yes a big difference my friend .. depending on the move & manuver..

palms facing down is called ------- PRONATED
palms facing up is called ---------- SUPINATED
palms facing to ur side is ----------- NEUTRAL

for this move it creates a greater contracting therefore leading to greater muscle fiber recruitment.. i would suggest tht you alternate through the move with a neutral to a pronated grip.. and try sitting down when exicuiting this manuver as well.. ull have more focus with the move as to where standing ..

the shoulder is a phasic muscle .. meaning tht its not easily facilitated .. its either on or off .. un like tonic muscles
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