The Dopamine Connection
Anti-prolactin drugs work by mimicking the activity of a substance in the brain called dopamine, thereby classifying them as dopamine agonists. Dopamine itself is a neurotransmitter; a chemical messenger between nerve cells in the brain. When levels of this neurotransmitter are normal the body functions properly, but if levels become imbalanced serious problems can develop, such as Parkinson’s or Restless Leg Syndrome.
However, in order for dopamine to have an effect it must first attach to dopamine receptor sites, which are found on the surface of the cell. Once attached, the receptor receives, recognizes, and responds to this chemical signal. Dopamine Agonists works by stimulating these same receptor sites, thereby producing the same effects as dopamine, but you may be wondering, how is this relevant to prolactin?
As one of the predominant regulators of prolactin, dopamine has a direct impact on its production. More specifically, dopamine works to reduce prolactin levels by attaching to D3 receptors, which inhibit the production of prolactin by lactotrophs (lactotrophs are prolactin producing cells located in the pituitary). Acting as a dopamine substitute, dopamine agonists works through the same mechanism, fooling the body into thinking that dopamine levels are high. This shuts down, or reduces the production prolactin, depending on the dosage administered.
Exactly how the steroids trenbolone and nandrolone increase prolactin levels, we can’t be sure, but one thing we do know is that many who use these drugs have experienced dramatic elevations of this hormone—sometimes far above normal levels. This can and often does lead to one or more of the aforementioned side effects. Dopamine agonists works to address the issue directly, shutting down prolactin production at its root.
Cabergoline (Dostinex)
Cabergoline (Caber) will lower both progesterone and will inhibit prolactin/lactation. It’s a dopamine agonist means it wont allow your body to lactate since it will occupy your dopamine receptors which are responsible for lactation. Caber is the best prolactin support when running any 19-Nor since the side effects are minimal – no drowsiness, doesn’t affect sleeping patterns, and in general as far as dosing goes is far more flexible than Pramipexole or Bromo. Also there is no withdrawal when ceasing use of Caber like with Prami.
Caber is a recognized ED med, it reduces downtime (not to be confused with multiple orgasm) so if you need 24 hour recovery between sessions two weeks after taking Caber you will see a significant decrease in downtime you will need 12-16 hours to be ready for the next session, if you need 2 hours you will need 1 hour with Caber.
Also its known for its potential multiple orgasm effect - when you ejaculate you will feel as if you are releasing two or three loads at the same time. This needs some input for the user though its not instant, the more you hold it in the more orgasms you will potentially have in the end.
Common Dose On Cycle: 0.25-.5mg E3D or E3.5D
Common Does To Stop Lactation: 1-1.5mg E3-5D
Pramipexole (Mirapex)
Pramipexole (Prami), like Caber, will decrease progesterone and will inhibit prolactin/lactation. It’s a dopamine agonist, like Caber, so it will occupy dopamine receptors which are responsible for lactation.
Pramipexole (Prami) is a very peculiar drug! You need to taper up really slowly to get to the desired dose and also taper down slowly to avoid the mild withdrawal effect it will cause. Prami is an addictive substance and /r/steroids is hesitant recommending it, as the more you use it the harder it will be to come off it, also you will find you will want to increase the dose to maintain the ed effect. Prami’s ED effect is not as good as Caber. It does reduce downtime like Caber does but that’s about it there is not potential enhancement in your orgasm or your libido contrary to caber. Only advantage of Prami over caber is that if taken at the right time (2-3 hours) before bedtime it can work as good as a Benzo to knock you out to sleep. Which when running Tren is a bonus. If, however, you dose it wrong (unwillingly of course) say 30 minutes – 1 hour before bed time you will find that after 2-3h of sleep you will be wide awake and probably sweating since the dopamine you suppressed 4 hours ago rebounds and you feel as if you just had a hit of coke in your sleep, not a good feeling. Also every time you up the dose it takes some adjusting even if you are used to the substance.
Sleep sides like vivid dreams and waking up mid night can be avoided by taking Prami at the right time so you got to experiment with this (the earlier you take it the better). Make sure you never take Prami in the morning or too early in the evening you are going to feel drained, dizzy, nauseous and like a zombie all you will think its when the time comes to go to sleep.
The worst part with Prami starts when you quit, for the first few days after you quit, you will wake up in your sleep many times as if you were quitting cigarettes or weed even, then you will have the lightest sleep ever as if you were sleeping with your eyes open and the dreams will be negative and intense. Basically you get all the Prami sides you had earlier only they cant be avoided since you don’t take Prami anymore. This will subside completely after 5 – 7 days.
Common Dose On Cycle: taper up from 0.125mg to 0.25mg-0.50mg (the high dose only if you are stacking two 19-Nors or high dose of tren). After you are done with your cycle taper down even slower from 0.50mg to 0.125mg and stay one week on each increment then quit. No matter what you do expect some discomfort the first 3-5 days after you quit.
Dose To Stop Lactation: You would probably need 1-2mg per day to stop lactation, but wouldn’t recommend it, it would take ages to rump up to that dose, if you are already lactating, use Caber worse thing that could happen when jumping to a high dose of caber would be to get a flush face that lasts 12-14h (annoying but much better than puking your guts of for hours).
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