https://hypermuscles.com/ Thu, 21 May 2026 17:02:43 +0000 MyBB https://hypermuscles.com/showthread.php?tid=5265 Thu, 03 Jul 2014 03:54:39 +0000 weyes]]> https://hypermuscles.com/showthread.php?tid=5265 https://hypermuscles.com/showthread.php?tid=5125 Sun, 15 Jun 2014 04:06:28 +0000 Cornish_Celt]]> https://hypermuscles.com/showthread.php?tid=5125 DNP (2,4-Dinitrophenol)

DNP (2,4-Dinitrophenol), an industrial chemical with various applications, has gained steady popularity as a fat loss tool. Boasting an astounding 50% increase in metabolic rate, it is able to contribute to reported fat losses of 10-12 pounds in 8 days of use. Classified as an “uncoupler of oxidative phosphorylation” medically, it is quite dangerous as there is no negative feedback system that may deal with overdoses. Specifically, there is no upper limit to the increase in body temperature that may be obtained with its use.

Introduction/History

Competitive bodybuilders and many others are continually on a quest for leanness. Used by the hardcore since Dan Duchaine’s reporting of it a couple years ago, DNP (2,4-Dinitrophenol) has managed to steadily gain popularity as a powerful tool for weight loss. Interestingly, DNP was first used to ignite TNT in the early 1900’s. In 1931 a study released by Stanford University declared that DNP was able to cause amazing weight loss; subsequently it found its way into many diet potions and medications; regulation was much less strict during this time than the present, and many of these products were available over the counter. Two years later DNP was banned by the FDA as a dieting agent due to its inclusion in many OTC dietary supplements. The FDA was a new organization at this time and acted in a rather brazen manner, with the absence of any set procedures for taking substances off the market. Granted, there was only a 1% incidence of cataracts over a large population (around 100,000); nonetheless it happened (although interestingly, exclusively women). However, there are now ways to counter this which will be covered thoroughly.

The comparisons to the current drugs used for dieting are astounding, at least in terms of thermogenesis. While the ECA stack has been shown to provide approximately a 3% increase in metabolic rate, DNP can deliver a relatively controlled 50% elevation in resting metabolic rate. The thermogenic aspect of clenbuterol, while sometimes overestimated due to the high CNS stimulation that yields a “wired” feeling, can vary according to prior exposure to various amphetamine-like compounds and certainly is not much greater than that of ECA. DNP does not have the anorectic effects of ephedrine or other thermogenic agents; rather, it tends to increase hunger, particularly appetite for carbohydrates. This problem is easily solved with appetite suppressants, and one may even use ECA itself for this purpose while on DNP.

Molecular Basis for Efficacy

DNP accomplishes the astounding boost in metabolic rate via inhibition of the F0F1 ATP synthase molecule, located in the inner wall of each mitochondrion. While the electron transport chain still functions to pump hydrogen ions into the intermembrane space, the coupling of the proton gradient to ATP production is rendered impossible by DNP. As a result, ATP production is dramatically reduced, and the energy is instead thrown off as heat. This results in an astounding production of heat; when using dinitrophenol, the athlete will radiate so much heat that it is uncomfortable to be within any proximity of them. Luckily, this heat does not fully contribute to body temperature increases, and is instead thrown off from the entire body surface, particularly the head. As a result, adequate doses of DNP will usually only elevate body temperature by about 1-1.5ºC. This is a good thing for your central nervous system and other delicate tissues; if the heat produced by ATP contributed in a more direct matter to body temperature, effective doses for fat loss would cause supraphysiological body temperature increases on a level unwitnessed at this time. Nonetheless, overheating is a very real danger; this and other side effects shall now be addressed.

Risks/Side Effects

Hearing all of these wonderful things probably has you wondering what the side effects and risks are. They are quite formidable and contribute to making DNP one of the most intolerable (though effective) drugs used in bodybuilding. Starting with the most significant, and descending in importance, are the following risks and side effects of DNP use.

Risks:

Overheating – There is no upper limit to DNP’s body temperature increase, meaning that one may literally “cook from the inside” if they take too much. Dosage considerations will be given later, but even an overdose of 4-6 times the recommended dosage may be lethal. Much smaller overdoses may result in damage to the brain and/or other body systems.

Carcinogenesis – Phenols in general are reputed to be carcinogenic. Although 2,4-dinitrophenol has never been implicated in a cancer diagnosis, some are nonetheless concerned, and understandably so. In addition to the inherent carcinogenic potential caused by its status as a phenol, production of free radicals and the release of various compounds stored in adipose tissue stores during DNP’s rapid oxidation of fat may also potentially be harmful.

Death – This is self-explanatory and has occurred with several bodybuilders who chose to use this compound.

Side Effects:

Discomfort and sweating – This is the single most noticeable effect of DNP use, both by the user and those around him/her. Even in the winter, while indoors at ambient temperatures, one may expect his or her shirt to be completely soaked through with sweat. Those with jobs requiring formal or semi-formal apparel are advised to consider other means of fat loss (or a new job, if preferred). Other obvious considerations lie in the areas of social life, personal appearance, etc. and the user must prioritize.

Insomnia – Second in frequency of reports to sweating and discomfort is insomnia; this may be at least partially attributed to discomfort. Possible means of countering this include such supplements as Valerian root or melatonin. Alternatively, one may deal with this via prescription or OTC sleep medications or GHB-A precursors. However, these may be addictive if used on a regular basis and if their use may be avoided, by all means abstain from using them.

Yellow bodily fluids - Some don’t notice this, but others find that all of their bodily fluids take on a yellowish appearance. Urine is a darker yellow, and even semen and vaginal secretions may be affected. According to current knowledge, this is not known to be harmful in and of itself.

Muscle Soreness – This is yet another thing that may be minimized via cerebral function. Dan Duchaine has recommended using a weight such as to allow no fewer than 15 reps per set of any weight training workout; judging from anecdotal reports and personal experience, this seems to be good advice. Low levels of ATP are a cause of muscle soreness in and of itself; the additional factor of encumbered recovery mechanisms make extreme soreness (and if not careful, catabolism) quite possible.

Allergic Reactions – These are highly individualized but may be summarily discussed. Various reactions are common with DNP use, and approximately 10% of users will be extremely allergic to it. Allergic reactions can include hives, blisters, and/or inexplicable rashes. If you suffer any of these side effects, and they are extremely bothersome, it is the recommendation of the author to cease usage immediately. If so desired, another trial may be made at a later date with a lower dosage, but do not attempt to continue the drug cycle at that point.

Carbohydrate Cravings – To counter this, some methods will be touched on later. As with most diets, willpower is sometimes the single most important factor.]]> DNP (2,4-Dinitrophenol)

DNP (2,4-Dinitrophenol), an industrial chemical with various applications, has gained steady popularity as a fat loss tool. Boasting an astounding 50% increase in metabolic rate, it is able to contribute to reported fat losses of 10-12 pounds in 8 days of use. Classified as an “uncoupler of oxidative phosphorylation” medically, it is quite dangerous as there is no negative feedback system that may deal with overdoses. Specifically, there is no upper limit to the increase in body temperature that may be obtained with its use.

Introduction/History

Competitive bodybuilders and many others are continually on a quest for leanness. Used by the hardcore since Dan Duchaine’s reporting of it a couple years ago, DNP (2,4-Dinitrophenol) has managed to steadily gain popularity as a powerful tool for weight loss. Interestingly, DNP was first used to ignite TNT in the early 1900’s. In 1931 a study released by Stanford University declared that DNP was able to cause amazing weight loss; subsequently it found its way into many diet potions and medications; regulation was much less strict during this time than the present, and many of these products were available over the counter. Two years later DNP was banned by the FDA as a dieting agent due to its inclusion in many OTC dietary supplements. The FDA was a new organization at this time and acted in a rather brazen manner, with the absence of any set procedures for taking substances off the market. Granted, there was only a 1% incidence of cataracts over a large population (around 100,000); nonetheless it happened (although interestingly, exclusively women). However, there are now ways to counter this which will be covered thoroughly.

The comparisons to the current drugs used for dieting are astounding, at least in terms of thermogenesis. While the ECA stack has been shown to provide approximately a 3% increase in metabolic rate, DNP can deliver a relatively controlled 50% elevation in resting metabolic rate. The thermogenic aspect of clenbuterol, while sometimes overestimated due to the high CNS stimulation that yields a “wired” feeling, can vary according to prior exposure to various amphetamine-like compounds and certainly is not much greater than that of ECA. DNP does not have the anorectic effects of ephedrine or other thermogenic agents; rather, it tends to increase hunger, particularly appetite for carbohydrates. This problem is easily solved with appetite suppressants, and one may even use ECA itself for this purpose while on DNP.

Molecular Basis for Efficacy

DNP accomplishes the astounding boost in metabolic rate via inhibition of the F0F1 ATP synthase molecule, located in the inner wall of each mitochondrion. While the electron transport chain still functions to pump hydrogen ions into the intermembrane space, the coupling of the proton gradient to ATP production is rendered impossible by DNP. As a result, ATP production is dramatically reduced, and the energy is instead thrown off as heat. This results in an astounding production of heat; when using dinitrophenol, the athlete will radiate so much heat that it is uncomfortable to be within any proximity of them. Luckily, this heat does not fully contribute to body temperature increases, and is instead thrown off from the entire body surface, particularly the head. As a result, adequate doses of DNP will usually only elevate body temperature by about 1-1.5ºC. This is a good thing for your central nervous system and other delicate tissues; if the heat produced by ATP contributed in a more direct matter to body temperature, effective doses for fat loss would cause supraphysiological body temperature increases on a level unwitnessed at this time. Nonetheless, overheating is a very real danger; this and other side effects shall now be addressed.

Risks/Side Effects

Hearing all of these wonderful things probably has you wondering what the side effects and risks are. They are quite formidable and contribute to making DNP one of the most intolerable (though effective) drugs used in bodybuilding. Starting with the most significant, and descending in importance, are the following risks and side effects of DNP use.

Risks:

Overheating – There is no upper limit to DNP’s body temperature increase, meaning that one may literally “cook from the inside” if they take too much. Dosage considerations will be given later, but even an overdose of 4-6 times the recommended dosage may be lethal. Much smaller overdoses may result in damage to the brain and/or other body systems.

Carcinogenesis – Phenols in general are reputed to be carcinogenic. Although 2,4-dinitrophenol has never been implicated in a cancer diagnosis, some are nonetheless concerned, and understandably so. In addition to the inherent carcinogenic potential caused by its status as a phenol, production of free radicals and the release of various compounds stored in adipose tissue stores during DNP’s rapid oxidation of fat may also potentially be harmful.

Death – This is self-explanatory and has occurred with several bodybuilders who chose to use this compound.

Side Effects:

Discomfort and sweating – This is the single most noticeable effect of DNP use, both by the user and those around him/her. Even in the winter, while indoors at ambient temperatures, one may expect his or her shirt to be completely soaked through with sweat. Those with jobs requiring formal or semi-formal apparel are advised to consider other means of fat loss (or a new job, if preferred). Other obvious considerations lie in the areas of social life, personal appearance, etc. and the user must prioritize.

Insomnia – Second in frequency of reports to sweating and discomfort is insomnia; this may be at least partially attributed to discomfort. Possible means of countering this include such supplements as Valerian root or melatonin. Alternatively, one may deal with this via prescription or OTC sleep medications or GHB-A precursors. However, these may be addictive if used on a regular basis and if their use may be avoided, by all means abstain from using them.

Yellow bodily fluids - Some don’t notice this, but others find that all of their bodily fluids take on a yellowish appearance. Urine is a darker yellow, and even semen and vaginal secretions may be affected. According to current knowledge, this is not known to be harmful in and of itself.

Muscle Soreness – This is yet another thing that may be minimized via cerebral function. Dan Duchaine has recommended using a weight such as to allow no fewer than 15 reps per set of any weight training workout; judging from anecdotal reports and personal experience, this seems to be good advice. Low levels of ATP are a cause of muscle soreness in and of itself; the additional factor of encumbered recovery mechanisms make extreme soreness (and if not careful, catabolism) quite possible.

Allergic Reactions – These are highly individualized but may be summarily discussed. Various reactions are common with DNP use, and approximately 10% of users will be extremely allergic to it. Allergic reactions can include hives, blisters, and/or inexplicable rashes. If you suffer any of these side effects, and they are extremely bothersome, it is the recommendation of the author to cease usage immediately. If so desired, another trial may be made at a later date with a lower dosage, but do not attempt to continue the drug cycle at that point.

Carbohydrate Cravings – To counter this, some methods will be touched on later. As with most diets, willpower is sometimes the single most important factor.]]> https://hypermuscles.com/showthread.php?tid=4855 Sun, 20 Apr 2014 01:37:01 +0000 13uie67]]> https://hypermuscles.com/showthread.php?tid=4855 https://hypermuscles.com/showthread.php?tid=4854 Sun, 20 Apr 2014 00:47:20 +0000 13uie67]]> https://hypermuscles.com/showthread.php?tid=4854 https://hypermuscles.com/showthread.php?tid=4133 Fri, 29 Mar 2013 19:37:05 +0000 Cornish_Celt]]> https://hypermuscles.com/showthread.php?tid=4133 Chemical Structure: 17beta-Hydroxy-17-methylestra-4,9,11-trien-3-one
Chemical Formula: C19H24O2
Molecular Weight: 284.3974
Active Life: four to six hours
Anabolic/Androgenic Ratio: approximately 12 000/6 000



Methyltrienolone is essentially the same compound as trenbolone that has gone under 17 alpha alkylation so that it can remain active after oral administration. So in a basic sense, methyltrienolone offers all of the advantages of trenbolone with the added bonus of being orally active. However, that extra benefit comes with a hefty price when it comes to hepatoxicity as will be demonstrated below.

Like trenbolone methyltrienolone has an extremely strong binding affinity for the androgen receptor as well, even surpassing that of testosterone. This of course supports the assertion that trenbolone is extremely anabolic as by binding to the androgen receptor a compound is able to activate the anabolic mechanisms that are dependent upon the androgen receptor, one of the many ways that anabolic steroids aid muscle growth. Androgen receptors also exist in adipose tissue. When stimulated by way of a compound such as methyltrienolone binding to them, this can result in a higher then normal lipolytic action (1). So not only does this drug help to build muscle, it can help to burn fat.

Another rather unique characteristic of methyltrienolone is its anti-catabolic abilities. Methyltrienolone binds with the receptors that interact with glucocorticoid hormones, these being catabolic hormones (2). By being able to inhibit cortisol and some other catabolic hormones in the body methyltrienolone is ideal for those users that are attempting to reduce body fat as the compound will help to minimize muscle wasting when running a calorie deficit.


Use/Dosing

Methyltrienolone was originally developed by a French pharmaceutical company, but never commercially produced due to its severe hepatoxic effects. That should indicate how truly harsh this drug is. For this reason it is important that users use caution when dosing this drug and ensure that they keep their cycles of it to brief periods of time. This would also include the exclusion of other steroids that are overly hepatoxic, such as 17 alpha alkylated oral steroids.

In terms of cycle duration, four weeks is the standard length that most users limit themselves too if not shorter. Any extension of this time would absolutely necessitate continuous blood tests conducted by a doctor, something that is a good idea no matter how long a user intends to run this drug. Of course, individual response to the drug and the liver function of a user would also factor into how well a user is able to tolerate methyltrienolone and thereby run the drug.

As for dosing, since little research has been conducted using methyltrienolone since its first production we are left to use anecdotal information to determine exactly how much of the compound one should administer to see its benefits as well as limiting the side effects. Doses ranging from 400-800 micrograms for male users are quite normal for most. Females are not recommended to administer this drug, as will be discussed in the section below. Of course like all drugs doses much higher then these have been run. This also has led to a much higher reporting rate of negative side effects, including temporary liver conditions such as jaundice. For this reason it is recommended that users remain quite careful whenever initially dosing this compound, as well as any increases that they may make.


Risks/Side Effects

Similar to trenbolone, methyltrienolone does not exhibit any estrogenic activity and therefore estrogenic side effects are not a concern with this compound itself. It is also resistant to the 5 alpha reductase enzyme, but this is of little comfort to a user as methyltrienolone is already of the most androgenic drugs in common use by steroid users. For this reason androgenic side effects should be expected by most users that undertake a cycle of this drug. Prostate enlargement and oily skin/acne are commonly reported by users. The effect of the drug on the hair of the user should also close to that of trenbolone. Anecdotally many users have reported that trenbolone is one of, if not the, harshest compound for losing one's hair. The same can be said of methyltrienolone. If a user is genetically predisposed to male pattern baldness he may want to avoid this compound.

Having listed the harsh androgenic nature and side effects associated with methyltrienolone, it should come as no surpirse that women are not recommended to use this compound. The usual virilizing effects such as deepening of the voice, body/facial hair growth, and enlargement of the clitoris, among others are likely to cause problems for female users. These effects can appear at even relatively low doses as has been proven in animal studies (3). Methyltrienolone is not a compound that women should attempt to administer.

Now due to the lack of estrogenic side effects associated with methyltrienolone it would seem that users would have little to worry about in terms of side effects like gynecomastia, water retention, etc. However one again like trenbolone, methyltrienolone is a progestin, meaning that it has the ability to bind to receptors of the female sex hormone progesterone (4). Also, like other 19-nor compounds methyltrienolone increases prolactin levels. Side effects related to these reactions can include breast growth and lactation. The drug also has the ability to help enhance any estrogenic side effects that may results from aromatizing drugs that the user is administering concurrently. This is obviously something to take into consideration when deciding what ancillary drugs to use during a cycle that includes methyltrienolone. To prevent side effects as they relate to increased prolactin levels a user can use several compounds including bromocriptine, vitamin b6, and/or cabergoline. Letrozole can also be used to lower progesterone levels.

Being a progestin, methyltrienolone also has a dramatic effect on users’ natural testosterone production. Much in the same way that trenbolone and nandrolone do, methyltrienolone can suppress the natural production of testosterone for an extended period of time. For this reason it is advisable that users use testosterone in conjunction with methyltrienolone even during short cycles if they wish to avoid sexual dysfunction, libido problems, or mental side effects associated with a lack of testosterone. There have been some animal studies that have shown that methyltrienolone can actually increase libido in some cases (5), but others have found the opposite effect to be true as well (6). As a precautionary measure, testosterone supplementation may be a good protocol to follow.

As stated earlier in this profile, methyltrienolone was deemed to be to hepatoxic for commercial human use by the company that originally developed it. As a 17 alpha alkylated steroid, it would be assumed that the drug would put an additional strain on the liver of a user. However it seems that methyltrienolone is one of the harsher steroids in terms of hepatoxicity. For this reason, it can be expected that the liver values of a user will become elevated if he or she uses methyltrienolone for any moderate period of time. In fact liver damage could be a significant risk if doses or durations of cycling the drug range outside of excepted standards of if the user has any liver abnormalities. For this reason using other 17 alpha alkylated steroids at the same time as methyltrienolone, or even relatively close to the same time as the drug, is considered to a risk that one should not endeavour to take.


References

1. Sjogren J, Li M, Bjorntorp P. Androgen hormone binding to adipose tissue in rats. Biochim Biophys Acta. 1995 May 11;1244(1):117-20.

2. Ho-Kim MA, Tremblay RR, Dube JY. Binding of methyltrienolone to glucocorticoid receptors in rat muscle cytosol. Endocrinology. 1981 Nov;109(5):1418-23.

3. Lax ER, Baumann P, Schriefers H. Changes in the activities of microsomal enzymes involved in hepatic steroid metabolism in the rat after administration of androgenic, estrogenic, progestational, anabolic and catatoxic steroids. Biochem Pharmacol. 1984 Apr 15;33(8):1235-41.

4. Dube JY, Tremblay RR, Chapdelaine P. Binding of methyltrienolone to various androgen-dependent and androgen-responsive tissues in four animal species. Horm Res. 1976;7(6):333-40.

5. Sodersten P, Gustafsson JA. Activation of sexual behaviour in castrated rats with the synthetic androgen 17 beta-hydroxy-17 alpha-methyl-estra-4,9,11-triene-3-one (R 1881). J Endocrinol. 1980 Nov;87(2):279-83.

6. Baum MJ, Kingsbury PA, Erskine MS. Failure of the synthetic androgen 17 beta-hydroxy-17 alpha-methyl-estra-4,9,11-triene-3-one (methyltrienolone, R1881) to duplicate the activational effect of testosterone on mating in castrated male rats. J Endocrinol. 1987 Apr;113(1):15-20.]]> Chemical Structure: 17beta-Hydroxy-17-methylestra-4,9,11-trien-3-one
Chemical Formula: C19H24O2
Molecular Weight: 284.3974
Active Life: four to six hours
Anabolic/Androgenic Ratio: approximately 12 000/6 000



Methyltrienolone is essentially the same compound as trenbolone that has gone under 17 alpha alkylation so that it can remain active after oral administration. So in a basic sense, methyltrienolone offers all of the advantages of trenbolone with the added bonus of being orally active. However, that extra benefit comes with a hefty price when it comes to hepatoxicity as will be demonstrated below.

Like trenbolone methyltrienolone has an extremely strong binding affinity for the androgen receptor as well, even surpassing that of testosterone. This of course supports the assertion that trenbolone is extremely anabolic as by binding to the androgen receptor a compound is able to activate the anabolic mechanisms that are dependent upon the androgen receptor, one of the many ways that anabolic steroids aid muscle growth. Androgen receptors also exist in adipose tissue. When stimulated by way of a compound such as methyltrienolone binding to them, this can result in a higher then normal lipolytic action (1). So not only does this drug help to build muscle, it can help to burn fat.

Another rather unique characteristic of methyltrienolone is its anti-catabolic abilities. Methyltrienolone binds with the receptors that interact with glucocorticoid hormones, these being catabolic hormones (2). By being able to inhibit cortisol and some other catabolic hormones in the body methyltrienolone is ideal for those users that are attempting to reduce body fat as the compound will help to minimize muscle wasting when running a calorie deficit.


Use/Dosing

Methyltrienolone was originally developed by a French pharmaceutical company, but never commercially produced due to its severe hepatoxic effects. That should indicate how truly harsh this drug is. For this reason it is important that users use caution when dosing this drug and ensure that they keep their cycles of it to brief periods of time. This would also include the exclusion of other steroids that are overly hepatoxic, such as 17 alpha alkylated oral steroids.

In terms of cycle duration, four weeks is the standard length that most users limit themselves too if not shorter. Any extension of this time would absolutely necessitate continuous blood tests conducted by a doctor, something that is a good idea no matter how long a user intends to run this drug. Of course, individual response to the drug and the liver function of a user would also factor into how well a user is able to tolerate methyltrienolone and thereby run the drug.

As for dosing, since little research has been conducted using methyltrienolone since its first production we are left to use anecdotal information to determine exactly how much of the compound one should administer to see its benefits as well as limiting the side effects. Doses ranging from 400-800 micrograms for male users are quite normal for most. Females are not recommended to administer this drug, as will be discussed in the section below. Of course like all drugs doses much higher then these have been run. This also has led to a much higher reporting rate of negative side effects, including temporary liver conditions such as jaundice. For this reason it is recommended that users remain quite careful whenever initially dosing this compound, as well as any increases that they may make.


Risks/Side Effects

Similar to trenbolone, methyltrienolone does not exhibit any estrogenic activity and therefore estrogenic side effects are not a concern with this compound itself. It is also resistant to the 5 alpha reductase enzyme, but this is of little comfort to a user as methyltrienolone is already of the most androgenic drugs in common use by steroid users. For this reason androgenic side effects should be expected by most users that undertake a cycle of this drug. Prostate enlargement and oily skin/acne are commonly reported by users. The effect of the drug on the hair of the user should also close to that of trenbolone. Anecdotally many users have reported that trenbolone is one of, if not the, harshest compound for losing one's hair. The same can be said of methyltrienolone. If a user is genetically predisposed to male pattern baldness he may want to avoid this compound.

Having listed the harsh androgenic nature and side effects associated with methyltrienolone, it should come as no surpirse that women are not recommended to use this compound. The usual virilizing effects such as deepening of the voice, body/facial hair growth, and enlargement of the clitoris, among others are likely to cause problems for female users. These effects can appear at even relatively low doses as has been proven in animal studies (3). Methyltrienolone is not a compound that women should attempt to administer.

Now due to the lack of estrogenic side effects associated with methyltrienolone it would seem that users would have little to worry about in terms of side effects like gynecomastia, water retention, etc. However one again like trenbolone, methyltrienolone is a progestin, meaning that it has the ability to bind to receptors of the female sex hormone progesterone (4). Also, like other 19-nor compounds methyltrienolone increases prolactin levels. Side effects related to these reactions can include breast growth and lactation. The drug also has the ability to help enhance any estrogenic side effects that may results from aromatizing drugs that the user is administering concurrently. This is obviously something to take into consideration when deciding what ancillary drugs to use during a cycle that includes methyltrienolone. To prevent side effects as they relate to increased prolactin levels a user can use several compounds including bromocriptine, vitamin b6, and/or cabergoline. Letrozole can also be used to lower progesterone levels.

Being a progestin, methyltrienolone also has a dramatic effect on users’ natural testosterone production. Much in the same way that trenbolone and nandrolone do, methyltrienolone can suppress the natural production of testosterone for an extended period of time. For this reason it is advisable that users use testosterone in conjunction with methyltrienolone even during short cycles if they wish to avoid sexual dysfunction, libido problems, or mental side effects associated with a lack of testosterone. There have been some animal studies that have shown that methyltrienolone can actually increase libido in some cases (5), but others have found the opposite effect to be true as well (6). As a precautionary measure, testosterone supplementation may be a good protocol to follow.

As stated earlier in this profile, methyltrienolone was deemed to be to hepatoxic for commercial human use by the company that originally developed it. As a 17 alpha alkylated steroid, it would be assumed that the drug would put an additional strain on the liver of a user. However it seems that methyltrienolone is one of the harsher steroids in terms of hepatoxicity. For this reason, it can be expected that the liver values of a user will become elevated if he or she uses methyltrienolone for any moderate period of time. In fact liver damage could be a significant risk if doses or durations of cycling the drug range outside of excepted standards of if the user has any liver abnormalities. For this reason using other 17 alpha alkylated steroids at the same time as methyltrienolone, or even relatively close to the same time as the drug, is considered to a risk that one should not endeavour to take.


References

1. Sjogren J, Li M, Bjorntorp P. Androgen hormone binding to adipose tissue in rats. Biochim Biophys Acta. 1995 May 11;1244(1):117-20.

2. Ho-Kim MA, Tremblay RR, Dube JY. Binding of methyltrienolone to glucocorticoid receptors in rat muscle cytosol. Endocrinology. 1981 Nov;109(5):1418-23.

3. Lax ER, Baumann P, Schriefers H. Changes in the activities of microsomal enzymes involved in hepatic steroid metabolism in the rat after administration of androgenic, estrogenic, progestational, anabolic and catatoxic steroids. Biochem Pharmacol. 1984 Apr 15;33(8):1235-41.

4. Dube JY, Tremblay RR, Chapdelaine P. Binding of methyltrienolone to various androgen-dependent and androgen-responsive tissues in four animal species. Horm Res. 1976;7(6):333-40.

5. Sodersten P, Gustafsson JA. Activation of sexual behaviour in castrated rats with the synthetic androgen 17 beta-hydroxy-17 alpha-methyl-estra-4,9,11-triene-3-one (R 1881). J Endocrinol. 1980 Nov;87(2):279-83.

6. Baum MJ, Kingsbury PA, Erskine MS. Failure of the synthetic androgen 17 beta-hydroxy-17 alpha-methyl-estra-4,9,11-triene-3-one (methyltrienolone, R1881) to duplicate the activational effect of testosterone on mating in castrated male rats. J Endocrinol. 1987 Apr;113(1):15-20.]]> https://hypermuscles.com/showthread.php?tid=1219 Mon, 17 Jan 2011 06:25:55 +0000 Cornish_Celt]]> https://hypermuscles.com/showthread.php?tid=1219 Cytomel / T3

Characteristics:
Cytomel is not a steroid, but more a of a cutting aid. It's a synthetic form of the thyroid hormone tri-iodio-thyronine or T3, made up of a metabolite of the amino acid tyrosine and 3 iodine ions. In the body it in turn is made from another hormone, T4, which is secreted by the thyroid under influence of the pituitary hormone TSH (Thyroid stimulating hormone). If a shortage of either TSH or T4 is noted, usually doctors may opt for a replacement therapy. These days the most common prescription is synthetic T4 (synthroid), but in more severe cases of permanent thyroid dysfunction, the choice is given to Cytomel. Simply because T4 is mostly active through its conversion to T3 and T3 is 4-5 times stronger than T4 on a µg for µg basis.
In bodybuilding circles Cytomel is mostly used as fat-loss drug. Thyroid hormones are often referred to as the metabolic regulators of the body. High levels of T3 speed up the metabolism of an individual, allowing him to burn more calories and use calories more sufficiently. Generally ectopmorphic body-types have very high thyroid levels and in some cases a slight undiagnosed form of hyperthyroidism. Both hyper-and hypothyroidism can have severe consequences on an individual, such as goiters and other nasty stuff, so messing with your thyroid is not something I would advise to beginners. As with insulin, misuse of this compound can leave you dependent on exogenous T3 for the rest of your life (remember Frank Zane?). So some caution and research is required before putting Cytomel in your body. Generally cycles should be limited to 4-6 weeks tops, I recommend 3 and alternating cycles with 3-week cycles of clenbuterol. But most importantly, to avoid a crash or a shock to the thyroid function doses need to be built up over time and tapered off again. More so for cytomel than for any other drug in existence.
In his book, Anabolics 2002, Bill Llewellyn says that Cytomel is not a drug to start off on, and that use of milder drugs like T4 (Synthroid) or triacana can help ease a person into the use of T3. I'm inclined to disagree here however. Triacana is weak compound and I find of little use. Its not easily found anymore and not cheap either. T4 is basically similar to Cytomel except that its weaker. Something that users normally compensate with higher doses and sends them down a similar lane as simply using cytomel. Agreed, cytomel is NOT a drug for beginners, but with adequate research, experience with diet and some self-control, I don't see why cytomel shouldn't be the first thyoid compound used. But for recreational users looking for a fatburner, I still suggest using clenbuterol over cytomel for all intents and purposes. Cytomel is much more powerful, but clenbuterol is a lot safer for use. The results are easier to maintain with clenbuterol as well. Negative feedback in the thyroid may decrease natural levels of T3 in the body, causing a decrease of metabolic rate after coming off a cycle of T3. That can cause a rebound effect during which a lot of weight is gained back.
For competitive bodybuilders Cytomel is an almost unmissable aid in contest preparation, along with clenbuterol and non-aromatizing steroids such as stanazolol, trenbolone, methenolone and so forth...

Stacking and Use:
It can be stacked or alternated with clenbuterol. I usually recommend to alternate, three weeks clen with three weeks cytomel, since clen loses most of its benefits after a short period of time and using cytomel for extended time-periods will increase the risk of permanent thyroid failure. Neither drug is terribly expensive so I see no problem in this. Some opt to use them together for 3-4 weeks, and then use an over the counter ECA stack to bridge with for an equal period of time, but I'm not such a big fan of that. Which naturally doesn't mean its not effective, that's just a personal opinion. Running it for three weeks, one could choose for a schedule as follows: 25/25/25/50/50/50/75/75/75/100/100/100/75/75/75/50/50/50/25/25/25 µg/day. If taken for 4 weeks, then run each dose for 4 days, 5 weeks then each dose for 5 days and so on. It is extremely important that the doses are tapered on and off and that a cycle never exceeds 6 weeks at the most.
As far as adding products, no ancillaries are needed, but its highly recommended that this is only used when anabolic/androgenic steroids are also being used. First of all the extra free calories work with the steroids to enhance results, but also because an increased level of thyroid hormones can be extremely catabolic and the use of anabolic compounds to counter muscle loss is a requirement here.]]> Cytomel / T3

Characteristics:
Cytomel is not a steroid, but more a of a cutting aid. It's a synthetic form of the thyroid hormone tri-iodio-thyronine or T3, made up of a metabolite of the amino acid tyrosine and 3 iodine ions. In the body it in turn is made from another hormone, T4, which is secreted by the thyroid under influence of the pituitary hormone TSH (Thyroid stimulating hormone). If a shortage of either TSH or T4 is noted, usually doctors may opt for a replacement therapy. These days the most common prescription is synthetic T4 (synthroid), but in more severe cases of permanent thyroid dysfunction, the choice is given to Cytomel. Simply because T4 is mostly active through its conversion to T3 and T3 is 4-5 times stronger than T4 on a µg for µg basis.
In bodybuilding circles Cytomel is mostly used as fat-loss drug. Thyroid hormones are often referred to as the metabolic regulators of the body. High levels of T3 speed up the metabolism of an individual, allowing him to burn more calories and use calories more sufficiently. Generally ectopmorphic body-types have very high thyroid levels and in some cases a slight undiagnosed form of hyperthyroidism. Both hyper-and hypothyroidism can have severe consequences on an individual, such as goiters and other nasty stuff, so messing with your thyroid is not something I would advise to beginners. As with insulin, misuse of this compound can leave you dependent on exogenous T3 for the rest of your life (remember Frank Zane?). So some caution and research is required before putting Cytomel in your body. Generally cycles should be limited to 4-6 weeks tops, I recommend 3 and alternating cycles with 3-week cycles of clenbuterol. But most importantly, to avoid a crash or a shock to the thyroid function doses need to be built up over time and tapered off again. More so for cytomel than for any other drug in existence.
In his book, Anabolics 2002, Bill Llewellyn says that Cytomel is not a drug to start off on, and that use of milder drugs like T4 (Synthroid) or triacana can help ease a person into the use of T3. I'm inclined to disagree here however. Triacana is weak compound and I find of little use. Its not easily found anymore and not cheap either. T4 is basically similar to Cytomel except that its weaker. Something that users normally compensate with higher doses and sends them down a similar lane as simply using cytomel. Agreed, cytomel is NOT a drug for beginners, but with adequate research, experience with diet and some self-control, I don't see why cytomel shouldn't be the first thyoid compound used. But for recreational users looking for a fatburner, I still suggest using clenbuterol over cytomel for all intents and purposes. Cytomel is much more powerful, but clenbuterol is a lot safer for use. The results are easier to maintain with clenbuterol as well. Negative feedback in the thyroid may decrease natural levels of T3 in the body, causing a decrease of metabolic rate after coming off a cycle of T3. That can cause a rebound effect during which a lot of weight is gained back.
For competitive bodybuilders Cytomel is an almost unmissable aid in contest preparation, along with clenbuterol and non-aromatizing steroids such as stanazolol, trenbolone, methenolone and so forth...

Stacking and Use:
It can be stacked or alternated with clenbuterol. I usually recommend to alternate, three weeks clen with three weeks cytomel, since clen loses most of its benefits after a short period of time and using cytomel for extended time-periods will increase the risk of permanent thyroid failure. Neither drug is terribly expensive so I see no problem in this. Some opt to use them together for 3-4 weeks, and then use an over the counter ECA stack to bridge with for an equal period of time, but I'm not such a big fan of that. Which naturally doesn't mean its not effective, that's just a personal opinion. Running it for three weeks, one could choose for a schedule as follows: 25/25/25/50/50/50/75/75/75/100/100/100/75/75/75/50/50/50/25/25/25 µg/day. If taken for 4 weeks, then run each dose for 4 days, 5 weeks then each dose for 5 days and so on. It is extremely important that the doses are tapered on and off and that a cycle never exceeds 6 weeks at the most.
As far as adding products, no ancillaries are needed, but its highly recommended that this is only used when anabolic/androgenic steroids are also being used. First of all the extra free calories work with the steroids to enhance results, but also because an increased level of thyroid hormones can be extremely catabolic and the use of anabolic compounds to counter muscle loss is a requirement here.]]> https://hypermuscles.com/showthread.php?tid=1218 Mon, 17 Jan 2011 06:22:53 +0000 Cornish_Celt]]> https://hypermuscles.com/showthread.php?tid=1218 Clenbuterol

Characteristics:
Clenbuterol is a very widely used drug and has quite a reputation. A good one among athletes and recreational users, and a very bad one among those people who know very little about illegal performance enhancing aids. Its not a steroid. In fact, the only medical use for which clenbuterol is generally prescribed (and now being less and less prescribed thanks to its illegitimate use) is for obstructions of the air-way. People with chronic breathing disorders like asthma use this as a bronchodilator to make breathing easier. But its only one of the many things that can be achieved with the use of clenbuterol.
In terms of action this drug is best likened to the now also illegal ephedrine and its legal replacement, ma huang. All of them operate mainly by increasing the manufacture and secretion of catabolic hormones known as cathecholamines (like dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline)) which are secreted from the adrenal region. Now these hormones have a wide variety of functions. First of all they seem to alter the contractile characteristics of smooth muscle, but very specifically. Some will apparently be stimulated, and others inhibited. Amongst those inhibited, the smooth muscles in the bronchial tree, which explains its soothing effect in patients with breathing problems. What it also does is increase thermogenisis. This usually encompasses a rise in blood pressure, a stimulatory effect of the heart muscle and a resulting rise in body temperature.
Along with the reversing of the effects of insulin (and inhibiting the action of insulin) which results in a release of glycogen back into the blood stream as glucose and an inability to store or use more glycogen, it will increase the rate of protein and fat being burned in the body. For bodybuilders that appears to be the primary use of the drug. This thermogenisis and an increase in the rate of fat being burned usually has as a result that the metabolic rate of the subject its much higher and he burns more calories. This in turn results in loss of adipose tissue (the shedding of fat in other words) revealing a leaner physique with cuts and striations. The downside to this effect is that there is a concomitant rise in the rate of protein being burned. Where fat is robbed from the fatty tissue in the body, protein is generally robbed from the muscle. As with all catabolic hormones, in time muscle loss can and will occur. Which is why many opt to use this compound during a cycle of anabolic steroids that will help preserve the lean body mass while reducing the fat.
Among the other actions that cathecholamines have is an increase in aerobic capacity (facilitated by the easier breathing), a stimulation of the nervous system (facilitated by norepinephrine and acetylcholine release) and thus the skeletal muscle system, an increase in oxygen transportation (facilitated by the increased blood pressure) and an increase in vigil. These characteristics in turn combine to make this drug particularly interesting for athletes doing endurance sports and needing a boost. Especially in middle-long running numbers, this drug is widely abused and its no secret that in cycling circles clenbuterol in liquid form is combined with a painkiller and the drug EPO (synthetic erythropoeitin, a renal hormone) which increases the manufacture of red blood cells. It is then injected along the road, thereby avoiding positive tests prior to the race. Needless to say such a cocktail is very hazardous to the cardiovascular system. Just to demonstrate the wide use of this drug and its immense popularity among athletes, observe the US Olympic team. Exercise-induced asthma is an afflmiction that generally occurs in 3-7% of the population, and is in some rare cases treated with clenbuterol. In 2000 60% of US Olympic athletes claimed to have exercise-induced asthma and ALL of them were prescribed clenbuterol for this condition. An otherwise illegal drug, tolerated solely for this reason. And this while the Romanian gymnast Andrea Raducan was stripped of her gold medal for the 25 µg of norephedrine in her cold medicin she was taking...
In several animal studies1,2,3 Clenbuterol was also shown to act as an anabolic, believed to be able to impart muscle gains. This was never demonstrated in humans4 however, and there is more evidence that its effect on catabolic hormones invokes the opposite. In any case, the animal studies used much higher doses5 then one would safely recommend for humans. The late Dan Duchaine, by many held in high regard as a steroid guru and a former writer of the now defunct MM2K, believed it had something to do with the stimulation of a third beta receptor, which was different in humans as opposed to other mammals, and that this was the reason humans did not receive any anabolic benefits. As with most of what Dan said, this is very questionable, but one of many possible explanations in a debate that still rages on. Despite the many claims of other bodybuilders that still swear it has some form of anabolic action, I must say I've seen enough proof to the contrary to strongly advise against buying clenbuterol for promoting muscle mass. You may be more than sorely disappointed. Next time you see a 230 pound, 6 foot top-level cyclist, let me know and I may change my mind.
Clenbuterol, when used for its fat-burning properties is best used in a pyramid scheme. Slowly building up the dose may be more important that tapering off of it, as most first time users will rarely if ever know how they will react. Because of the effects on blood pressure its best to start with 20-40 µg per day and slowly work your way up increasing the dose every 3 days by 20 µg, to a maximum of 120-160 µg (most find 80 µg to be adequate). Its also best not used for long periods of time. Body homeostasis seems to negate the excitatory and inhibitive functions of clenbuterol over time, creating a complacency effect. It loses most of its nerve stimulation and fat burning benefits after 3-4 weeks, and using it longer on end would be futile. The user is best to discontinue use for an equal period of time and then recommence again.
Another thing people should be aware of is the inherent liver toxicity associated with clenbuterol use. When stacking with oral 17-alpha-alkylated steroids, accutane, anti-biotics or other hepatoxic elements, one should have his liver values checked by a licensed physician at regular points in time to avoid all problems. If you not a yellow discoloration of the skin cease use immediately and contact your doctor.

Stacking and Use:
Clenbuterol should be built up and tapered off gradually with dosage increases and decreases every 3-4 days and doses never exceeding 160 µg per day to be perfectly safe. Its mostly used for periods of 2-3 weeks then discontinued for equal periods of time to disallow the body to adapt to the effects of the drug. For fat-burning goals clenbuterol is often stacked with another fat-burning agent for quick effect, or alternated with another fat-burning agent by people who need to stay lean on a year-round basis. Usually cytomel (T3) is used for such purposes, with alternating cycles of 3 weeks each. If used together, cycles will not completely overlap, but differ slightly so as not to match the low doses with the low and the high doses with the high. A typical cycle for clenbuterol might be 3 weeks, with the daily amounts being: 40/40/40/60/60/60/80/80/80/100/100/100/80/80/80/60/60/60/40/40/40 µg/day.
Then stopping for three weeks and recommencing.
It's also commonly stacked with anabolic steroids. Usually non-aromatizing steroids that give the user a leaner and harder look, and allow for less water retention. They serve a main purpose of allowing the user to keep as much of his hard-earned muscle mass as he tries to shed the fat he has stocked up in the off-season with catabolic precursors such as clenbuterol. Clenbuterol is generally regarded as fairly safe6, hence its wide-spread use. It should be disadvised for all with blood pressure and/or previously diagnosed cardio-vascular problems. But most tolerate it quite well. By building up the dose over time they usually see when they've reached a dose that becomes too harsh. The use of clenbuterol will elicit higher body temperature, higher blood pressure and in some, especially at high doses, insomnia and jitters. Though these should not be nearly as pronounced with clenbuterol as they are with ephedrine and its legal counterpart ma huang. They are also easily remedied by shifting doses around so you don't take clenbuterol in the hours leading up to bedtime and most of it in pre-training phases when the drug can enhance your training vigor.
Another good match for clenbuterol in a stack is the plant derivative yohimbine Hcl. It does concern the standardized product yohimbine here and not the raw material yohimbe, which is useless. In small doses of 20-30 mg per day, it can stop the down-regulation of the noradrenaline feedback mechanisms, that usually inhibit the actions of noradrenaline by reducing receptor affinity. This has two important uses. The first is that the length of action of clenbuterol can be enhanced by a few hours when using it together with yohimbine Hcl (although it already has a considerable half-life time7 of 36 hours and one daily dose should suffice) , and the second is that concomitant use of yohimbine Hcl may allow clenbuterol to induce its fatburning aspects on a longer term than the normal 2-3 weeks, so it can be used for 5-6 weeks instead. Yohimbine Hcl is, at least for now still, a legal supplement that can be acquired for very little money from legal sources and supplement companies.]]> Clenbuterol

Characteristics:
Clenbuterol is a very widely used drug and has quite a reputation. A good one among athletes and recreational users, and a very bad one among those people who know very little about illegal performance enhancing aids. Its not a steroid. In fact, the only medical use for which clenbuterol is generally prescribed (and now being less and less prescribed thanks to its illegitimate use) is for obstructions of the air-way. People with chronic breathing disorders like asthma use this as a bronchodilator to make breathing easier. But its only one of the many things that can be achieved with the use of clenbuterol.
In terms of action this drug is best likened to the now also illegal ephedrine and its legal replacement, ma huang. All of them operate mainly by increasing the manufacture and secretion of catabolic hormones known as cathecholamines (like dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline)) which are secreted from the adrenal region. Now these hormones have a wide variety of functions. First of all they seem to alter the contractile characteristics of smooth muscle, but very specifically. Some will apparently be stimulated, and others inhibited. Amongst those inhibited, the smooth muscles in the bronchial tree, which explains its soothing effect in patients with breathing problems. What it also does is increase thermogenisis. This usually encompasses a rise in blood pressure, a stimulatory effect of the heart muscle and a resulting rise in body temperature.
Along with the reversing of the effects of insulin (and inhibiting the action of insulin) which results in a release of glycogen back into the blood stream as glucose and an inability to store or use more glycogen, it will increase the rate of protein and fat being burned in the body. For bodybuilders that appears to be the primary use of the drug. This thermogenisis and an increase in the rate of fat being burned usually has as a result that the metabolic rate of the subject its much higher and he burns more calories. This in turn results in loss of adipose tissue (the shedding of fat in other words) revealing a leaner physique with cuts and striations. The downside to this effect is that there is a concomitant rise in the rate of protein being burned. Where fat is robbed from the fatty tissue in the body, protein is generally robbed from the muscle. As with all catabolic hormones, in time muscle loss can and will occur. Which is why many opt to use this compound during a cycle of anabolic steroids that will help preserve the lean body mass while reducing the fat.
Among the other actions that cathecholamines have is an increase in aerobic capacity (facilitated by the easier breathing), a stimulation of the nervous system (facilitated by norepinephrine and acetylcholine release) and thus the skeletal muscle system, an increase in oxygen transportation (facilitated by the increased blood pressure) and an increase in vigil. These characteristics in turn combine to make this drug particularly interesting for athletes doing endurance sports and needing a boost. Especially in middle-long running numbers, this drug is widely abused and its no secret that in cycling circles clenbuterol in liquid form is combined with a painkiller and the drug EPO (synthetic erythropoeitin, a renal hormone) which increases the manufacture of red blood cells. It is then injected along the road, thereby avoiding positive tests prior to the race. Needless to say such a cocktail is very hazardous to the cardiovascular system. Just to demonstrate the wide use of this drug and its immense popularity among athletes, observe the US Olympic team. Exercise-induced asthma is an afflmiction that generally occurs in 3-7% of the population, and is in some rare cases treated with clenbuterol. In 2000 60% of US Olympic athletes claimed to have exercise-induced asthma and ALL of them were prescribed clenbuterol for this condition. An otherwise illegal drug, tolerated solely for this reason. And this while the Romanian gymnast Andrea Raducan was stripped of her gold medal for the 25 µg of norephedrine in her cold medicin she was taking...
In several animal studies1,2,3 Clenbuterol was also shown to act as an anabolic, believed to be able to impart muscle gains. This was never demonstrated in humans4 however, and there is more evidence that its effect on catabolic hormones invokes the opposite. In any case, the animal studies used much higher doses5 then one would safely recommend for humans. The late Dan Duchaine, by many held in high regard as a steroid guru and a former writer of the now defunct MM2K, believed it had something to do with the stimulation of a third beta receptor, which was different in humans as opposed to other mammals, and that this was the reason humans did not receive any anabolic benefits. As with most of what Dan said, this is very questionable, but one of many possible explanations in a debate that still rages on. Despite the many claims of other bodybuilders that still swear it has some form of anabolic action, I must say I've seen enough proof to the contrary to strongly advise against buying clenbuterol for promoting muscle mass. You may be more than sorely disappointed. Next time you see a 230 pound, 6 foot top-level cyclist, let me know and I may change my mind.
Clenbuterol, when used for its fat-burning properties is best used in a pyramid scheme. Slowly building up the dose may be more important that tapering off of it, as most first time users will rarely if ever know how they will react. Because of the effects on blood pressure its best to start with 20-40 µg per day and slowly work your way up increasing the dose every 3 days by 20 µg, to a maximum of 120-160 µg (most find 80 µg to be adequate). Its also best not used for long periods of time. Body homeostasis seems to negate the excitatory and inhibitive functions of clenbuterol over time, creating a complacency effect. It loses most of its nerve stimulation and fat burning benefits after 3-4 weeks, and using it longer on end would be futile. The user is best to discontinue use for an equal period of time and then recommence again.
Another thing people should be aware of is the inherent liver toxicity associated with clenbuterol use. When stacking with oral 17-alpha-alkylated steroids, accutane, anti-biotics or other hepatoxic elements, one should have his liver values checked by a licensed physician at regular points in time to avoid all problems. If you not a yellow discoloration of the skin cease use immediately and contact your doctor.

Stacking and Use:
Clenbuterol should be built up and tapered off gradually with dosage increases and decreases every 3-4 days and doses never exceeding 160 µg per day to be perfectly safe. Its mostly used for periods of 2-3 weeks then discontinued for equal periods of time to disallow the body to adapt to the effects of the drug. For fat-burning goals clenbuterol is often stacked with another fat-burning agent for quick effect, or alternated with another fat-burning agent by people who need to stay lean on a year-round basis. Usually cytomel (T3) is used for such purposes, with alternating cycles of 3 weeks each. If used together, cycles will not completely overlap, but differ slightly so as not to match the low doses with the low and the high doses with the high. A typical cycle for clenbuterol might be 3 weeks, with the daily amounts being: 40/40/40/60/60/60/80/80/80/100/100/100/80/80/80/60/60/60/40/40/40 µg/day.
Then stopping for three weeks and recommencing.
It's also commonly stacked with anabolic steroids. Usually non-aromatizing steroids that give the user a leaner and harder look, and allow for less water retention. They serve a main purpose of allowing the user to keep as much of his hard-earned muscle mass as he tries to shed the fat he has stocked up in the off-season with catabolic precursors such as clenbuterol. Clenbuterol is generally regarded as fairly safe6, hence its wide-spread use. It should be disadvised for all with blood pressure and/or previously diagnosed cardio-vascular problems. But most tolerate it quite well. By building up the dose over time they usually see when they've reached a dose that becomes too harsh. The use of clenbuterol will elicit higher body temperature, higher blood pressure and in some, especially at high doses, insomnia and jitters. Though these should not be nearly as pronounced with clenbuterol as they are with ephedrine and its legal counterpart ma huang. They are also easily remedied by shifting doses around so you don't take clenbuterol in the hours leading up to bedtime and most of it in pre-training phases when the drug can enhance your training vigor.
Another good match for clenbuterol in a stack is the plant derivative yohimbine Hcl. It does concern the standardized product yohimbine here and not the raw material yohimbe, which is useless. In small doses of 20-30 mg per day, it can stop the down-regulation of the noradrenaline feedback mechanisms, that usually inhibit the actions of noradrenaline by reducing receptor affinity. This has two important uses. The first is that the length of action of clenbuterol can be enhanced by a few hours when using it together with yohimbine Hcl (although it already has a considerable half-life time7 of 36 hours and one daily dose should suffice) , and the second is that concomitant use of yohimbine Hcl may allow clenbuterol to induce its fatburning aspects on a longer term than the normal 2-3 weeks, so it can be used for 5-6 weeks instead. Yohimbine Hcl is, at least for now still, a legal supplement that can be acquired for very little money from legal sources and supplement companies.]]> https://hypermuscles.com/showthread.php?tid=1217 Mon, 17 Jan 2011 06:19:21 +0000 Cornish_Celt]]> https://hypermuscles.com/showthread.php?tid=1217 Oral-Turinabol-Tbol

Oral-Turinabol
Chemical Name: 4-chlorodehydromethyltestosterone
Drug Class: Oral Anabolic Steroid

Oral Turinabol (4-chlorodehydromethyltestosterone, commonly called “OT” or “T-bol”) has recently experienced an explosion of popularity due to its recent (re)release by British Dragon, and the subsequent game of follow-the-leader played by most underground labs. It was developed by scientists in East Germany, and is actually Dianabol (a dehydro version of testosterone) with a 4-chloro modification. The 4-chloro modification is also seen on “Clostebol” although that particular drug lacks the 1-2 double carbon bond that Dianabol and Turinabol both have. The 4-chloro modification actually makes the compound totally resistant to the aromatase enzyme (1), so users typically equate T-bol to Dianabol, but without the water retention. This is a very good comparison, actually, although it needs to be stated that weight gained with this drug will be significantly less than what is gained with D-bol.
The similarities are actually quite numerous, as they have also both been 17-alpha-alkylated (a carbon atom was added at the 17th position) to survive the first pass through the liver, and therefore be orally active. This, of course elevates liver enzyme activity. If I were to quantify the gains one experiences from this compound, I would say that it’s half way between Anavar and Dianabol, and therefore a perfect addition to either bulking or cutting cycles.

Another interesting effect of OT is that it would appear to have the ability to reduce Sex Hormone Binding Globulin (2)(3)to other steroids. This is important because that enzyme, when bound to testosterone, makes the latter un-bioavailable. This may also seem to indicate that OT may have synergy with other steroids, since it has this ability to reduce SHBG and thus free up more testosterone for use in your body, and prevent other steroids from becoming bound also.
The only negative thing I have read concerning OT is that in high doses (10+mg) have caused virilization in women.(4) However, the women I know who have actually used this drug haven’t reported anything like that. In fact, most women I know who have used it experienced much more positive effects from than men, as very little of this compound is actually needed to produce results in women.

The popularity of this drug in the East German’s gold medal winning cycles probably contributes quite a bit to it’s popularity, and unfortunately to its price also. Typically, although this drug is easily found on the black market, it’s also in relatively high demand, and that keeps the price stable- and high.]]> Oral-Turinabol-Tbol

Oral-Turinabol
Chemical Name: 4-chlorodehydromethyltestosterone
Drug Class: Oral Anabolic Steroid

Oral Turinabol (4-chlorodehydromethyltestosterone, commonly called “OT” or “T-bol”) has recently experienced an explosion of popularity due to its recent (re)release by British Dragon, and the subsequent game of follow-the-leader played by most underground labs. It was developed by scientists in East Germany, and is actually Dianabol (a dehydro version of testosterone) with a 4-chloro modification. The 4-chloro modification is also seen on “Clostebol” although that particular drug lacks the 1-2 double carbon bond that Dianabol and Turinabol both have. The 4-chloro modification actually makes the compound totally resistant to the aromatase enzyme (1), so users typically equate T-bol to Dianabol, but without the water retention. This is a very good comparison, actually, although it needs to be stated that weight gained with this drug will be significantly less than what is gained with D-bol.
The similarities are actually quite numerous, as they have also both been 17-alpha-alkylated (a carbon atom was added at the 17th position) to survive the first pass through the liver, and therefore be orally active. This, of course elevates liver enzyme activity. If I were to quantify the gains one experiences from this compound, I would say that it’s half way between Anavar and Dianabol, and therefore a perfect addition to either bulking or cutting cycles.

Another interesting effect of OT is that it would appear to have the ability to reduce Sex Hormone Binding Globulin (2)(3)to other steroids. This is important because that enzyme, when bound to testosterone, makes the latter un-bioavailable. This may also seem to indicate that OT may have synergy with other steroids, since it has this ability to reduce SHBG and thus free up more testosterone for use in your body, and prevent other steroids from becoming bound also.
The only negative thing I have read concerning OT is that in high doses (10+mg) have caused virilization in women.(4) However, the women I know who have actually used this drug haven’t reported anything like that. In fact, most women I know who have used it experienced much more positive effects from than men, as very little of this compound is actually needed to produce results in women.

The popularity of this drug in the East German’s gold medal winning cycles probably contributes quite a bit to it’s popularity, and unfortunately to its price also. Typically, although this drug is easily found on the black market, it’s also in relatively high demand, and that keeps the price stable- and high.]]> https://hypermuscles.com/showthread.php?tid=1216 Mon, 17 Jan 2011 06:16:59 +0000 Cornish_Celt]]> https://hypermuscles.com/showthread.php?tid=1216 Sustanon
Sustanon 250

Pharmaceutical Name: Testosterone (as 30 mg propionate, 60 mg isocaproate, 60 mg as phenylpropionate, 100 mg decanoate)
Chemical structure: 4-androstene-3-one,17beta-ol
Molecular weight of base: 288.429
Molecular weight of ester: 74.0792 (propionic acid, 3 carbons)
Molecular weight of ester: 116.1596 (isocaproic acid, 6 carbons)
Molecular weight of ester: 150.1768 (Propionic acid phenyl ester, 9 carbons)
Molecular weight of ester: 172.2668

Characteristics:
Testosterone is the prime male androgen in the body, and as such still the best possible mass builder in the world. It has a high risk of side-effects because it readily converts to a more androgenic form (DHT) in androgen responsive tissues and forms estrogen quite easily. But these characteristics also provide it with its extreme anabolic tendencies. On the one hand estrogen increases growth hormone output, glucose utilization, improves immunity and upgrades the androgen receptor, while on the other hand a testosterone/DHT combination is extremely potent at activating the androgen receptor and eliciting major strength and size gains. While not always the most visually appealing result, there is no steroid on earth that packs on mass like testosterone does.

Sustanon 250 is a unique blend of 4 different esters of testosterone. The principle purpose of attaching an ester to a steroid is to make it more lipophillic, so that when injected intra-muscularly it can remain in the adipose tissue longer and is released in the blood-stream over time. The longer an ester, the more lipophillic it is. Sustanon 250 contain 1 short, 1 long and 2 medium length esters that are all delivered over time, which gives a quick release, but a durable one as well. You may think that this is a positive thing, and to patients requiring testosterone therapy this probably is, but to a steroid user its really not.

A steroid user will use a long-acting testosterone and inject it once a week. The end of a week is usually the time when a long-acting (7 or 8 carbon) ester has tapered down to its original level and threatens to drop below that level, giving sub-par amounts of testosterone beyond that point (eventhough the compound stays somewhat active for 3-4 weeks). With sustanon, that equal amount is divided much differently. Imagine a hypothetical situation where one take either 270 mg of a an ester that lasts 6 days, or 270 mg of a blend of different esters, 90 mg each, that release over respectively 2, 4 and 6 days, analog to sustanon. With the first one, an even amount of testosterone is released on each day. With the second one the entire first ester, half the second ester and 1/3rd of the last ester is released within the first two days. The result here is clear : the first two days one gets 165 mg, the next two one gets 75 mg and the last 2 days one gets a mere 30 mg. The levels peak much sooner, and drop off sooner, leaving you with less than adequate androgen levels as the week draws to a close.

So for use as one would use another long-acting testosterone, I find sustanon to be poor value. The price is roughly the same so I really don't see the affinity people seem to have for it. Respectively cypionate and enanthate are much better choices. I can understand the need for a fast-acting component to front-load and kick-start gains, but even then, testoviron (200 mg testosterone enanthate and 50 mg testosterone propionate) is a much better choice. Speaking of front-loading, for this express purpose sustanon may be very suited. One could probably obtain results faster If one were to use 500 mg of sustanon on day 1, then again 5 days later on day 6 and start a cycle of enanthate/cypionate at 500 mg/week on day 11. That avoids the major crash at the end of the week and makes maximum use of the fast acting esters to saturate the system.

As with all testosterones the rate of side-effects is quite high. Risks of androgenic side-effects (hair loss, prostate hypertrophy, deepening of voice) as well as estrogenic side-effects (gyno, water retention, fat gain) are real, and the use of ancillary drugs such as anti-estrogens will most likely be needed. This is something that I urge all users to take into account. Never start any cycle with testosterone without having at least a lot of Nolvadex and a few amps of HCG on hand. Testosterone is not in any way toxic, and should not give a user any problems apart from a high rate of occurrence of standard steroid side-effects.

Stacking and Use:
Because of its long-acting components, sustanon is mostly used as a form of long-acting testosterone. Much like testoviron, testosterone enanthate and testosterone cypionate. I don't find it to be the best choice for this purpose, but obviously I don't determine the trends among bodybuilders. In such use doses of 500 to 1000 mg per week are used in a single injection, with decent results nonetheless. Perhaps because 3 of its esters are notably shorter than enanthate or cypionate, so more of it is actual testosterone and less ester, eventhough the distribution is uneven. Its best use in my opinion is to start off a cycle with, by injecting twice with 5 days space, and then give it another 5 days before starting an 8-10 week cycle of testoviron, enanthate or cypionate. This should allow for more testosterone to build up and results to come much faster.

Again, because of the two medium-length and the long ester, the compound is not very controllable. So when problems occur, simply discontinuing the product is not an option. One needs to be familiar with anti-estrogenic compounds for one. When signs of gyno appear using 20-40 mg/day of the estrogen antagonist Nolvadex or 100-150 mg/day of its weaker counterpart clomid until a few days after symptoms disappear is advised. The best way to avoid such problems is running proviron or arimidex, aromatase blockers, alongside the product. In most instances I give preference to arimidex, but when concerning the use of testosterone Proviron at 50-100 mg per day may be wiser since it frees up more testosterone.

Of course the simultaneous use of an aromatase blocker will compromise your gains since it literally stops estrogen from being made. Androgenic problems can be reduced to some extent by the use of finasteride, which will stop the conversion of testosterone to its more androgenic component DHT. This may alleviate aggravated hair loss and prostate problems somewhat. Again, the blocking of such a conversion may decrease the gains made and will in any case heighten the risk for estrogenic side-effects, since DHT acts as an anti-estrogen. Proviron is also a form of DHT, so people worried about androgenic side-effects should then naturally opt for arimidex over proviron when they choose an aromatase blocker as well.

Sustanon stacks well with any compound. Usually testosterone is always the stronger compound in the stack, so whenever you stack something alongside its usually because the drug has certain characteristics. Usually this means it will be a milder drug that will allow the user a milder cycle with lower occurrence of side-effects than simply using more testosterone, without having to give up all of the potential gains. Deca-Durabolin, Equipoise and Primobolan are some of the more fitting compounds for this purpose. But naturally the king of all mass-builders stacks well with almost anything.]]> Sustanon
Sustanon 250

Pharmaceutical Name: Testosterone (as 30 mg propionate, 60 mg isocaproate, 60 mg as phenylpropionate, 100 mg decanoate)
Chemical structure: 4-androstene-3-one,17beta-ol
Molecular weight of base: 288.429
Molecular weight of ester: 74.0792 (propionic acid, 3 carbons)
Molecular weight of ester: 116.1596 (isocaproic acid, 6 carbons)
Molecular weight of ester: 150.1768 (Propionic acid phenyl ester, 9 carbons)
Molecular weight of ester: 172.2668

Characteristics:
Testosterone is the prime male androgen in the body, and as such still the best possible mass builder in the world. It has a high risk of side-effects because it readily converts to a more androgenic form (DHT) in androgen responsive tissues and forms estrogen quite easily. But these characteristics also provide it with its extreme anabolic tendencies. On the one hand estrogen increases growth hormone output, glucose utilization, improves immunity and upgrades the androgen receptor, while on the other hand a testosterone/DHT combination is extremely potent at activating the androgen receptor and eliciting major strength and size gains. While not always the most visually appealing result, there is no steroid on earth that packs on mass like testosterone does.

Sustanon 250 is a unique blend of 4 different esters of testosterone. The principle purpose of attaching an ester to a steroid is to make it more lipophillic, so that when injected intra-muscularly it can remain in the adipose tissue longer and is released in the blood-stream over time. The longer an ester, the more lipophillic it is. Sustanon 250 contain 1 short, 1 long and 2 medium length esters that are all delivered over time, which gives a quick release, but a durable one as well. You may think that this is a positive thing, and to patients requiring testosterone therapy this probably is, but to a steroid user its really not.

A steroid user will use a long-acting testosterone and inject it once a week. The end of a week is usually the time when a long-acting (7 or 8 carbon) ester has tapered down to its original level and threatens to drop below that level, giving sub-par amounts of testosterone beyond that point (eventhough the compound stays somewhat active for 3-4 weeks). With sustanon, that equal amount is divided much differently. Imagine a hypothetical situation where one take either 270 mg of a an ester that lasts 6 days, or 270 mg of a blend of different esters, 90 mg each, that release over respectively 2, 4 and 6 days, analog to sustanon. With the first one, an even amount of testosterone is released on each day. With the second one the entire first ester, half the second ester and 1/3rd of the last ester is released within the first two days. The result here is clear : the first two days one gets 165 mg, the next two one gets 75 mg and the last 2 days one gets a mere 30 mg. The levels peak much sooner, and drop off sooner, leaving you with less than adequate androgen levels as the week draws to a close.

So for use as one would use another long-acting testosterone, I find sustanon to be poor value. The price is roughly the same so I really don't see the affinity people seem to have for it. Respectively cypionate and enanthate are much better choices. I can understand the need for a fast-acting component to front-load and kick-start gains, but even then, testoviron (200 mg testosterone enanthate and 50 mg testosterone propionate) is a much better choice. Speaking of front-loading, for this express purpose sustanon may be very suited. One could probably obtain results faster If one were to use 500 mg of sustanon on day 1, then again 5 days later on day 6 and start a cycle of enanthate/cypionate at 500 mg/week on day 11. That avoids the major crash at the end of the week and makes maximum use of the fast acting esters to saturate the system.

As with all testosterones the rate of side-effects is quite high. Risks of androgenic side-effects (hair loss, prostate hypertrophy, deepening of voice) as well as estrogenic side-effects (gyno, water retention, fat gain) are real, and the use of ancillary drugs such as anti-estrogens will most likely be needed. This is something that I urge all users to take into account. Never start any cycle with testosterone without having at least a lot of Nolvadex and a few amps of HCG on hand. Testosterone is not in any way toxic, and should not give a user any problems apart from a high rate of occurrence of standard steroid side-effects.

Stacking and Use:
Because of its long-acting components, sustanon is mostly used as a form of long-acting testosterone. Much like testoviron, testosterone enanthate and testosterone cypionate. I don't find it to be the best choice for this purpose, but obviously I don't determine the trends among bodybuilders. In such use doses of 500 to 1000 mg per week are used in a single injection, with decent results nonetheless. Perhaps because 3 of its esters are notably shorter than enanthate or cypionate, so more of it is actual testosterone and less ester, eventhough the distribution is uneven. Its best use in my opinion is to start off a cycle with, by injecting twice with 5 days space, and then give it another 5 days before starting an 8-10 week cycle of testoviron, enanthate or cypionate. This should allow for more testosterone to build up and results to come much faster.

Again, because of the two medium-length and the long ester, the compound is not very controllable. So when problems occur, simply discontinuing the product is not an option. One needs to be familiar with anti-estrogenic compounds for one. When signs of gyno appear using 20-40 mg/day of the estrogen antagonist Nolvadex or 100-150 mg/day of its weaker counterpart clomid until a few days after symptoms disappear is advised. The best way to avoid such problems is running proviron or arimidex, aromatase blockers, alongside the product. In most instances I give preference to arimidex, but when concerning the use of testosterone Proviron at 50-100 mg per day may be wiser since it frees up more testosterone.

Of course the simultaneous use of an aromatase blocker will compromise your gains since it literally stops estrogen from being made. Androgenic problems can be reduced to some extent by the use of finasteride, which will stop the conversion of testosterone to its more androgenic component DHT. This may alleviate aggravated hair loss and prostate problems somewhat. Again, the blocking of such a conversion may decrease the gains made and will in any case heighten the risk for estrogenic side-effects, since DHT acts as an anti-estrogen. Proviron is also a form of DHT, so people worried about androgenic side-effects should then naturally opt for arimidex over proviron when they choose an aromatase blocker as well.

Sustanon stacks well with any compound. Usually testosterone is always the stronger compound in the stack, so whenever you stack something alongside its usually because the drug has certain characteristics. Usually this means it will be a milder drug that will allow the user a milder cycle with lower occurrence of side-effects than simply using more testosterone, without having to give up all of the potential gains. Deca-Durabolin, Equipoise and Primobolan are some of the more fitting compounds for this purpose. But naturally the king of all mass-builders stacks well with almost anything.]]> https://hypermuscles.com/showthread.php?tid=1215 Mon, 17 Jan 2011 06:15:23 +0000 Cornish_Celt]]> https://hypermuscles.com/showthread.php?tid=1215 Cheque Drops

Pharmaceutical Name: Mibolerone
Chemical structure: 7-alpha, 17-alpha-dimethyl-19Nor-androst-4-en-3-one,17b-ol
Molecular weight of base: 302.4558

Effective dose: A few drops per day, taken sublingually
Average Street-price: Will vary according to availability, hard to come by
Available Doses: Sublingual drops

Brands & Products:

Characteristics:This is without a doubt THE most powerful steroid that was ever commercially marketed. Its androgenic potency is slightly less than that of methyltrienolone, but it can still aromatize, adding the benefits of estrogen as well. Unfortunately the only product it was ever marketed as never fully exploited the potential of this drug. It was delivered in microgram amounts in liquid droppers, the intent being to add a few drops to the food of female dogs in heat to keep them under control. Human athletes used a few drops under the tongue before a sporting event or training to increase their aggression levels, but noted little or no anabolic effect from this drug because it was so lowly dosed. Not that there was much room for high doses, because even in these low amounts using it longer than 2 or 3 weeks on end seemed to seriously compromise your liver. Just to demonstrate quite how toxic the compound mibolerone was to humans.
If it was free and safe to use orally, just 5 mg per day would probably give you more anabolic effect than a high-dose stack of several of the strongest products out there. It wasn't that far in potency from methyltrienolone. It possessed the same androgenic binding of trenbolone, even more so because its affinity for binding structures was even more reduced due to its 17-alpha-alkylation. But unlike methyltrienolone, it still allowed for aromatization to testosterone, enhanced by the progestagenic effect that all 19nor compounds seem to possess, which only further enhanced the extreme anabolic effect of mibolerone. Unfortunately because of its 17-alpha-alkylation it also rivaled methyltrienolone (metribolone) in liver toxicity, making it completely unsafe to even use 5 mg a day without killing yourself short term. A much better choice in that regard would have been trestolone (MENT), which is the same as Mibolerone but doesn't possess the toxic 17-alpha-methyl group. Sadly enough, MENT was never commercially marketed despite its well documented use as a male contraceptive (same for Mibolerone as well by the way).
But bodybuilders and other athletes had to make do with low-dosed cheque drops to increase activity. Nonetheless they enjoyed a great popularity. Mostly owed to the late Steroid guru Dan Duchaine. This was one of his many obscure (and usually dangerous) discoveries. The same person that discovered DNP, and extremely hazardous and powerful fatburner. Oddly enough cheque drops were more popular outside of bodybuilding. Boxers, football players and martial artists who fought full contact particularly had a fondness of this product and used it to enhance aggression prior to an important match with great success. It wasn't seldom that when a particularly aggressive incident occurred in boxing, that it was rumoured Mibolerone was the real culprit.
But even that didn't last, cheque drops have all but disappeared and I have yet to come across a legit one, or even an empty packaging from a legit one a long time ago. Which would illustrate what a dinosaur cheque drops have become in such a short time. But for those who really look around, they are still out there and I believe in some countries still used in veterinary medicine. So if you want it bad enough, but like I said, its impossible to use it to its full capacity, so its probably a waste to pursue anyway.

Stacking and Use:
Because its extremely toxic in higher doses and cannot be used longer than 2 weeks on end, there really isn't much to stack with cheque drops. A user will opt to take but a few drops sublingually (under the tongue) prior to an event for which he requires and increase in energy and aggression. But because here too there is the risk of natural testosterone suppression, cheque drops are best used during a cycle with other anabolic steroids. In this nature it stacks with literally everything however, and is both suited for use during bulking as well as cutting, eventhough it doesn't have a direct influence on either.
Because it's a non-aromatizing steroid that cannot be used longer than two weeks, the post-cycle use of clomid or Nolvadex is not required. Natural test will only partially be suppressed and should bounce back. If as advised you stacked it with a longer cycle of other steroids, its imperative that you still run them because of these other steroids, not so much for the cheque drops. For those prone to hypertension the use of an anti-hypertensive agent like Catapresan would be advised however. No other ancillaries should be required with this agent.]]> Cheque Drops

Pharmaceutical Name: Mibolerone
Chemical structure: 7-alpha, 17-alpha-dimethyl-19Nor-androst-4-en-3-one,17b-ol
Molecular weight of base: 302.4558

Effective dose: A few drops per day, taken sublingually
Average Street-price: Will vary according to availability, hard to come by
Available Doses: Sublingual drops

Brands & Products:

Characteristics:This is without a doubt THE most powerful steroid that was ever commercially marketed. Its androgenic potency is slightly less than that of methyltrienolone, but it can still aromatize, adding the benefits of estrogen as well. Unfortunately the only product it was ever marketed as never fully exploited the potential of this drug. It was delivered in microgram amounts in liquid droppers, the intent being to add a few drops to the food of female dogs in heat to keep them under control. Human athletes used a few drops under the tongue before a sporting event or training to increase their aggression levels, but noted little or no anabolic effect from this drug because it was so lowly dosed. Not that there was much room for high doses, because even in these low amounts using it longer than 2 or 3 weeks on end seemed to seriously compromise your liver. Just to demonstrate quite how toxic the compound mibolerone was to humans.
If it was free and safe to use orally, just 5 mg per day would probably give you more anabolic effect than a high-dose stack of several of the strongest products out there. It wasn't that far in potency from methyltrienolone. It possessed the same androgenic binding of trenbolone, even more so because its affinity for binding structures was even more reduced due to its 17-alpha-alkylation. But unlike methyltrienolone, it still allowed for aromatization to testosterone, enhanced by the progestagenic effect that all 19nor compounds seem to possess, which only further enhanced the extreme anabolic effect of mibolerone. Unfortunately because of its 17-alpha-alkylation it also rivaled methyltrienolone (metribolone) in liver toxicity, making it completely unsafe to even use 5 mg a day without killing yourself short term. A much better choice in that regard would have been trestolone (MENT), which is the same as Mibolerone but doesn't possess the toxic 17-alpha-methyl group. Sadly enough, MENT was never commercially marketed despite its well documented use as a male contraceptive (same for Mibolerone as well by the way).
But bodybuilders and other athletes had to make do with low-dosed cheque drops to increase activity. Nonetheless they enjoyed a great popularity. Mostly owed to the late Steroid guru Dan Duchaine. This was one of his many obscure (and usually dangerous) discoveries. The same person that discovered DNP, and extremely hazardous and powerful fatburner. Oddly enough cheque drops were more popular outside of bodybuilding. Boxers, football players and martial artists who fought full contact particularly had a fondness of this product and used it to enhance aggression prior to an important match with great success. It wasn't seldom that when a particularly aggressive incident occurred in boxing, that it was rumoured Mibolerone was the real culprit.
But even that didn't last, cheque drops have all but disappeared and I have yet to come across a legit one, or even an empty packaging from a legit one a long time ago. Which would illustrate what a dinosaur cheque drops have become in such a short time. But for those who really look around, they are still out there and I believe in some countries still used in veterinary medicine. So if you want it bad enough, but like I said, its impossible to use it to its full capacity, so its probably a waste to pursue anyway.

Stacking and Use:
Because its extremely toxic in higher doses and cannot be used longer than 2 weeks on end, there really isn't much to stack with cheque drops. A user will opt to take but a few drops sublingually (under the tongue) prior to an event for which he requires and increase in energy and aggression. But because here too there is the risk of natural testosterone suppression, cheque drops are best used during a cycle with other anabolic steroids. In this nature it stacks with literally everything however, and is both suited for use during bulking as well as cutting, eventhough it doesn't have a direct influence on either.
Because it's a non-aromatizing steroid that cannot be used longer than two weeks, the post-cycle use of clomid or Nolvadex is not required. Natural test will only partially be suppressed and should bounce back. If as advised you stacked it with a longer cycle of other steroids, its imperative that you still run them because of these other steroids, not so much for the cheque drops. For those prone to hypertension the use of an anti-hypertensive agent like Catapresan would be advised however. No other ancillaries should be required with this agent.]]> https://hypermuscles.com/showthread.php?tid=1214 Mon, 17 Jan 2011 06:13:40 +0000 Cornish_Celt]]> https://hypermuscles.com/showthread.php?tid=1214 Proviron

Pharmaceutical Name: Mesterolone
Chemical structure: 1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one
Molecular weight of base: 304.4716

Characteristics:
Mesterolone is an orally active, 1-methylated DHT. Like Masteron, but then actually delivered in an oral fashion. DHT is the conversion product of testosterone at the 5-alpha-reductase enzyme, the result being a hormone that is 3 to 4 times as androgenic and is structurally incapable of forming estrogen. One would imagine then that mesterolone would be a perfect drug to enhance strength and add small but completely lean gains to the frame. Unfortunately there is a control mechanism for DHT in the human body. When levels get too high, the 3alpha hydroxysteroid dehydrogenase enzyme converts it to a mostly inactive compound known as 3-alpha (5-alpha-androstan-3alpha,17beta-diol), a prohormone if you will. It can equally convert back to DHT by way of the same enzyme when low levels of DHT are detected. But it means that unless one uses ridiculously high amounts, most of what is administered is quite useless at the height of the androgen receptor in muscle tissue and thus mesterolone is not particularly suited, if at all, to promote muscle hypertrophy.

Proviron has four distinct uses in the world of bodybuilding. The first being the result of its structure. It is 5-alpha reduced and not capable of forming estrogen, yet it nonetheless has a much higher affinity for the aromatase enzyme (which converts testosterone to estrogen) than testosterone does. That means in administering it with testosterone or another aromatizable compound, it prevents estrogen build-up because it binds to the aromatase enzyme very strongly, thereby preventing these steroids from interacting with it and forming estrogen. So Mesterolone use has the extreme benefit of reducing estrogenic side-effects and water retention noted with other steroids, and as such still help to provide mostly lean gains. Its also been suggested that it may actually downgrade the actual estrogen receptor making it doubly effective at reducing circulating estrogen levels.

The second use is in enhancing the potency of testosterone. Testosterone in the body at normal physiological levels is mostly inactive. As much as 97 or 98 percent of testosterone in that amount is bound to sex hormone binding globulin (SHBG) and albumin, two proteins. In such a form testosterone is mostly inactive. But as with the aromatase enzyme, DHT has a higher affinity for these proteins than testosterone does, so when administered simultaneously the mesterolone will attach to the SHBG and albumin, leaving larger amounts of free testosterone to mediate anabolic activities such as protein synthesis. Another way in which it helps to increase gains. Its also another part of the equation that makes it ineffective on its own, as binding to these proteins too, would render it a non-issue at the androgen receptor.

Thirdly, mesterolone is added in pre-contest phases to increase a distinct hardness and muscle density. Probably due to its reduction in circulating estrogen, perhaps due to the downregulating of the estrogen receptor in muscle tissue, it decreases the total water build-up of the body giving its user a much leaner look, and a visual effect of possessing "harder" muscles with more cuts and striations. Proviron is often used as a last-minute secret by a lot of bodybuilders and both actors and models have used it time and again to deliver top shape day in day out, when needed. Like the other methylated DHT compound, drostanolone, mesterolone is particularly potent in achieving this feat.

Lastly Proviron is used during a cycle of certain hormones such as nandrolone, with a distinct lack of androgenic nature, or perhaps 5-alpha reduced hormones that don't have the same affinities as DHT does. Such compounds, thinking of trenbolone, nandrolone and such in particular, have been known to decrease libido. Limiting the athlete to perform sexually being the logical result. DHT plays a key role in this process and is therefore administered in conjunction with such steroids to ease or relieve this annoying side-effect. Proviron is also commonly prescribed by doctors to people with low levels of testosterone, or patients with chronic impotence. Its not perceived as a powerful anabolic, but it gets the job done equally well if not better than other anabolic steroids making it a favorite in medical practices due to its lower chance of abuse.

Mesterolone is generally well liked nonetheless as it delivers very few side-effects in men. In high doses it can cause some virilization symptoms in women. But because of the high level of deactivation and pre-destination in the system (albumin, SHBG, 3bHSD, aromatase) quite a lot of it, if not all simply never reaches the androgen receptor where it would cause anabolic effects, but also side-effects. So its relatively safe. Doses between 25 and 250 mg per day are used with no adverse effects. 50 mg per day is usually sufficient to be effective in each of the four cases we mentioned up above, so going higher really isn't necessary. Unlike what some suggest or believe, its not advised that Proviron be used when not used in conjunction with another steroid, as it too is quite suppressive of natural testosterone, leading to all sorts of future complications upon discontinuation. Ranging from loss of libido or erectile dysfunction all the way up to infertility. One would not be aware of such dangers because Proviron fulfills most of the functions of normal levels of testosterone.

Stacking and Use:
Mesterolone is an oral alkylated steroid. If used primarily as an anti-aromatase drug, using it throughout a longer cycle (10-12 weeks) of injectables may elevate liver values a little bit, though much, much less than one would expect with a 17-alpha-alkylated steroid. Eventhough instead of inhibiting gains, mesterolone may actually contribute to gains. So that's a bit of a shame. Its not quite as toxic since its not alkylated in the same fashion, but at the 1 position, which reduces hepatic breakdown, but not like 17-alpha alkylation. The reason for the change of position I assume, is because alkylating at the 17-alpha position has been shown to reduce affinity for sex hormone binding proteins. This would in turn decrease its ability to free testosterone. Nonetheless the delivery rate is quite good. Its taken daily in 50-100 mg doses.

The best thing to stack it with is testosterone of course. Its most easily bound to SHBG and albumin, and deactivated for up to 98%. Since the DHT can compete for these structures with higher affinity it would naturally lead to a higher yield of whatever testosterone product you stacked it with. Since DHT levels are notably higher now there is also more stimulation of the androgen receptor causing more strength gains, and because of its affinity for aromatase the overall estrogen level decreases as well. This has as a result that gains are leaner, and once again the overall testosterone yield is increased as less I converted at the aromatase enzyme.

It's of course used in other stacks with products such as methandrostenolone, boldenone and nandrolone to reduce estrogenic activity and increase muscle hardness. The addition of proviron makes boldenone a dead lock for a cutting stack and for some may even make it possible to use nandrolone while cutting, although the use of Winstrol or a receptor antagonist in conjunction is wishful as well. The benefit of adding it to a nandrolone stack is that it may also help you reduce the decrease in libido suffered from nandrolone, since the latter is mostly deactivated by 5-alpha reductase, an enzyme that makes other hormones more androgenic.

Proviron is an anti-aromatase, so obviously anti-estrogens would be futile and redundant. Blood pressure medication for those prone to hypertension may be wise, as this DHT can increase the blood pressure.]]> Proviron

Pharmaceutical Name: Mesterolone
Chemical structure: 1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one
Molecular weight of base: 304.4716

Characteristics:
Mesterolone is an orally active, 1-methylated DHT. Like Masteron, but then actually delivered in an oral fashion. DHT is the conversion product of testosterone at the 5-alpha-reductase enzyme, the result being a hormone that is 3 to 4 times as androgenic and is structurally incapable of forming estrogen. One would imagine then that mesterolone would be a perfect drug to enhance strength and add small but completely lean gains to the frame. Unfortunately there is a control mechanism for DHT in the human body. When levels get too high, the 3alpha hydroxysteroid dehydrogenase enzyme converts it to a mostly inactive compound known as 3-alpha (5-alpha-androstan-3alpha,17beta-diol), a prohormone if you will. It can equally convert back to DHT by way of the same enzyme when low levels of DHT are detected. But it means that unless one uses ridiculously high amounts, most of what is administered is quite useless at the height of the androgen receptor in muscle tissue and thus mesterolone is not particularly suited, if at all, to promote muscle hypertrophy.

Proviron has four distinct uses in the world of bodybuilding. The first being the result of its structure. It is 5-alpha reduced and not capable of forming estrogen, yet it nonetheless has a much higher affinity for the aromatase enzyme (which converts testosterone to estrogen) than testosterone does. That means in administering it with testosterone or another aromatizable compound, it prevents estrogen build-up because it binds to the aromatase enzyme very strongly, thereby preventing these steroids from interacting with it and forming estrogen. So Mesterolone use has the extreme benefit of reducing estrogenic side-effects and water retention noted with other steroids, and as such still help to provide mostly lean gains. Its also been suggested that it may actually downgrade the actual estrogen receptor making it doubly effective at reducing circulating estrogen levels.

The second use is in enhancing the potency of testosterone. Testosterone in the body at normal physiological levels is mostly inactive. As much as 97 or 98 percent of testosterone in that amount is bound to sex hormone binding globulin (SHBG) and albumin, two proteins. In such a form testosterone is mostly inactive. But as with the aromatase enzyme, DHT has a higher affinity for these proteins than testosterone does, so when administered simultaneously the mesterolone will attach to the SHBG and albumin, leaving larger amounts of free testosterone to mediate anabolic activities such as protein synthesis. Another way in which it helps to increase gains. Its also another part of the equation that makes it ineffective on its own, as binding to these proteins too, would render it a non-issue at the androgen receptor.

Thirdly, mesterolone is added in pre-contest phases to increase a distinct hardness and muscle density. Probably due to its reduction in circulating estrogen, perhaps due to the downregulating of the estrogen receptor in muscle tissue, it decreases the total water build-up of the body giving its user a much leaner look, and a visual effect of possessing "harder" muscles with more cuts and striations. Proviron is often used as a last-minute secret by a lot of bodybuilders and both actors and models have used it time and again to deliver top shape day in day out, when needed. Like the other methylated DHT compound, drostanolone, mesterolone is particularly potent in achieving this feat.

Lastly Proviron is used during a cycle of certain hormones such as nandrolone, with a distinct lack of androgenic nature, or perhaps 5-alpha reduced hormones that don't have the same affinities as DHT does. Such compounds, thinking of trenbolone, nandrolone and such in particular, have been known to decrease libido. Limiting the athlete to perform sexually being the logical result. DHT plays a key role in this process and is therefore administered in conjunction with such steroids to ease or relieve this annoying side-effect. Proviron is also commonly prescribed by doctors to people with low levels of testosterone, or patients with chronic impotence. Its not perceived as a powerful anabolic, but it gets the job done equally well if not better than other anabolic steroids making it a favorite in medical practices due to its lower chance of abuse.

Mesterolone is generally well liked nonetheless as it delivers very few side-effects in men. In high doses it can cause some virilization symptoms in women. But because of the high level of deactivation and pre-destination in the system (albumin, SHBG, 3bHSD, aromatase) quite a lot of it, if not all simply never reaches the androgen receptor where it would cause anabolic effects, but also side-effects. So its relatively safe. Doses between 25 and 250 mg per day are used with no adverse effects. 50 mg per day is usually sufficient to be effective in each of the four cases we mentioned up above, so going higher really isn't necessary. Unlike what some suggest or believe, its not advised that Proviron be used when not used in conjunction with another steroid, as it too is quite suppressive of natural testosterone, leading to all sorts of future complications upon discontinuation. Ranging from loss of libido or erectile dysfunction all the way up to infertility. One would not be aware of such dangers because Proviron fulfills most of the functions of normal levels of testosterone.

Stacking and Use:
Mesterolone is an oral alkylated steroid. If used primarily as an anti-aromatase drug, using it throughout a longer cycle (10-12 weeks) of injectables may elevate liver values a little bit, though much, much less than one would expect with a 17-alpha-alkylated steroid. Eventhough instead of inhibiting gains, mesterolone may actually contribute to gains. So that's a bit of a shame. Its not quite as toxic since its not alkylated in the same fashion, but at the 1 position, which reduces hepatic breakdown, but not like 17-alpha alkylation. The reason for the change of position I assume, is because alkylating at the 17-alpha position has been shown to reduce affinity for sex hormone binding proteins. This would in turn decrease its ability to free testosterone. Nonetheless the delivery rate is quite good. Its taken daily in 50-100 mg doses.

The best thing to stack it with is testosterone of course. Its most easily bound to SHBG and albumin, and deactivated for up to 98%. Since the DHT can compete for these structures with higher affinity it would naturally lead to a higher yield of whatever testosterone product you stacked it with. Since DHT levels are notably higher now there is also more stimulation of the androgen receptor causing more strength gains, and because of its affinity for aromatase the overall estrogen level decreases as well. This has as a result that gains are leaner, and once again the overall testosterone yield is increased as less I converted at the aromatase enzyme.

It's of course used in other stacks with products such as methandrostenolone, boldenone and nandrolone to reduce estrogenic activity and increase muscle hardness. The addition of proviron makes boldenone a dead lock for a cutting stack and for some may even make it possible to use nandrolone while cutting, although the use of Winstrol or a receptor antagonist in conjunction is wishful as well. The benefit of adding it to a nandrolone stack is that it may also help you reduce the decrease in libido suffered from nandrolone, since the latter is mostly deactivated by 5-alpha reductase, an enzyme that makes other hormones more androgenic.

Proviron is an anti-aromatase, so obviously anti-estrogens would be futile and redundant. Blood pressure medication for those prone to hypertension may be wise, as this DHT can increase the blood pressure.]]> https://hypermuscles.com/showthread.php?tid=1213 Mon, 17 Jan 2011 06:11:40 +0000 Cornish_Celt]]> https://hypermuscles.com/showthread.php?tid=1213 Winstrol / Stromba

Pharmaceutical Name: Stanozolol
Chemical structure: 17 alpha-methyl-5alpha- androstano [3,2-c]pyrazol-17 beta-ol
Molecular weight of base: 344.5392

Characteristics:
TThis is another one of the popular ones. Next to Deca and D-bol the third most abused substance among athletes is stanozolol, as documented by the many positive drug tests. Among them the case sprinter Ben Johnson, who was stripped of his Gold Medal in the 100 meter dash in the 1988 Olympics. But since then the number of positives has grown exponentially. In bodybuilding Shawn Ray's positive in the 1990 Arnold Schwarzenegger Classic (a brief stint the IFBB had with drug testing). Ray was the winner of that event, but Canadion pro Nimrod King was also shown to have stanazolol metabolites in his urine.

That short paragraph to illustrate what sort of an impact it has made on the world of sports. Stanozolol is commonly referred to as Winny, after its trade name as marketed by Winthrop : Winstrol. In Europe this may be a bit confusing as the most available form there is called Stromba. Winny comes in two forms, an injectable form and an oral form. Both are equally popular and both are to be used daily. The injections are the same compound as the orals, which is methylated. Due to this feat it can't be esterified for time-release. So its not quite suited for weekly injections although this is claimed on the package insert of the veterinary form of Winny. Another thing that would further add to the difficulty of time-release is that it is delivered in an aqueous solution. That would not exactly facilitate the entry into adipose tissue, needed for the esterification and storage of the substrate in the body.

The injectable version often gives more results. In similar doses there is still more breakdown upon first pass in the liver, making it difficult to get an equal amount absorbed. And on top of that it has to be mentioned that most people simply don't take an equal amount. Too many pills, lesser availability, higher cost. Many factors play a role in that. But of course an oral is to be preferred over daily injections as that gives the necessary complications as well. Think of abscesses and lumps, the searching for new injection sites due to pain and so on. Some have solved this problem by simply drinking the Winny injections. It's the same substance, also methylated to withstand the liver, the availability and price are better and its contained in water. So there really aren't many objections to this.

Of course because they are the same substance, regardless of the method of use, its not advised to use Winny for long periods of time. Slightly less hepatoxic than most 17-alpha alkylated substrates, so it can be used a bit longer, as long as 8 weeks, but longer than that is not wise. Elevation of liver values is quite common.

The specificity of Winny however, lies in how it counteracts estrogenic side-effects such as gyno and excess water retention. First of all it's a 5-alpha reduced substrate. 5-alpha reduction breaks the double bond between positions 4 and 5, which is required for conversion to estrogen via aromatase, the primary enzyme for the manufacture of estrogen in males. Because some of these compounds nonetheless show some affinity for aromatase they may have some use in blocking estrogen from other steroids they are stacked with. Wether or not Winny acts in this way is not entirely sure. What has been a popular point of discussion with stanozolol is its suggested anti-progestagenic effects. The theory goes that Winny can bind and compete for a position at the progesterone receptor much like Clomid of Nolvadex would at the estrogen receptor, thereby inhibiting progestagenic effects. Now, progesterone can aggravate estrogenic side-effects by agonizing estrogen and it does play a role in gyno.

We also discussed that certain steroids may indeed stimulate and act at the height of the progesterone receptor including nandrolone and Norethandrolone. These hormones are also altered by it inducing a decrease in libido and a sense of lethargy and such, and eventhough they aromatize in lesser rates than some other steroids, they show an equal capability to cause estrogenic side-effects, particularly when stacked with other aromatizable compounds. Now there is evidence that Winny does indeed bind to the progesterone receptor1 and its users do not indicate the normal characteristics of progesterone stimulation, which bodes well for these anti-progestagenic properties. There is also some clinical data that it does aid in symptoms that require progesterone suppression2. Much in the way danazol was also successfully used. The one thing we shouldn't lose sight of however is in what rate it binds to the progesterone reception. There is no data on this. For all we know it couldn't bind strong enough to compete with nandrolone or norethandrolone. So its not wise to state that Winny is an anti-progestagin per se, but it does make Winny a good match for these products in stacks in any case.

Strong gains are never really made while using stanozolol (it's a weak androgen since it has no 3-keto group needed for androgen binding), but decent and fairly easy to maintain gains are possible. Its limited time of use however makes most experienced users opt for other steroids in that regard. Winny, in bodybuilding circles at least, is used mostly during cutting cycles to maintain mass. Winstrol, like a DHT compound also gives a distinct increase in muscle hardness and striations in people with a low body-fat percentage. This lends further credence that it too may be a an anti-estrogen. But most likely it has more to do with the overall lower levels of circulating estrogen. Winny is also quite effective at promoting strength because it binds very well at the androgen receptor. Short term stanozolol use can promote drastic strength, a feat often employed early in a bulking cycle (although d-bol would be more suited in that case) or late in a cutting cycle to prevent a decrease in performance. This combined with the red blood cell count-stimulating properties of its androgen affinity make it popular among track athletes as well in order to beget better results. As many, including Ben Johnson, did not take into account it can be detected for quite some time after last use so its not advisable for drug tested athletes. Many have assumed otherwise due to the short half-life, but apparently some inactive metabolites are easily esterified, so they can be found up to 5 months after the last injection.

Winny is mostly quite well-tolerated in men. Cramps, headaches, elevated blood pressure and cholesterol levels and liver damage are noted, but on a not so-frequent basis. Standard virilization symptoms associated with the stimulating of the androgen receptor, however, are a problem. Acne, prostate hypertrophy and an aggravation of male pattern baldness can occur, so use by women has to be discouraged.

Due to the frequent rate of injections, users generally have to go spotting for different sites of injection on the body. Calves, shoulders, arms and such. When doing so they noted a localized increase in mass which has given root to the myth that Winny can add muscle where it is injected. What I'm about to say goes for all compounds known to date : Steroids do not increase mass locally. The observance is noted because the injection breaks the fascia around the muscle, which possibly gives a muscle a little more room to grow. This is mostly temporary, and in the best cases very limited. Multiple injections would not increase the size in comparison. When the fascia heals, if it heals, it can lead to something called compartments syndrome, where a nerve is pinched between a muscle and its fascia. Leading to numbness quite often and in some cases to a paralysis of everything that nerve controls. This is not a frequent occurrence. This is rare, but my point was documenting that localized growth spurred by an injection is a myth.

A last note about injectable Winny is : shake before use. Its called an aqueous solution, but the Winny being a steroid is not particularly polar, meaning it doesn't dissolve in the water. When the stuff sits, it will accumulate at the bottom of the vial. A good way to recognize the real stuff as well. So shake before you draw it into a syringe or mix it before you drink it, and perhaps even stir it again once in the syringe prior to injection.]]> Winstrol / Stromba

Pharmaceutical Name: Stanozolol
Chemical structure: 17 alpha-methyl-5alpha- androstano [3,2-c]pyrazol-17 beta-ol
Molecular weight of base: 344.5392

Characteristics:
TThis is another one of the popular ones. Next to Deca and D-bol the third most abused substance among athletes is stanozolol, as documented by the many positive drug tests. Among them the case sprinter Ben Johnson, who was stripped of his Gold Medal in the 100 meter dash in the 1988 Olympics. But since then the number of positives has grown exponentially. In bodybuilding Shawn Ray's positive in the 1990 Arnold Schwarzenegger Classic (a brief stint the IFBB had with drug testing). Ray was the winner of that event, but Canadion pro Nimrod King was also shown to have stanazolol metabolites in his urine.

That short paragraph to illustrate what sort of an impact it has made on the world of sports. Stanozolol is commonly referred to as Winny, after its trade name as marketed by Winthrop : Winstrol. In Europe this may be a bit confusing as the most available form there is called Stromba. Winny comes in two forms, an injectable form and an oral form. Both are equally popular and both are to be used daily. The injections are the same compound as the orals, which is methylated. Due to this feat it can't be esterified for time-release. So its not quite suited for weekly injections although this is claimed on the package insert of the veterinary form of Winny. Another thing that would further add to the difficulty of time-release is that it is delivered in an aqueous solution. That would not exactly facilitate the entry into adipose tissue, needed for the esterification and storage of the substrate in the body.

The injectable version often gives more results. In similar doses there is still more breakdown upon first pass in the liver, making it difficult to get an equal amount absorbed. And on top of that it has to be mentioned that most people simply don't take an equal amount. Too many pills, lesser availability, higher cost. Many factors play a role in that. But of course an oral is to be preferred over daily injections as that gives the necessary complications as well. Think of abscesses and lumps, the searching for new injection sites due to pain and so on. Some have solved this problem by simply drinking the Winny injections. It's the same substance, also methylated to withstand the liver, the availability and price are better and its contained in water. So there really aren't many objections to this.

Of course because they are the same substance, regardless of the method of use, its not advised to use Winny for long periods of time. Slightly less hepatoxic than most 17-alpha alkylated substrates, so it can be used a bit longer, as long as 8 weeks, but longer than that is not wise. Elevation of liver values is quite common.

The specificity of Winny however, lies in how it counteracts estrogenic side-effects such as gyno and excess water retention. First of all it's a 5-alpha reduced substrate. 5-alpha reduction breaks the double bond between positions 4 and 5, which is required for conversion to estrogen via aromatase, the primary enzyme for the manufacture of estrogen in males. Because some of these compounds nonetheless show some affinity for aromatase they may have some use in blocking estrogen from other steroids they are stacked with. Wether or not Winny acts in this way is not entirely sure. What has been a popular point of discussion with stanozolol is its suggested anti-progestagenic effects. The theory goes that Winny can bind and compete for a position at the progesterone receptor much like Clomid of Nolvadex would at the estrogen receptor, thereby inhibiting progestagenic effects. Now, progesterone can aggravate estrogenic side-effects by agonizing estrogen and it does play a role in gyno.

We also discussed that certain steroids may indeed stimulate and act at the height of the progesterone receptor including nandrolone and Norethandrolone. These hormones are also altered by it inducing a decrease in libido and a sense of lethargy and such, and eventhough they aromatize in lesser rates than some other steroids, they show an equal capability to cause estrogenic side-effects, particularly when stacked with other aromatizable compounds. Now there is evidence that Winny does indeed bind to the progesterone receptor1 and its users do not indicate the normal characteristics of progesterone stimulation, which bodes well for these anti-progestagenic properties. There is also some clinical data that it does aid in symptoms that require progesterone suppression2. Much in the way danazol was also successfully used. The one thing we shouldn't lose sight of however is in what rate it binds to the progesterone reception. There is no data on this. For all we know it couldn't bind strong enough to compete with nandrolone or norethandrolone. So its not wise to state that Winny is an anti-progestagin per se, but it does make Winny a good match for these products in stacks in any case.

Strong gains are never really made while using stanozolol (it's a weak androgen since it has no 3-keto group needed for androgen binding), but decent and fairly easy to maintain gains are possible. Its limited time of use however makes most experienced users opt for other steroids in that regard. Winny, in bodybuilding circles at least, is used mostly during cutting cycles to maintain mass. Winstrol, like a DHT compound also gives a distinct increase in muscle hardness and striations in people with a low body-fat percentage. This lends further credence that it too may be a an anti-estrogen. But most likely it has more to do with the overall lower levels of circulating estrogen. Winny is also quite effective at promoting strength because it binds very well at the androgen receptor. Short term stanozolol use can promote drastic strength, a feat often employed early in a bulking cycle (although d-bol would be more suited in that case) or late in a cutting cycle to prevent a decrease in performance. This combined with the red blood cell count-stimulating properties of its androgen affinity make it popular among track athletes as well in order to beget better results. As many, including Ben Johnson, did not take into account it can be detected for quite some time after last use so its not advisable for drug tested athletes. Many have assumed otherwise due to the short half-life, but apparently some inactive metabolites are easily esterified, so they can be found up to 5 months after the last injection.

Winny is mostly quite well-tolerated in men. Cramps, headaches, elevated blood pressure and cholesterol levels and liver damage are noted, but on a not so-frequent basis. Standard virilization symptoms associated with the stimulating of the androgen receptor, however, are a problem. Acne, prostate hypertrophy and an aggravation of male pattern baldness can occur, so use by women has to be discouraged.

Due to the frequent rate of injections, users generally have to go spotting for different sites of injection on the body. Calves, shoulders, arms and such. When doing so they noted a localized increase in mass which has given root to the myth that Winny can add muscle where it is injected. What I'm about to say goes for all compounds known to date : Steroids do not increase mass locally. The observance is noted because the injection breaks the fascia around the muscle, which possibly gives a muscle a little more room to grow. This is mostly temporary, and in the best cases very limited. Multiple injections would not increase the size in comparison. When the fascia heals, if it heals, it can lead to something called compartments syndrome, where a nerve is pinched between a muscle and its fascia. Leading to numbness quite often and in some cases to a paralysis of everything that nerve controls. This is not a frequent occurrence. This is rare, but my point was documenting that localized growth spurred by an injection is a myth.

A last note about injectable Winny is : shake before use. Its called an aqueous solution, but the Winny being a steroid is not particularly polar, meaning it doesn't dissolve in the water. When the stuff sits, it will accumulate at the bottom of the vial. A good way to recognize the real stuff as well. So shake before you draw it into a syringe or mix it before you drink it, and perhaps even stir it again once in the syringe prior to injection.]]> https://hypermuscles.com/showthread.php?tid=1212 Mon, 17 Jan 2011 06:10:12 +0000 Cornish_Celt]]> https://hypermuscles.com/showthread.php?tid=1212 Testosterone Enanthate

Pharmaceutical Name: Testosterone (as Enanthate)
Chemical structure: 4-androstene-3-one,17beta-ol
Molecular weight of base: 288.429
Molecular weight of ester: 130.1864 (enanthoic acid, 7 carbons)

Characteristics:
Testosterone is the prime male androgen in the body, and as such still the best possible mass builder in the world. It has a high risk of side-effects because it readily converts to a more androgenic form (DHT) in androgen responsive tissues and forms estrogen quite easily. But these characteristics also provide it with its extreme anabolic tendencies. On the one hand estrogen increases growth hormone output, glucose utilization, improves immunity and upgrades the androgen receptor, while on the other hand a testosterone/DHT combination is extremely potent at activating the androgen receptor and eliciting major strength and size gains. While not always the most visually appealing result, there is no steroid on earth that packs on mass like testosterone does.

Like testosterone cypionate, enanthate is a single-ester and long-acting form of the base steroid testosterone. To me, its slightly better value for money than the aforementioned because its ester is only 7 instead of 8 carbons in length. Where that doesn't really change much in terms of release and blood concentration for users who inject on a weekly basis, that does mean that less of the weight is ester and more of it is testosterone. When taking an amount of an esterified steroid, that amount in terms of weight is a combination of the ester and the steroid. Naturally the longer the ester is, the more of the weight it takes up. So its safe to state that 500 mg of enanthate contains more testosterone than does 500 mg of cypionate. Not that this slight difference will be noted on a weekly pattern really, but its enough for me to give it a slight edge if given the choice. Although, as stated with cypionate, your choice between enanthate and cypionate is best based on availability. These are a much better choice than sustanon 250 or omnadren, which are blends of different testosterone esters, due to their irregular release. Nonetheless these versions still appear to be more popular with most users for some reason. Before you compare these to shorter esters under the pretense that even more of the weight would be testosterone, for bulking purposes the release pattern and injection pattern of an enanthate or cypionate is more fitting than that of say, a propionate ester. Enanthate and cypionate are very close in those terms, hence the comparison is possible.

A long-acting testosterone ester may be the best for all your mass-building needs, but its not an easy product to use. Because of the extreme length of action (3-4 weeks) one cannot easily solve occurring problems by simply discontinuing the product, as it will continue to act and aggravate side-effects over extended periods of time. In regards to damage control and post-cycle therapy, some familiarity with the use of ancillary drugs is required prior to using a long-acting testosterone product. Nolvadex and Proviron will come in very handy in such cases and post-cycle HCG and clomid or Nolvadex will be required as well to help restore natural testosterone. Frequency of side-effects is probably highest with this type of product.

While most will tell you it's a waste to not use testosterone, as it will take ages longer to build proper mass, these are all points to take into consideration. Testosterone is a product that is heavily used by beginners and veterans alike and justly so. Those who fear they may never understand the proper use of ancillary drugs, may want to suck it up and invest in some propionate or suspension testosterones instead. These are much shorter acting and easier to control, but they do need to be injected once every two days, whereas this type of ester will impart great gains with a single weekly injection. Something to keep in mind.

Stacking and Use:
Testosterone is the most powerful compound there is, so obviously its perfectly fine to use it by itself. With a long-acting ester like Enanthate doses of 500-1000 mg per week are used with very clear results over a 10 week period. If you've ever seen a man swell up with sheer size, then testosterone was the cause of it. But testosterone is nonetheless often stacked. Due to the high occurrence of side-effects, people will usually split up a stack in testosterone and a milder component in order to obtain a less risky cycle, but without having to give up as much of the gains. Primobolan, Equipoise and Deca-Durabolin are the weapons of choice in this matter.

Deca seems to be the most popular, probably because of its extremely mild androgenic nature. But Deca being one of the highest risks for just about every other side-effects, I probably wouldn't advise it. If Deca is used, generally a dose of 200-400 mg is added to 500-750 mg of testosterone per week. Primobolan is sometimes opted for, and can be handy since it doesn't aromatize, which will make the total level of water retention and fat gain a lot less than with more test or with Deca for example. Unfortunately, its mild nature combined with a lack of estrogen make Primobolan a very poor mass builder. Again, doses of 300-400 mg are used. I would actually suggest a higher dose, but with the current prices for Primo I don't think it would be very popular. My personal preference goes out to Equipoise. Androgenically its not that much stronger than Deca because it has next to no affinity for the 5-alpha-reductase enzyme and is only half as androgenic as testosterone. Its twice as strong as Deca, mg for mg, and has a lower occurrence of side-effects. It has some estrogen, but not a whole lot so it actually tends to lean a person out rather than bloat him up as Deca will. It also increases appetite, which promotes gains, and improves aerobic performance, which may be wishful as testosterone normally has an opposite effect.

Of course testosterone Enanthate can be stacked with any number of compounds apart from these, but these make the best match. When stacking with testosterone, one needs to look at what the other compound can bring. Either it has a characteristic that testosterone doesn't have, or its nominally safer. The testosterone will bring all the mass, so adding another steroid to enhance mass alone, is futile. More testosterone is the best remedy for that.

One needs to be familiar with a host of other compounds when using long-acting testosterone esters however. First of all, anti-estrogens. The rate of aromatization of testosterone is quite great, so water retention and fat gain are a fact and gyno is never far off. If problems occur one is best to start on 20 mg of Nolvadex per day and stay on that until problems subside. I wouldn't stay on it for a whole cycle, as it may reduce the gains. In terms of an aromatase blocker, testosterone is one of the few compounds where Proviron may actually be preferred over arimidex. The proviron will not only reduce estrogen and can be used for extended time on a testosterone cycle, it will also bind with great affinity to sex-hormone binding proteins in the blood and will allow for a higher level of free testosterone in the body, thus improving gains. Usually 50-100 mg will suffice, the lower end is preferred for maximal results since estrogen plays a key role in gains, but those more worried about estrogen should opt for a higher dose.

For those worried about androgenic side-effects (hair loss, prostate hypertrophy, deepening of voice), one can utilize the hair loss treatment finasteride. This blocks the 5-alpha-reductase enzyme and stops the conversion of testosterone to the more androgenic compound DHT. I'm not a big fan of this, because DHT reduces estrogenic bloat, increases free levels of testosterone and is a very potent androgen that is 3-4 times stronger than testosterone. Those worried about hair loss however, may want to opt for arimidex as their anti-aromatase, since Proviron is a form of DHT after all.

After a cycle, mainly due to the high aromatization and increased levels of estradiol in the blood after discontinuing, natural testosterone levels will be severely suppressed. This means steps need to be taken to assure the quick return of natural testosterone, or we stand to lose a lot of the gains we made while using testosterone. Since it's a non-toxic, potent mass-builder its mostly used in long 10-12 week cycles. So some testicular shrinkage will have occurred too. Its very important that people see that HCG and Nolvadex/clomid are essential as a post-cycle therapy, and that both are equally important in achieving our goal. HCG injections should be started the last week of the cycle and continued for 3-4 weeks, using 1500-3000 IU every 5-6 days. HCG will act as an alternative to LH and start the endogenous testosterone cycle, thereby increasing testicle size once again. Then about 2 weeks after the last shot of testosterone is given, Nolvadex/Clomid cycle should be started. 40 mg of Nolva or 150 mg of Clomid per day for two weeks, followed by two more weeks with either 20 mg of Nolva or 100 mg of Clomid per day should be adequate. Always remember that HCG is suppressive of natural testosterone itself and should be discontinued at least 2 weeks prior to finishing Nolvadex/Clomid.]]> Testosterone Enanthate

Pharmaceutical Name: Testosterone (as Enanthate)
Chemical structure: 4-androstene-3-one,17beta-ol
Molecular weight of base: 288.429
Molecular weight of ester: 130.1864 (enanthoic acid, 7 carbons)

Characteristics:
Testosterone is the prime male androgen in the body, and as such still the best possible mass builder in the world. It has a high risk of side-effects because it readily converts to a more androgenic form (DHT) in androgen responsive tissues and forms estrogen quite easily. But these characteristics also provide it with its extreme anabolic tendencies. On the one hand estrogen increases growth hormone output, glucose utilization, improves immunity and upgrades the androgen receptor, while on the other hand a testosterone/DHT combination is extremely potent at activating the androgen receptor and eliciting major strength and size gains. While not always the most visually appealing result, there is no steroid on earth that packs on mass like testosterone does.

Like testosterone cypionate, enanthate is a single-ester and long-acting form of the base steroid testosterone. To me, its slightly better value for money than the aforementioned because its ester is only 7 instead of 8 carbons in length. Where that doesn't really change much in terms of release and blood concentration for users who inject on a weekly basis, that does mean that less of the weight is ester and more of it is testosterone. When taking an amount of an esterified steroid, that amount in terms of weight is a combination of the ester and the steroid. Naturally the longer the ester is, the more of the weight it takes up. So its safe to state that 500 mg of enanthate contains more testosterone than does 500 mg of cypionate. Not that this slight difference will be noted on a weekly pattern really, but its enough for me to give it a slight edge if given the choice. Although, as stated with cypionate, your choice between enanthate and cypionate is best based on availability. These are a much better choice than sustanon 250 or omnadren, which are blends of different testosterone esters, due to their irregular release. Nonetheless these versions still appear to be more popular with most users for some reason. Before you compare these to shorter esters under the pretense that even more of the weight would be testosterone, for bulking purposes the release pattern and injection pattern of an enanthate or cypionate is more fitting than that of say, a propionate ester. Enanthate and cypionate are very close in those terms, hence the comparison is possible.

A long-acting testosterone ester may be the best for all your mass-building needs, but its not an easy product to use. Because of the extreme length of action (3-4 weeks) one cannot easily solve occurring problems by simply discontinuing the product, as it will continue to act and aggravate side-effects over extended periods of time. In regards to damage control and post-cycle therapy, some familiarity with the use of ancillary drugs is required prior to using a long-acting testosterone product. Nolvadex and Proviron will come in very handy in such cases and post-cycle HCG and clomid or Nolvadex will be required as well to help restore natural testosterone. Frequency of side-effects is probably highest with this type of product.

While most will tell you it's a waste to not use testosterone, as it will take ages longer to build proper mass, these are all points to take into consideration. Testosterone is a product that is heavily used by beginners and veterans alike and justly so. Those who fear they may never understand the proper use of ancillary drugs, may want to suck it up and invest in some propionate or suspension testosterones instead. These are much shorter acting and easier to control, but they do need to be injected once every two days, whereas this type of ester will impart great gains with a single weekly injection. Something to keep in mind.

Stacking and Use:
Testosterone is the most powerful compound there is, so obviously its perfectly fine to use it by itself. With a long-acting ester like Enanthate doses of 500-1000 mg per week are used with very clear results over a 10 week period. If you've ever seen a man swell up with sheer size, then testosterone was the cause of it. But testosterone is nonetheless often stacked. Due to the high occurrence of side-effects, people will usually split up a stack in testosterone and a milder component in order to obtain a less risky cycle, but without having to give up as much of the gains. Primobolan, Equipoise and Deca-Durabolin are the weapons of choice in this matter.

Deca seems to be the most popular, probably because of its extremely mild androgenic nature. But Deca being one of the highest risks for just about every other side-effects, I probably wouldn't advise it. If Deca is used, generally a dose of 200-400 mg is added to 500-750 mg of testosterone per week. Primobolan is sometimes opted for, and can be handy since it doesn't aromatize, which will make the total level of water retention and fat gain a lot less than with more test or with Deca for example. Unfortunately, its mild nature combined with a lack of estrogen make Primobolan a very poor mass builder. Again, doses of 300-400 mg are used. I would actually suggest a higher dose, but with the current prices for Primo I don't think it would be very popular. My personal preference goes out to Equipoise. Androgenically its not that much stronger than Deca because it has next to no affinity for the 5-alpha-reductase enzyme and is only half as androgenic as testosterone. Its twice as strong as Deca, mg for mg, and has a lower occurrence of side-effects. It has some estrogen, but not a whole lot so it actually tends to lean a person out rather than bloat him up as Deca will. It also increases appetite, which promotes gains, and improves aerobic performance, which may be wishful as testosterone normally has an opposite effect.

Of course testosterone Enanthate can be stacked with any number of compounds apart from these, but these make the best match. When stacking with testosterone, one needs to look at what the other compound can bring. Either it has a characteristic that testosterone doesn't have, or its nominally safer. The testosterone will bring all the mass, so adding another steroid to enhance mass alone, is futile. More testosterone is the best remedy for that.

One needs to be familiar with a host of other compounds when using long-acting testosterone esters however. First of all, anti-estrogens. The rate of aromatization of testosterone is quite great, so water retention and fat gain are a fact and gyno is never far off. If problems occur one is best to start on 20 mg of Nolvadex per day and stay on that until problems subside. I wouldn't stay on it for a whole cycle, as it may reduce the gains. In terms of an aromatase blocker, testosterone is one of the few compounds where Proviron may actually be preferred over arimidex. The proviron will not only reduce estrogen and can be used for extended time on a testosterone cycle, it will also bind with great affinity to sex-hormone binding proteins in the blood and will allow for a higher level of free testosterone in the body, thus improving gains. Usually 50-100 mg will suffice, the lower end is preferred for maximal results since estrogen plays a key role in gains, but those more worried about estrogen should opt for a higher dose.

For those worried about androgenic side-effects (hair loss, prostate hypertrophy, deepening of voice), one can utilize the hair loss treatment finasteride. This blocks the 5-alpha-reductase enzyme and stops the conversion of testosterone to the more androgenic compound DHT. I'm not a big fan of this, because DHT reduces estrogenic bloat, increases free levels of testosterone and is a very potent androgen that is 3-4 times stronger than testosterone. Those worried about hair loss however, may want to opt for arimidex as their anti-aromatase, since Proviron is a form of DHT after all.

After a cycle, mainly due to the high aromatization and increased levels of estradiol in the blood after discontinuing, natural testosterone levels will be severely suppressed. This means steps need to be taken to assure the quick return of natural testosterone, or we stand to lose a lot of the gains we made while using testosterone. Since it's a non-toxic, potent mass-builder its mostly used in long 10-12 week cycles. So some testicular shrinkage will have occurred too. Its very important that people see that HCG and Nolvadex/clomid are essential as a post-cycle therapy, and that both are equally important in achieving our goal. HCG injections should be started the last week of the cycle and continued for 3-4 weeks, using 1500-3000 IU every 5-6 days. HCG will act as an alternative to LH and start the endogenous testosterone cycle, thereby increasing testicle size once again. Then about 2 weeks after the last shot of testosterone is given, Nolvadex/Clomid cycle should be started. 40 mg of Nolva or 150 mg of Clomid per day for two weeks, followed by two more weeks with either 20 mg of Nolva or 100 mg of Clomid per day should be adequate. Always remember that HCG is suppressive of natural testosterone itself and should be discontinued at least 2 weeks prior to finishing Nolvadex/Clomid.]]> https://hypermuscles.com/showthread.php?tid=1211 Mon, 17 Jan 2011 06:08:57 +0000 Cornish_Celt]]> https://hypermuscles.com/showthread.php?tid=1211 Testosterone Cypionate

Pharmaceutical Name: Testosterone (as Cypionate)
Chemical structure: 4-androstene-3-one,17beta-ol
Molecular weight of base: 288.429
Molecular weight of ester: 132.1184 (cypionic acid, 8 carbons)

Characteristics:
Testosterone is the prime male androgen in the body, and as such still the best possible mass builder in the world. It has a high risk of side-effects because it readily converts to a more androgenic form (DHT) in androgen responsive tissues and forms estrogen quite easily. But these characteristics also provide it with its extreme anabolic tendencies. On the one hand estrogen increases growth hormone output, glucose utilization, improves immunity and upgrades the androgen receptor, while on the other hand a testosterone/DHT combination is extremely potent at activating the androgen receptor and eliciting major strength and size gains. While not always the most visually appealing result, there is no steroid on earth that packs on mass like testosterone does.

Testosterone Cypionate is a single-ester, long-acting form of testosterone. Due to the length of its ester (8 carbons) it is stored mostly in the adipose tissue upon intra-musuclar injection, and then slowly but very steadily released over a certain period of time. A peak is noted after 24-48 hours of injection and then a slow decline, reaching a steady point after 12 days and staying there for over 3 weeks time. Of course most users of anabolics will not find adequate benefit in the use of this steady-point dose, so this product is normally injected once a week, making the very lowest dose higher than half the peak dose at any given time. This is roughly the starting blood level as well. A long-acting testosterone ester is a must-have in any mass-building cycle. As such this is a very decent product.

Personally I have more affinity for testosterone enanthate, but few users will note any real difference between the two products, and both remain a better buy than their popular counterpart sustanon 250, which is a poor choice of testosterone in my opinion. It makes sense that a user simply opts for which one is most readily available at the time. They sell for roughly the same price, and are almost equally good. So most North and South-American users will usually opt for the use of a cypionate, as it is more available in those regions, whereas Europeans and Asians will probably prefer the enanthate version.

A long-acting testosterone ester may be the best for all your mass-building needs, but its not an easy product to use. Because of the extreme length of action (3-4 weeks) one cannot easily solve occurring problems by simply discontinuing the product, as it will continue to act and aggravate side-effects over extended periods of time. In regards to damage control and post-cycle therapy, some familiarity with the use of ancillary drugs is required prior to using a long-acting testosterone product. Nolvadex and Proviron will come in very handy in such cases and post-cycle HCG and clomid or Nolvadex will be required as well to help restore natural testosterone. Frequency of side-effects is probably highest with this type of product.

While most will tell you it's a waste to not use testosterone, as it will take ages longer to build proper mass, these are all points to take into consideration. Testosterone is a product that is heavily used by beginners and veterans alike and justly so. Those who fear they may never understand the proper use of ancillary drugs, may want to suck it up and invest in some propionate or suspension testosterones instead. These are much shorter acting and easier to control, but they do need to be injected once every two days, whereas this type of ester will impart great gains with a single weekly injection. Something to keep in mind.

Stacking and Use:
Testosterone is the most powerful compound there is, so obviously its perfectly fine to use it by itself. With a long-acting ester like Cypionate doses of 500-1000 mg per week are used with very clear results over a 10 week period. If you've ever seen a man swell up with sheer size, then testosterone was the cause of it. But testosterone is nonetheless often stacked. Due to the high occurrence of side-effects, people will usually split up a stack in testosterone and a milder component in order to obtain a less risky cycle, but without having to give up as much of the gains. Primobolan, Equipoise and Deca-Durabolin are the weapons of choice in this matter. Deca seems to be the most popular, probably because of its extremely mild androgenic nature. But Deca being one of the highest risks for just about every other side-effects, I probably wouldn't advise it. If Deca is used, generally a dose of 200-400 mg is added to 500-750 mg of testosterone per week.

Primobolan is sometimes opted for, and can be handy since it doesn't aromatize, which will make the total level of water retention and fat gain a lot less than with more test or with Deca for example. Unfortunately, its mild nature combined with a lack of estrogen make Primobolan a very poor mass builder. Again, doses of 300-400 mg are used. I would actually suggest a higher dose, but with the current prices for Primo I don't think it would be very popular. My personal preference goes out to Equipoise. Androgenically its not that much stronger than Deca because it has next to no affinity for the 5-alpha-reductase enzyme and is only half as androgenic as testosterone. Its twice as strong as Deca, mg for mg, and has a lower occurrence of side-effects. It has some estrogen, but not a whole lot so it actually tends to lean a person out rather than bloat him up as Deca will. It also increases appetite, which promotes gains, and improves aerobic performance, which may be wishful as testosterone normally has an opposite effect.

Of course testosterone cypionate can be stacked with any number of compounds apart from these, but these make the best match. When stacking with testosterone, one needs to look at what the other compound can bring. Either it has a characteristic that testosterone doesn't have, or its nominally safer. The testosterone will bring all the mass, so adding another steroid to enhance mass alone, is futile. More testosterone is the best remedy for that.

One needs to be familiar with a host of other compounds when using long-acting testosterone esters however. First of all, anti-estrogens. The rate of aromatization of testosterone is quite great, so water retention and fat gain are a fact and gyno is never far off. If problems occur one is best to start on 20 mg of Nolvadex per day and stay on that until problems subside. I wouldn't stay on it for a whole cycle, as it may reduce the gains. In terms of an aromatase blocker, testosterone is one of the few compounds where Proviron may actually be preferred over arimidex. The proviron will not only reduce estrogen and can be used for extended time on a testosterone cycle, it will also bind with great affinity to sex-hormone binding proteins in the blood and will allow for a higher level of free testosterone in the body, thus improving gains.

Usually 50-100 mg will suffice, the lower end is preferred for maximal results since estrogen plays a key role in gains, but those more worried about estrogen should opt for a higher dose. For those worried about androgenic side-effects (hair loss, prostate hypertrophy, deepening of voice), one can utilize the hair loss treatment finasteride. This blocks the 5-alpha-reductase enzyme and stops the conversion of testosterone to the more androgenic compound DHT. I'm not a big fan of this, because DHT reduces estrogenic bloat, increases free levels of testosterone and is a very potent androgen that is 3-4 times stronger than testosterone. Those worried about hair loss however, may want to opt for arimidex as their anti-aromatase, since Proviron is a form of DHT after all.

After a cycle, mainly due to the high aromatization and increased levels of estradiol in the blood after discontinuing, natural testosterone levels will be severely suppressed. This means steps need to be taken to assure the quick return of natural testosterone, or we stand to lose a lot of the gains we made while using testosterone. Since it's a non-toxic, potent mass-builder its mostly used in long 10-12 week cycles. So some testicular shrinkage will have occurred too. Its very important that people see that HCG and Nolvadex/clomid are essential as a post-cycle therapy, and that both are equally important in achieving our goal. HCG injections should be started the last week of the cycle and continued for 3-4 weeks, using 1500-3000 IU every 5-6 days. HCG will act as an alternative to LH and start the endogenous testosterone cycle, thereby increasing testicle size once again. Then about 2 weeks after the last shot of testosterone is given, Nolvadex/Clomid cycle should be started. 40 mg of Nolva or 150 mg of Clomid per day for two weeks, followed by two more weeks with either 20 mg of Nolva or 100 mg of Clomid per day should be adequate. Always remember that HCG is suppressive of natural testosterone itself and should be discontinued at least 2 weeks prior to finishing Nolvadex/Clomid.]]> Testosterone Cypionate

Pharmaceutical Name: Testosterone (as Cypionate)
Chemical structure: 4-androstene-3-one,17beta-ol
Molecular weight of base: 288.429
Molecular weight of ester: 132.1184 (cypionic acid, 8 carbons)

Characteristics:
Testosterone is the prime male androgen in the body, and as such still the best possible mass builder in the world. It has a high risk of side-effects because it readily converts to a more androgenic form (DHT) in androgen responsive tissues and forms estrogen quite easily. But these characteristics also provide it with its extreme anabolic tendencies. On the one hand estrogen increases growth hormone output, glucose utilization, improves immunity and upgrades the androgen receptor, while on the other hand a testosterone/DHT combination is extremely potent at activating the androgen receptor and eliciting major strength and size gains. While not always the most visually appealing result, there is no steroid on earth that packs on mass like testosterone does.

Testosterone Cypionate is a single-ester, long-acting form of testosterone. Due to the length of its ester (8 carbons) it is stored mostly in the adipose tissue upon intra-musuclar injection, and then slowly but very steadily released over a certain period of time. A peak is noted after 24-48 hours of injection and then a slow decline, reaching a steady point after 12 days and staying there for over 3 weeks time. Of course most users of anabolics will not find adequate benefit in the use of this steady-point dose, so this product is normally injected once a week, making the very lowest dose higher than half the peak dose at any given time. This is roughly the starting blood level as well. A long-acting testosterone ester is a must-have in any mass-building cycle. As such this is a very decent product.

Personally I have more affinity for testosterone enanthate, but few users will note any real difference between the two products, and both remain a better buy than their popular counterpart sustanon 250, which is a poor choice of testosterone in my opinion. It makes sense that a user simply opts for which one is most readily available at the time. They sell for roughly the same price, and are almost equally good. So most North and South-American users will usually opt for the use of a cypionate, as it is more available in those regions, whereas Europeans and Asians will probably prefer the enanthate version.

A long-acting testosterone ester may be the best for all your mass-building needs, but its not an easy product to use. Because of the extreme length of action (3-4 weeks) one cannot easily solve occurring problems by simply discontinuing the product, as it will continue to act and aggravate side-effects over extended periods of time. In regards to damage control and post-cycle therapy, some familiarity with the use of ancillary drugs is required prior to using a long-acting testosterone product. Nolvadex and Proviron will come in very handy in such cases and post-cycle HCG and clomid or Nolvadex will be required as well to help restore natural testosterone. Frequency of side-effects is probably highest with this type of product.

While most will tell you it's a waste to not use testosterone, as it will take ages longer to build proper mass, these are all points to take into consideration. Testosterone is a product that is heavily used by beginners and veterans alike and justly so. Those who fear they may never understand the proper use of ancillary drugs, may want to suck it up and invest in some propionate or suspension testosterones instead. These are much shorter acting and easier to control, but they do need to be injected once every two days, whereas this type of ester will impart great gains with a single weekly injection. Something to keep in mind.

Stacking and Use:
Testosterone is the most powerful compound there is, so obviously its perfectly fine to use it by itself. With a long-acting ester like Cypionate doses of 500-1000 mg per week are used with very clear results over a 10 week period. If you've ever seen a man swell up with sheer size, then testosterone was the cause of it. But testosterone is nonetheless often stacked. Due to the high occurrence of side-effects, people will usually split up a stack in testosterone and a milder component in order to obtain a less risky cycle, but without having to give up as much of the gains. Primobolan, Equipoise and Deca-Durabolin are the weapons of choice in this matter. Deca seems to be the most popular, probably because of its extremely mild androgenic nature. But Deca being one of the highest risks for just about every other side-effects, I probably wouldn't advise it. If Deca is used, generally a dose of 200-400 mg is added to 500-750 mg of testosterone per week.

Primobolan is sometimes opted for, and can be handy since it doesn't aromatize, which will make the total level of water retention and fat gain a lot less than with more test or with Deca for example. Unfortunately, its mild nature combined with a lack of estrogen make Primobolan a very poor mass builder. Again, doses of 300-400 mg are used. I would actually suggest a higher dose, but with the current prices for Primo I don't think it would be very popular. My personal preference goes out to Equipoise. Androgenically its not that much stronger than Deca because it has next to no affinity for the 5-alpha-reductase enzyme and is only half as androgenic as testosterone. Its twice as strong as Deca, mg for mg, and has a lower occurrence of side-effects. It has some estrogen, but not a whole lot so it actually tends to lean a person out rather than bloat him up as Deca will. It also increases appetite, which promotes gains, and improves aerobic performance, which may be wishful as testosterone normally has an opposite effect.

Of course testosterone cypionate can be stacked with any number of compounds apart from these, but these make the best match. When stacking with testosterone, one needs to look at what the other compound can bring. Either it has a characteristic that testosterone doesn't have, or its nominally safer. The testosterone will bring all the mass, so adding another steroid to enhance mass alone, is futile. More testosterone is the best remedy for that.

One needs to be familiar with a host of other compounds when using long-acting testosterone esters however. First of all, anti-estrogens. The rate of aromatization of testosterone is quite great, so water retention and fat gain are a fact and gyno is never far off. If problems occur one is best to start on 20 mg of Nolvadex per day and stay on that until problems subside. I wouldn't stay on it for a whole cycle, as it may reduce the gains. In terms of an aromatase blocker, testosterone is one of the few compounds where Proviron may actually be preferred over arimidex. The proviron will not only reduce estrogen and can be used for extended time on a testosterone cycle, it will also bind with great affinity to sex-hormone binding proteins in the blood and will allow for a higher level of free testosterone in the body, thus improving gains.

Usually 50-100 mg will suffice, the lower end is preferred for maximal results since estrogen plays a key role in gains, but those more worried about estrogen should opt for a higher dose. For those worried about androgenic side-effects (hair loss, prostate hypertrophy, deepening of voice), one can utilize the hair loss treatment finasteride. This blocks the 5-alpha-reductase enzyme and stops the conversion of testosterone to the more androgenic compound DHT. I'm not a big fan of this, because DHT reduces estrogenic bloat, increases free levels of testosterone and is a very potent androgen that is 3-4 times stronger than testosterone. Those worried about hair loss however, may want to opt for arimidex as their anti-aromatase, since Proviron is a form of DHT after all.

After a cycle, mainly due to the high aromatization and increased levels of estradiol in the blood after discontinuing, natural testosterone levels will be severely suppressed. This means steps need to be taken to assure the quick return of natural testosterone, or we stand to lose a lot of the gains we made while using testosterone. Since it's a non-toxic, potent mass-builder its mostly used in long 10-12 week cycles. So some testicular shrinkage will have occurred too. Its very important that people see that HCG and Nolvadex/clomid are essential as a post-cycle therapy, and that both are equally important in achieving our goal. HCG injections should be started the last week of the cycle and continued for 3-4 weeks, using 1500-3000 IU every 5-6 days. HCG will act as an alternative to LH and start the endogenous testosterone cycle, thereby increasing testicle size once again. Then about 2 weeks after the last shot of testosterone is given, Nolvadex/Clomid cycle should be started. 40 mg of Nolva or 150 mg of Clomid per day for two weeks, followed by two more weeks with either 20 mg of Nolva or 100 mg of Clomid per day should be adequate. Always remember that HCG is suppressive of natural testosterone itself and should be discontinued at least 2 weeks prior to finishing Nolvadex/Clomid.]]> https://hypermuscles.com/showthread.php?tid=1210 Mon, 17 Jan 2011 06:07:02 +0000 Cornish_Celt]]> https://hypermuscles.com/showthread.php?tid=1210 Primobolan]

Pharmaceutical Name: Methenolone (orally as acetate, injections as enanthate)
Chemical structure: 17 beta-hydroxy-1-methyl-5 alpha-androst-1-en-3-one
Molecular weight of base: 302.4558
Molecular weight of ester: 60.0524 (acetic acid, 2 carbons)
Molecular weight of ester: 130.1864 (enanthoic acid, 7 carbons)

Characteristics:
Primobolan is a well-known and popular steroid as well. Like nandrolone it's most often used as a base compound for stacking with other steroids. Methenolone however, is a DHT-based steroid (actually, DHB or dihydroboldenone, the 5-alpha reduced of the milder boldenon). Meaning when it interacts with the aromatase enzyme it does not form estrogens at all. That makes it ideal for use when cutting when excess estrogen is best avoided because of its retentive effects on water and fat. Methenolone is mostly only used in such instances, or by people who are very succeptible to estrogenic side-effects, because the anabolic activity of methenolone is slightly lower than that of nandrolone, quite likely BECAUSE it is non-estrogenic.

Because it is a widely available steroid its often used as a replacement for nandrolone or boldenone to those who have no access to Deca-Durabolin or Laurabolin or Equipoise. When stacked with a heavy mass steroid like testosterone and/or methandrostenolone it can deliver almost similar gains. Those seeking to cut will most likely be very pleased stacking it with drostanolone, stanozolol or trenbolone. Women and beginners also stack methenolone WITH nandrolone because this gives a mildly anabolic stack that is generally regarded as one of the safer stacks around in an androgenic perspective. But alas, with the nandrolone, also a very suppressive stack.

Methenolone is available as an injection or as an oral. The injection is naturally regarded as better. Its an enanthate ester which is quite long-acting and only needs to be injected once a week in doses of 300-600 mg. Because it by-passes hepatic breakdown on the first pass, it also has a higher survival rate. The orals are a lot less handy, but often preferred by bodybuilders who are afraid of needles or who are already taking one or more injectable compounds. The tabs are in a short-lived acetate form, meaning that doses of 100-150 mg per day are needed, split over 2 or 3 doses, making the tabs quite inconvenient for use. The reason doses need to be split up, unlike most oral steroids, is because Methenolone is not 17-alpha-alkylated, but 1-methylated for oral bio-availability. This reduces the liver stress, but also the availability, hence the multiple and high doses needed daily.

Like nandrolone, methenolone is very mild on the system. Probably the reason why both are strongly favored as base compounds in stacks. Methenolone has no estrogenic side-effects whatsoever, on account of its structure. Its effects on the cholesterol levels are barely noticeable. In doses of 200 mg or less (injectable) blood pressure is rarely, if at all, altered. As for hepatoxicity, long-term use will of course increase liver values but gradually and only slightly. The injections of course, since they only pass the liver once, have roughly half the liver-toxic effects of the tabs. The low liver-toxicity is accounted for that the bio-availability of methenolone is carried by a 1-methyl-group, which lessens the need for a carrier attachment such as a 17-alpha-akylated group, the main culprit in steroid-related liver afflictions.

The strangest thing however, taking into account that Primo is still a DHT (or rather DHB) derivative, is that it is quite easy on the system androgenically as well. Women use methenolone often, usually the tabs, and find little virilisation symptoms in short term use of methenolone. Long-term use may induce some acne and a deepening of the voice however. Methenolone is also not overly suppressive of the HPT axis (endocrinal axis for the production of natural testosterone). These are both the result of DHB's 1,2-double bond, which, analog to the parent structure boldenone, reduces the androgenic binding by 50% as opposed to DHT.

For athletes who wish to maintain a "natural" status in competition, the tablets are quite well-suited as detection chances for the acetate-form are quite slim. However tests have improved and quite a number of metabolites1 of methenolone can be detected with a simple urine sample. But an English study documented that there is a liability in eating methenolone contaminated meats2, which could provide a possible defense if found out. One could always claim they ate the meat of a chicken or cow injected with methenolone since the test concluded eating such meat does not improve performance, but can deliver positive tests for several methenolone metabolites almost 24 hours after ingestion. That's for those of you seeking a viable defense against a possible methenolone-positive.

Stacking and Use:
Methenolone comes in orals and injectables. The injectables are to be preferred as they can be used for quite some time and only require injecting once a week. The orals are taking every day, or multiple times a day. An oral passes through the liver twice. An injectable only once. The injectable is more effective since less is broken down.

Methenolone is not used all that often by experienced users. It makes a good product as an alternative to Deca or EQ in a cutting stack, because it has similar properties but does not aromatize and does not have progestagenic activity. But those at least slightly versed will prefer boldenone over methenolone as its more potent gram for gram. Its quite mild, so its not as prone to cause your standard side-effects. This too makes it quite popular with beginners. Methenolone was quite popular during the 70's in stacks with Methandrostenolone. Some of the all-time greats of bodybuilding were quite fond of this stack.

The common use is similar to that of Nandrolone. 300-400 mg a week, in conjunction with other steroids mostly. Some attempt to make up for the lack of potency switching from nandrolone or boldenone to methenolone by using higher doses, in the neighbourhood of 600-800 mg a week. At that point I feel it would be cheaper to opt for boldenone at 300-400 mg a week though. Methenolone makes a poor stacking partner in mass stacks as both Deca and EQ provide better results while they are qualitatively similar. There is a slight merit in stacking Methenolone with boldenone, because apart from its 1-methyl group, methenolone is basically DHB, the 5-alpha-reduced form of boldenone. But since boldenone itself has very low affinity for 5-alpha-reduction, it should have a good synergistic effect stacking the two at 300 mg/week each.

There is no use for alternate drugs since it does not aromatize, is quite mild and the gains are fairly easy to maintain, so post-cycle use of clomid or Nolvadex is not warranted.]]> Primobolan]

Pharmaceutical Name: Methenolone (orally as acetate, injections as enanthate)
Chemical structure: 17 beta-hydroxy-1-methyl-5 alpha-androst-1-en-3-one
Molecular weight of base: 302.4558
Molecular weight of ester: 60.0524 (acetic acid, 2 carbons)
Molecular weight of ester: 130.1864 (enanthoic acid, 7 carbons)

Characteristics:
Primobolan is a well-known and popular steroid as well. Like nandrolone it's most often used as a base compound for stacking with other steroids. Methenolone however, is a DHT-based steroid (actually, DHB or dihydroboldenone, the 5-alpha reduced of the milder boldenon). Meaning when it interacts with the aromatase enzyme it does not form estrogens at all. That makes it ideal for use when cutting when excess estrogen is best avoided because of its retentive effects on water and fat. Methenolone is mostly only used in such instances, or by people who are very succeptible to estrogenic side-effects, because the anabolic activity of methenolone is slightly lower than that of nandrolone, quite likely BECAUSE it is non-estrogenic.

Because it is a widely available steroid its often used as a replacement for nandrolone or boldenone to those who have no access to Deca-Durabolin or Laurabolin or Equipoise. When stacked with a heavy mass steroid like testosterone and/or methandrostenolone it can deliver almost similar gains. Those seeking to cut will most likely be very pleased stacking it with drostanolone, stanozolol or trenbolone. Women and beginners also stack methenolone WITH nandrolone because this gives a mildly anabolic stack that is generally regarded as one of the safer stacks around in an androgenic perspective. But alas, with the nandrolone, also a very suppressive stack.

Methenolone is available as an injection or as an oral. The injection is naturally regarded as better. Its an enanthate ester which is quite long-acting and only needs to be injected once a week in doses of 300-600 mg. Because it by-passes hepatic breakdown on the first pass, it also has a higher survival rate. The orals are a lot less handy, but often preferred by bodybuilders who are afraid of needles or who are already taking one or more injectable compounds. The tabs are in a short-lived acetate form, meaning that doses of 100-150 mg per day are needed, split over 2 or 3 doses, making the tabs quite inconvenient for use. The reason doses need to be split up, unlike most oral steroids, is because Methenolone is not 17-alpha-alkylated, but 1-methylated for oral bio-availability. This reduces the liver stress, but also the availability, hence the multiple and high doses needed daily.

Like nandrolone, methenolone is very mild on the system. Probably the reason why both are strongly favored as base compounds in stacks. Methenolone has no estrogenic side-effects whatsoever, on account of its structure. Its effects on the cholesterol levels are barely noticeable. In doses of 200 mg or less (injectable) blood pressure is rarely, if at all, altered. As for hepatoxicity, long-term use will of course increase liver values but gradually and only slightly. The injections of course, since they only pass the liver once, have roughly half the liver-toxic effects of the tabs. The low liver-toxicity is accounted for that the bio-availability of methenolone is carried by a 1-methyl-group, which lessens the need for a carrier attachment such as a 17-alpha-akylated group, the main culprit in steroid-related liver afflictions.

The strangest thing however, taking into account that Primo is still a DHT (or rather DHB) derivative, is that it is quite easy on the system androgenically as well. Women use methenolone often, usually the tabs, and find little virilisation symptoms in short term use of methenolone. Long-term use may induce some acne and a deepening of the voice however. Methenolone is also not overly suppressive of the HPT axis (endocrinal axis for the production of natural testosterone). These are both the result of DHB's 1,2-double bond, which, analog to the parent structure boldenone, reduces the androgenic binding by 50% as opposed to DHT.

For athletes who wish to maintain a "natural" status in competition, the tablets are quite well-suited as detection chances for the acetate-form are quite slim. However tests have improved and quite a number of metabolites1 of methenolone can be detected with a simple urine sample. But an English study documented that there is a liability in eating methenolone contaminated meats2, which could provide a possible defense if found out. One could always claim they ate the meat of a chicken or cow injected with methenolone since the test concluded eating such meat does not improve performance, but can deliver positive tests for several methenolone metabolites almost 24 hours after ingestion. That's for those of you seeking a viable defense against a possible methenolone-positive.

Stacking and Use:
Methenolone comes in orals and injectables. The injectables are to be preferred as they can be used for quite some time and only require injecting once a week. The orals are taking every day, or multiple times a day. An oral passes through the liver twice. An injectable only once. The injectable is more effective since less is broken down.

Methenolone is not used all that often by experienced users. It makes a good product as an alternative to Deca or EQ in a cutting stack, because it has similar properties but does not aromatize and does not have progestagenic activity. But those at least slightly versed will prefer boldenone over methenolone as its more potent gram for gram. Its quite mild, so its not as prone to cause your standard side-effects. This too makes it quite popular with beginners. Methenolone was quite popular during the 70's in stacks with Methandrostenolone. Some of the all-time greats of bodybuilding were quite fond of this stack.

The common use is similar to that of Nandrolone. 300-400 mg a week, in conjunction with other steroids mostly. Some attempt to make up for the lack of potency switching from nandrolone or boldenone to methenolone by using higher doses, in the neighbourhood of 600-800 mg a week. At that point I feel it would be cheaper to opt for boldenone at 300-400 mg a week though. Methenolone makes a poor stacking partner in mass stacks as both Deca and EQ provide better results while they are qualitatively similar. There is a slight merit in stacking Methenolone with boldenone, because apart from its 1-methyl group, methenolone is basically DHB, the 5-alpha-reduced form of boldenone. But since boldenone itself has very low affinity for 5-alpha-reduction, it should have a good synergistic effect stacking the two at 300 mg/week each.

There is no use for alternate drugs since it does not aromatize, is quite mild and the gains are fairly easy to maintain, so post-cycle use of clomid or Nolvadex is not warranted.]]>