As you might expect, men who have a lot of bodyfat also produce more estrogen. Studies show that morbidly obese men have lower testosterone.

Other reasons for obesity-related testosterone depletion include high amounts of leptin, a fat-based protein that blunts the release of luteinizing hormone from the pituitary gland, which in turn blunts testosterone synthesis at the Leydig cells. Overweight men also tend to have obstructive sleep apnea, a temporary cessation of breathing during sleep. The resulting interference with the normal sleep cycle lowers testosterone.

Giving obese men testosterone therapy is problematic because their overactive aromatase converts the testosterone into estrogen. A recent study of 12 severely obese men who were given the anti-aromatase drug letrozole, brand name Femara, for six months showed dramatic beneficial effects.3 After six weeks on the drug—2.5 milligrams taken once a week—the men had lower estrogen levels. Total testosterone levels rose to normal in all the men, while free, or active, testosterone rose to above normal in seven out of the 12 men.

After six months, as estrogen does offer men some health protection, that dose wasn’t completely blocking estrogen except in one man. Femara also boosted FSH, a pituitary hormone associated with fertility, so it did restore the men’s fertility.

Studies of women show that Femara lowers estrogen an average of 78 percent. In men the figure may be higher than 90 percent; it’s known to be 10 to 20 times more potent than Arimidex. Anecdotal reports show that Femara is remarkably efficient at regressing early gyno. Since it has a long half-life, meaning the time it takes to be metabolized in the body, it doesn’t need to be taken every day. That’s good because like Arimidex it’s extremely expensive, about $7 a pill! Taking the drug in large amounts lowers libido, and taking it too long may produce an estrogen rebound, characterized by higher than normal estrogen, which of course would put you right back where you started.

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What a RUSHHHHHHHH!!!!!!!!