The beauty about science is, the more you find out, the more you realise you don’t know. And with that in mind, we have an ever-present hunger for researching and developing our own knowledge of how everything and anything on our planet works. With access to more resources than ever before, we’re finding the increasing rise of new findings, and even more so, we’re finding out things today that pretty much cancel out things we USED to think were right.*

One recent study however, caught our eyes, and that is, a study that was published in a recent edition of the Journal Of Applied Physiology. It revolves around creating an*increased anabolic response in the body, using nothing but caffeine and lactic acid.

Caffeine and Lactate Supplements Increase Muscle Mass

The newest research published in the latest*Journal of Applied Physiology*seems to support that metabolic stress can increase muscle growth signaling factors. In the study, researchers examined whether a mixed lactate and caffeine compound could effectively elicit proliferation and differentiation of satellite cells or activate anabolic signals in skeletal muscles. Caffeine is a stimulant. It gives you extra stamina and increases your heart rate, improving blood flow from the heart to the rest of your body. At the cellular level, the major player causing muscle contraction is calcium. Caffeine acts directly on the storage site for calcium in skeletal muscle, an area known as the sarcoplasmic reticulum. When caffeine interacts with the sarcoplasmic reticulum, increased amounts of calcium are pumped into the muscle, thus causing stronger muscle contractions. Lactic acid on the other hand is actually a fuel, not a caustic waste product as once previously thought. Muscles make it deliberately, producing it from glucose, and they burn it to obtain energy. The lactic acid is taken up and used as a fuel by mitochondria, the energy factories in muscle cells. *Researchers wanted to examine how when you combine both caffeine and lactic acid into a supplement how it would affect the anabolic pathways. The researchers hypothesized that, “a lactate-based supplement containing caffeine, an activator of intracellular calcium signals, could elicit proliferation and differentiation of satellite cells, activate anabolic signals in skeletal muscle, and thereby increase muscle mass when combined with low-intensity exercise training.”

When the researchers examined the powerful combination when administered to male rats, they found similar increases in the anabolic signaling pathways. In an*in vivo study, male rats were assigned to the control, exercise and lactate and caffeine supplementation groups. Lactate and caffeine was orally administered daily. The lactate and caffeine exercise group and exercise only groups were exercised on a treadmill, running for 30 minutes at low intensity every other day for 4 weeks.*The lactate and caffeine exercise group experienced a significant increase in the mass of the lower leg muscle groups gastrocnemius (GA) and tibialis anterior (TA) relative to both the sedentary and exercise only groups.*Thelactate and caffeine exercise group*experienced a significant increase in myogenin and follistatin expression of GA relative to the exercise only group.These results suggest that administration of LC can effectively increase muscle mass concomitant with elevated numbers of myonuclei, even with low-intensity exercise training, via activated satellite cells and anabolic signals.**The really exciting aspect of this study seems to suggest that taking caffeine combined with the high intensity exercise which elicits high levels of lactic acid is a good combination for muscle growth and increases in anabolic pathways.

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Disclaimer: Hypermuscles.com does not promote the use of anabolic steroids without a doctor's prescription. The information we share is for entertainment and research purposes only.