Aromasin/Exemestane

Hands down the best down for blasting but it does have its downsides. I found that the more you use aromasin the more senstitive you become to it. When starting out with aromasin even 25mg per day is a common dose for a mild cycle say 750mg test and 500mg deca. As time goes by the more you use it the less aromasin you will need, you will end up needing 12.5mg eod if not less for a mild cycle. It doesn?t happen in a few days though it takes months. Another drawback of aromasin is hairloss, comparing to the other AI?s I found it makes me shed a lot more. Once side effect of aromasin is Alopecia, the other two AI?s have hairloss/hair thinning as a side effect but not full blown Alopecia.

Like mentioned earlier the biggest fear with aromasin is crashing estro to low. At this point all you can do is wait or up your hgh dose. Give it at least 10days before you start taking any more AI even if you are switching to say Adex.

The best write up about aromasin which reflects my experience with it 100% is here:

Ahhhhh-romasin?! The king of anti-estrogens.

This post is kind of long, but take the time to read it, it's probably the most important thing you'll ever read if you're a BB'er (haha well maybe not, but there's some gold in here)

Exemestane, sold under the name Aromasin? by Pfizer, is an orally available suicidal aromatase inhibitor. <This sentence describes exactly why exemestane is the king of Anti-E's for bodybuilding purposes.

Because exemestane is steroidal this gives it a favorable estrogen suppression profile and confers a few really awesome benefits over other anti-estrogens both on paper and in real experience. Steroidal anti-estrogens have the benefit of being lipid-friendly and they all lower SHBG which increases the ratio of free to bound testosterone, which as many experienced BB'ers know can have a relatively profound positive impact on gains.

I think it is important to understand how drugs work in order to properly dose them, exemestane is a suicidal aromatase inhibitor, this means that it binds with aromatase enzymes and as it does so permanently disables the enzyme and destroys it. Hence the "suicidal" this chemical is like a kamikaze pilot out to destroy your aromatase enzymes which is what makes it so special.

Exemestane's half life in the male body is actually very short (~9 hours) and it is quickly eliminated, however, since as soon as it enters your bloodstream it quickly destroys 80-90% of the aromatase enzymes present in your body, it is effective in maintaining significant reductions in estrogen for up to 72 hours after a single 25mg dose. Estrogen levels only begin to rise again after your body has begun to make new aromatase enzymes to replace the ones destro by exemestane.

There is a great study on the pharmacokinetics of exemestane in men which found the following:
-24 hours after one 25mg dose estrogen levels are reduced by 70-80%
-72 hours later estrogen levels are still 40% below baseline even though the drug itself is almost completely eliminated
-120 hours after initial dose estrogen levels return to baseline (without rebounding)

this means that you can find the timing and dosage that works for you, i've seen some guys recommend between 25mg ED and 12.5mg e4d, and you can see why both are effective while providing different levels of estrogen suppression, and it is this flexibility that makes exemestane such a versatile Anti-E.

BUT WAIT, there's more. Aromasin is also a badass PCT drug! In males exemestane was found to increase total testosterone by ~60% after 10 days @ 25mg/day, however the same study found that while it increased total testosterone by 60% free testosterone was increased by over 100 percent! that's right, it DOUBLES bio-available testosterone (natty of course).

I can tell you this much, when I take aromasin for PCT the results are dramatic, honestly my Libido is never absent at any point during PCT and I absolutely feel great within a matter of days, and this is taking 12.5mg ED, the only side effect i notice is stiff joints and other stiff areas

the good:
-powerful aromatase inhibitor capable of stopping gynecomastia completely on its own (for aromatizing compounds)
-has powerful bloat-reduction effects
-lowers SHBG, increasing free test & makes all other anabolic steroids more bio-available (read: more gains)
-can actually boost Libido on and off cycle
-increases IGF-1
-NO adverse changes in lipid profiles for men (granted if you are using it on cycle this may be different)
-is NOT liver toxic
-no estrogen rebound

the bad:
-typical aromatase inhibitor issues here include stiff joints and possibly lethargy
-more difficult to come by than a-dex or letro

Appropriate uses for Exemestane:

#1) on cycle estrogen control - that's right, any and all estrogen related problems can and should be corrected with this compound, from gynecomastia to acne to bloat exemestane is a panacea, run it at 12.5mg e4d for gynecomastia protection and bloat control, or run it at 25mg ED for pre-contest or for gynecomastia sensitive individuals or moon face. the beauty of aromasin is it's okay to use preventatively and not just as spot treatment for gynecomastia as it doesn't hurt gains nearly to the degree that other Anti-E's do, i'd still recommend using Anti-E's only if you need them, but if you must use one throughout your cycle, you couldn't pick a better compound to use.

#2) PCT. Aromasin is the premier PCT drug in my experience... honestly PCT is kind of fun with aromasin (maybe that's a stretch) but it's a breeze compared to clomid/nolva and significantly better than a-dex (more powerful and fewer sides) it works excellently with HCG - human chorionic gonadotropin - and keeps the extra aromatization from the HCG - human chorionic gonadotropin - injects at bay (you can even run higher dosages of HCG - human chorionic gonadotropin - above 500iu/inject) and another bonus is since it's safe and comfortable to run for longer periods of time, you can stretch your PCT out to 6 or 8 weeks for suppressive cycles to make sure you get everything back in full working order

#3) gynecomastia reversal - in conjunction with a selective estrogen receptor modulator (raloxifene or tamoxifen) and/or a dihydrotestosterone derived compound aromasin can be effective in reversing/reducing existing gynecomastia

#4) off cycle testosterone boost - sometimes if i dont feel like running a cycle but still want a little extra kick i'll take 25mg EOD for 4-6 weeks, gains aren't improved all that greatly but significantly, but i do it more for the Libido/mental effects anyways.

#5) hypogonadism - so you're getting older, you've been cycling since you were 21 and your natty test levels just never get back in the good range, but you don't wanna go HRT??? aromasin will get you back in the game without having to take the plunge for HRT.

Inappropriate uses for exemestane:

#1) giving your gf hot flashes

well that's my write up for the best Anti-E out there, i'm sure i left some stuff out, if anyone has any questions feel free to PM me or ask on this thread?

Common dosages: 12.5mg ed/eod, 25mg ed/eod
Trt dosages: 6.25mg ed, 12.5mg 2-3 times per week


<b>Letrozole

This is an AI you can do without its by far the harshest of all AI?s not necessarily cause your estrogen will be too low, letrozole as a compound/active ingredient is really harsh

Ever climb up the stairs and felt as if you were dying same as a 500lb man would after taking two steps? That?s what letro can do to you. My view on this is that it affects ones triglycerides, if you use letro long enough at max dose your triglycerides will be so high that even after climbing ten steps you will be struggling to breath

Only application of letro (which can be avoided/substituted with aromasin) is for contest prep, I would never use it for either bulk, cut or gyno reversal too many side effects for very little gain

Also ever took letro and still had nipple sentivity? Wonder why? Letro lowers shgb dramatically this allows free testosterone to spike and as a result free estrogen, this is the reason the letro gyno reversal protocol doesn?t work (esp when its suggested to use it for one week only). In order to have low free estrogen (Which AI?s cant lower) you need to drop your total estrogen low. However everyone trying to reverse gyno already have high estrogen and the moment you add letro you have a tonne of free estrogen in your blood stream, which can make your gyno worse.. To protect against free estrogen you need a serm, that?s why you cant have gyno reversal without a serm since all AI?s lower shgb.
Keep in mind you cant use nolva with adex or letro you minimize their efficiency by 40% that doesn?t work vice versa though nolvadex efficiency stays at 100%.

Common dosage: 0.62mg ed/eod, 1.25mg ed/eod