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Cornish_Celt · #1 (**permalink**) 04-09-2019, 07:14 AM

Taken from another forum.

Insulin History and Overview:

When it comes to hormones and supplements that are ustilized for maximum aeffect, one of the most popular kinds in the professional bodybuilding circles as well as medical circles is insulin. It has a tremendous amount of benefits that can help people in so many ways, but despite this fact, there are those that take matters into their own hands and use the likes of insulin to maximize gains and make muscle-related strides that just wouldn’t be possible otherwise.

It should be noted that compared to other sorts of hormones, insulin is extremely powerful. Given that it’s an anabolic, it can create tissue rather easily, but it should be noted that it is used exogenously by those that cannot normally produce it, but when it is used by athletes, it’s strictly for the purpose of building lean tissue. It is a very dangerous hormone when abused, so any use, recreational or otherwise should be strongly cautioned regardless of the circumstances.

Similar to the use of injectable testosterone and other hormones, the first synthesized examples of insulin use were back in the 1920s. Back then, most insulin was extracted from the pancreases of cattle and dogs. One of the major issues, however, was the fact that these samples were often not very pure, making purity control a problem that could have dire consequences. But regardless of purity issues, people were willing to risk infection or death during this time period. Insulin treatment was often the only recourse people with diabetes had, and of course, diabetes without insulin treatment can mean terrible health issues and even death. This is primarily why by the 1970s, when the purity issues with insulin were solved, it was a major milestone for not only insulin but other exogenous treatments in general. Starting in the mid 1970s, synthetic insulin would be introduced to the scene by a company called Ciba. By 1982, the famous Humulin-R synthetic insulin was made, and it was a perfect facsimile for human-made insulin, and it immediately got FDA approval and has been a staple in diabetes treatment ever since.
Insulin Functions and Actions:

Insulin works in a few very easy ways. For one, it works to prevent the metabolic breakdown of glycogen, fat, and protein. Since it’s considered a peptide hormone, it works to regulate and utilize glucose, fatty acids, and amino acids. It is produced by the pancreas and is considered to be a peptide hormone.

When it comes to those that suffer from diabetes, there are three kinds that result in the need for insulin supplementation. It’s important to keep these in mind, because all too often, it’s assumed that diabetes by default means someone needs insulin supplementation from exogenous sources. For those with Type 1 diabetes, these are individuals that have a pancreas that simply can’t produce enough insulin on its own to supply the body with adequate insulin. Another kind of insulin is Type 2 diabetes. This one is frustrating in particular because the body can still produce insulin, and maybe in some cases enough of it, but the receptor sites for the insulin simply don’t work, meaning that it has to be supplemented from an outside source. This means that exogenous, injected insulin is the only way it can be synthesized in the body of an individual with Type 2.

As far as being a peptide hormone, when it’s secreted by the pancreas, insulin works with the liver to stimulate the creation of glycogen and then convert it into glucose. Anything else that isn’t a glucose is inhibited, however, and it is here where the insulin works to really to spread the glucose around in the cells, which will, in turn, lead to muscle growth. Higher levels of insulin are also linked to protein synthesis, which is another incredibly valuable part of the muscle-building process in the body. Insulin being in high concentrations within the body also leads to higher levels of bone density, and it can also lead to higher concentrations of a peptide called IGF-1, which is an acronym for Insuline-like Growth Factor 1. It is incredibly anabolic, and it is structured very similarly to insulin, hence its name.

As far as some additional benefits of high concentrations of insulin, it can also lead to higher levels of luteinizing hormone, and it can even crate more follicle stimulating hormone. With the increased levels of the aforementioned hormones, it can essentially be linked to higher levels of testosterone. This means that despite its relatively unknown reputation as a performance enhance among casuals, there are a tremendous amount of benefits it has as a hormone, and it can definitely increase the performance of those looking to use it effectively.