energy state will become enhanced as you experience other HGH benefits, such as fat loss, more muscle mass, better sleep quality, and faster workout recovery.

Improved Skin
HGH is well touted for its anti-aging benefits. And while you won't suddenly look 20 years younger just because you're on human growth hormone, you can expect a better appearance over time.

Human growth hormone works to regenerate your skin cells, thus restoring your skin's thickness and firmness. In turn, this staves off wrinkles and sagging skin.

You should experience firmer skin after 2-3 months of use, along with reductions in cellulite and other aging signs after 4-6 months.

Better Sleep Quality
An adequate HGH level helps you fall asleep faster and get more restful sleep. This is a cycle, because deep sleep allows your body to produce more natural growth hormone.

If you're having trouble getting rest, then using HGH helps you attain better sleep quality. You'll experience this benefit after just a few weeks of using the drug.

Enhanced Mood
Low growth hormone contributes to wild mood swings and poor cognitive function. HGH remedies this problem by bringing your growth hormone level back into balance and helping you maintain a positive mood.

Research shows that 18 patients who took HGH for just six weeks improved their mood and cognitive function considerably. Therefore, you should experience this benefit in several weeks' time.

Is It Worth Waiting for HGH Benefits?
The HGH advantages that I've covered here can take anywhere from a few weeks to several months to kick in. Much of how quickly you receive the benefits depends upon your dosage size.

But even with higher doses, you shouldn’t expect HGH's perks to happen overnight. That said, you may wonder if it's worth waiting for the results.

The answer is yes, it is worth waiting. This is especially true when considering that HGH can do things for your body that don't occur naturally — at least not within any reasonable time frame.

Your body produces less natural growth hormone as you age. This makes it harder to burn fat, build muscle, sleep, heal injuries, and maintain a good mood. But using synthetic growth hormone helps you maintain a healthy lifestyle and excel in your pursuits, even as you get older.

HGH also offers tremendous athletic benefits over time, including more IGF-1 production (leading to more muscle), faster workout recovery, and accelerated fat burning.

Of course, patience is the key when using human growth hormone. As long as you can wait for the benefits, then you'll truly appreciate what this drug has to offer.]]> https://hypermuscles.com/showthread.php?tid=8622 Wed, 19 Dec 2018 08:35:17 +0000 Huge Tom]]> https://hypermuscles.com/showthread.php?tid=8622 https://hypermuscles.com/showthread.php?tid=8592 Mon, 17 Dec 2018 18:41:58 +0000 01dragonslayer]]> https://hypermuscles.com/showthread.php?tid=8592 https://johndoebodybuilding.com/insulin/]]> https://johndoebodybuilding.com/insulin/]]> https://hypermuscles.com/showthread.php?tid=8582 Sat, 15 Dec 2018 11:58:10 +0000 01dragonslayer]]> https://hypermuscles.com/showthread.php?tid=8582 https://johndoebodybuilding.com/20-week-...lin-blast/]]> https://johndoebodybuilding.com/20-week-...lin-blast/]]>