Selective Estrogen Receptor Modulators (SERMs)
After your cycle is complete and the steroid esters start to clear the system, a post cycle therapy (PCT) is done to help get the pituitary glands running again. SERM's work by blocking estrogen going into the pituitary glands, which cause a rise in LH/FSH and testosterone levels, temporarily. This helps give a boost after cycle, and it helps maintain gains.
Keep in mind all 3 SERMs will work in favor of your liver (Agonists) since they are mild Estrogens, like stated earlier Estrogen is good for your liver so adding a SERM will always improve your HDL/LDL. All SERMs don’t lower Estrogen, in fact they will increase your total Estrogen. They also block your Estrogen in the nipple area.
Nolvadex (Tamoxifen)
Agonist: Liver, Uterus (female)
Antagonist: Breast/Nipple
Nolvadex is more suited for PCT purposes rather than Gyno Flair-Ups or Gyno Reversal, as it increases natural Test levels by 60%, but will decrease IGF-1 levels +25%.
Dosage on cycle: 20-40mg ED
Dosage for PCT: See PCT
Raloxifene (Evista)
Agonist: Liver, bone (increases bone density and is a recognized treatment for osteoporosis)
Antagonist: Breast/nipple
Raloxifene doesn’t affect IGF-1 levels whatsoever, also it increases bone density. It is the ideal SERM for Gyno Flair-Ups or Gyno Reversal since its an agonist for your bones, doesn’t affect IGF-1 levels, and is perfectly safe to run with a 19-Nor. Raloxifene shouldn’t be used in PCT since it raises natural test levels by 40% only, 20% less than Nolvadex.
Dosage on cycle: 60mg-120mg ED
Gyno Flare-Up Protocol
If your Estrogen is wildly out of control and you are developing puffy, sore, or itchy nipples, UP your AI dose and start taking your SERM.
Note: If you choose Arimidex as your AI, just be aware the blood levels of Arimidex can drop a bit when used alongside Nolvadex.](/r/steroids/wiki/faq/list#wikiq.3A_can_nolvadex.28tamoxifene.29and_arim idex.28anastrozole.29_be_used_together.3F) To avoid this, you may choose Raloxifene.
Dosing: Pharmaceutical Raloxifene 60mg ED or Pharmaceutical Nolvadex 20mg ED. It usually will subside after a 7-12 days. Continue the SERM for 3 days after the symptoms have subsided before you drop the SERM. It is suggested to use Raloxofine over Nolvadex when possible, due to Nolvadex decreasing IGF-1 as seen above.
Gyno Reversal Protocol
If your Gyno is pubertal, as seen above, this potentially could help, but most likely surgery is your best option. If your Gyno is from AAS use, this has worked for multiple users on our board:
Dosing: Pharmaceutical Raloxifene 120mg ED - split the dose ½ in the AM, ½ in the PM for a month, then 60mg ED - split the dose ½ in the AM, ½ in the PM until you've seen sufficient reduction in size.
Toremifene (Fareston)
[Under Construction]
Clomid
Agonist: Liver
Antagonist: Breast/nipple
Clomiphene is a harsh drug, if you get the visual sides/blurry vision from clomid they stay for life. They are rare, but do happen.
Clomiphene is a mixed agonist/antagonist. This is due to the fact that Clomiphene is composed of two isomers: enclomiphene (trans-clomiphene) and zuclomiphene (cis-clomiphene). Enclomiphene is an Estradiol receptor antagonist. Zuclomiphene is an estradiol receptor agonist. In all likelihood, the net antagonist effect might be due to the composition being 70% trans (enclomiphene) and 30% cis (zuclomiphene). Nolvadex/Raloxifene is more of a strict anti-estrogen, decreases the effect of estrogen in the body, and potentiates the action of clomiphene. This combination came about after 100s of clinical experience.
So Nolvadex/Raloxifene is more of an antagonist, than Clomid is. They are better at blocking the ER than Clomid is. Clomid also seems to exert agonistic effects in parts of the brain that control emotion. That would explain why some turn into women on periods during there experiences with Clomid.
Tamoxifen is also made of slightly more isomers, the cis isomer of tamoxifen (inactive one) trans-tamoxifen and trans-4-OHT isomer.
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